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Oral Surg Oral Med Oral Pathol Oral Radiol. 2018 Apr;125(4):317-325. doi: 10.1016/j.oooo.2018.01.003. Epub 2018 Feb 2.

Expression of cell cycle proteins according to HPV status in oral squamous cell carcinoma affecting young patients: a pilot study.

Author information

1
Department of Oral Diagnosis, Piracicaba Dental School, University of Campinas, Piracicaba, Brazil.
2
Departament of Bioscience and Oral Diagnosis, Science and Technology Institute, Universidade Estadual Paulista, São José dos Campos, Brazil.
3
Department of Oral Surgery and Pathology, School of Dentistry, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil.
4
Department of Anatomic Pathology, AC Camargo Cancer Center, São Paulo, Brazil.
5
Department of Head and Neck Surgery and Otorhinolaryngology, AC Camargo Cancer Center, São Paulo, Brazil. Electronic address: lp_kowalski@uol.com.br.

Abstract

OBJECTIVE:

Tobacco and alcohol consumption are considered the main risk factors for oral squamous cell carcinoma (OSCC); however, the role of these factors in patients younger than 40 years is controversial, so it has been suggested that genomic instability and high-risk human papillomavirus (HR-HPV) infection may be contributing factors to oral carcinogenesis at a young age. Therefore, the aim of this study was to evaluate the immunoexpression of cell cycle proteins according HPV status in OSCC affecting young patients.

METHODS:

A tissue microarray construction based on 34 OSCC samples from young patients (<40 years old) was subjected to immunohistochemical reactions for Ki67, cyclin D1, C-ErbB2, p21, Myc, epidermal growth factor receptor, p53, and p16 antibodies.

RESULTS:

The clinicopathologic features and the immunoexpression of all tested proteins were similar in both groups. Patients with HPV-related OSSC tended to have better cancer-specific survival (CSS; 39% vs 60% 5-y CSS), and overall survival (OS; 29.2% vs 60% 5-year OS). However, this difference was not statistically significant.

CONCLUSION:

No significant difference exists in the expression of cell cycle proteins studied between HR-HPV DNA-positive and HR-HPV DNA-negative OSCC affecting young patients.

PMID:
29501355
DOI:
10.1016/j.oooo.2018.01.003
[Indexed for MEDLINE]
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