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Biomaterials. 2018 Aug;175:72-81. doi: 10.1016/j.biomaterials.2018.05.016. Epub 2018 May 17.

Ingestible roasted barley for contrast-enhanced photoacoustic imaging in animal and human subjects.

Author information

1
Department of Biomedical Engineering, University at Buffalo, State University of New York, Buffalo, USA.
2
Department of Electrical Engineering, University at Buffalo, State University of New York, Buffalo, USA.
3
Department of Linguistics and Speech and Hearing Science, University at Buffalo, State University of New York, Buffalo, USA.
4
Department of Biomedical Engineering, University at Buffalo, State University of New York, Buffalo, USA. Electronic address: junxia@buffalo.edu.

Abstract

Photoacoustic computed tomography (PACT) is an emerging imaging modality. While many contrast agents have been developed for PACT, these typically cannot immediately be used in humans due to the lengthy regulatory process. We screened two hundred types of ingestible foodstuff samples for photoacoustic contrast with 1064 nm pulse laser excitation, and identified roasted barley as a promising candidate. Twenty brands of roasted barley were further screened to identify the one with the strongest contrast, presumably based on complex chemical modifications incurred during the roasting process. Individual roasted barley particles could be detected through 3.5 cm of chicken-breast tissue and through the whole hand of healthy human volunteers. With PACT, but not ultrasound imaging, a single grain of roasted barley was detected in a field of hundreds of non-roasted particles. Upon oral administration, roasted barley enabled imaging of the gut and peristalsis in mice. Prepared roasted barley tea could be detected through 2.5 cm chicken breast tissue. When barley tea was administered to humans, photoacoustic imaging visualized swallowing dynamics in healthy volunteers. Thus, roasted barley represents an edible foodstuff that should be considered for photoacoustic contrast imaging of swallowing and gut processes, with immediate potential for clinical translation.

KEYWORDS:

Contrast agent; Ingestible; Photoacoustic tomography; Roasted barley; Swallowing

PMID:
29803105
PMCID:
PMC6010199
[Available on 2019-08-01]
DOI:
10.1016/j.biomaterials.2018.05.016

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