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Oral Surg Oral Med Oral Pathol Oral Radiol. 2018 May;125(5):454-458. doi: 10.1016/j.oooo.2018.02.014. Epub 2018 Mar 6.

EGFR is not amplified in ameloblastoma.

Author information

1
Department of Biosciences and Oral Diagnosis, Institute of Science and Technology, São Paulo State University (Unesp), São José dos Campos, Brazil.
2
Department of Oral Medicine, Sírio-Libanês Hospital, São Paulo, Brazil.
3
Department of Oral Surgery and Pathology, School of Dentistry, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil.
4
Department of Stomatology, A.C. Camargo Cancer Center, São Paulo, Brazil.
5
Department of Anatomic Pathology, A.C. Camargo Cancer Center, São Paulo, Brazil.
6
Department of Biosciences and Oral Diagnosis, Institute of Science and Technology, São Paulo State University (Unesp), São José dos Campos, Brazil. Electronic address: estela@ict.unesp.br.

Abstract

OBJECTIVE:

The aim of this study was to investigate alterations in the EGFR gene and its protein expression for a better understanding of the biologic behavior of ameloblastoma.

STUDY DESIGN:

Twenty-five samples of ameloblastoma were selected, and dual-color fluorescence in situ hybridization assay was performed. The results of the assay and immunohistochemistry reaction for EGFR and Ki67 were associated with clinicopathologic features and recurrence.

RESULTS:

All analyzed cases presented disomy without any gene polysomy or amplification. With regard to EGFR immunoexpression, 3 cases (12%) were considered negative, and 22 (88%) were positive, of which 13 (52%) were weak and 9 (36%) were strong. All samples presented low positivity for Ki67. There was no association between EGFR expression and clinicopathologic features or recurrence (P > .05). In some cases, EGFR immunoexpression was observed without gene amplification.

CONCLUSIONS:

Ameloblastoma development, progression, or recurrence does not appear to be related to EGFR amplification or polysomy.

PMID:
29602688
DOI:
10.1016/j.oooo.2018.02.014
[Indexed for MEDLINE]

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