Format

Send to

Choose Destination
Cell. 2018 Sep 20;175(1):277-291.e31. doi: 10.1016/j.cell.2018.08.060.

Dynamic Human Environmental Exposome Revealed by Longitudinal Personal Monitoring.

Author information

1
Department of Genetics, Stanford University School of Medicine, Stanford, CA 94304, USA. Electronic address: jiangch@stanford.edu.
2
Department of Genetics, Stanford University School of Medicine, Stanford, CA 94304, USA. Electronic address: xw87@stanford.edu.
3
Department of Genetics, Stanford University School of Medicine, Stanford, CA 94304, USA.
4
Department of Genetics, Stanford University School of Medicine, Stanford, CA 94304, USA. Electronic address: mpsnyder@stanford.edu.

Abstract

Human health is dependent upon environmental exposures, yet the diversity and variation in exposures are poorly understood. We developed a sensitive method to monitor personal airborne biological and chemical exposures and followed the personal exposomes of 15 individuals for up to 890 days and over 66 distinct geographical locations. We found that individuals are potentially exposed to thousands of pan-domain species and chemical compounds, including insecticides and carcinogens. Personal biological and chemical exposomes are highly dynamic and vary spatiotemporally, even for individuals located in the same general geographical region. Integrated analysis of biological and chemical exposomes revealed strong location-dependent relationships. Finally, construction of an exposome interaction network demonstrated the presence of distinct yet interconnected human- and environment-centric clouds, comprised of interacting ecosystems such as human, flora, pets, and arthropods. Overall, we demonstrate that human exposomes are diverse, dynamic, spatiotemporally-driven interaction networks with the potential to impact human health.

PMID:
30241608
DOI:
10.1016/j.cell.2018.08.060

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center