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Trends Parasitol. 2019 Sep;35(9):715-724. doi: 10.1016/j.pt.2019.06.012. Epub 2019 Jul 15.

Noncoding RNAs in Parasite-Vector-Host Interactions.

Author information

1
Biology Center of the Czech Academy of Sciences, Branisovska 31, 37005 Budweis, (Ceske Budejovice), Czechia.
2
Dpto. de Genética, Facultad de Ciencias, Universidad de Granada, Campus de Fuentenueva s/n, 18071, Granada, Spain; Lab. de Bioinformática, Centro de Investigación Biomédica (CIBM), PTS, Avda. del Conocimiento s/n, 18100, Granada, Spain.
3
Biology Center of the Czech Academy of Sciences, Branisovska 31, 37005 Budweis, (Ceske Budejovice), Czechia. Electronic address: kotsyfakis@paru.cas.cz.

Abstract

Systems biology approaches, especially in the big data era, have revolutionized modern parasitology. Of the many different molecules participating in parasite-host interactions, noncoding RNAs (ncRNAs) are now known to be (i) transmitted by the vector to possibly modulate vertebrate host responses and favor vector survival and (ii) regulated in the host by parasites to favor parasite survival. Here we provide an overview of the involvement of ncRNAs in the parasite-vector-host triad and their effect on host homeostasis based on recent advances and accumulating knowledge about the role of endogenous vertebrate noncoding RNAs in vertebrate host physiology.

KEYWORDS:

arthropod vectors; epigenetics; miRNA; noncoding RNA; parasite–vertebrate–host interaction; pathogenesis

PMID:
31320293
DOI:
10.1016/j.pt.2019.06.012

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