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Int J Infect Dis. 2018 Dec;77:26-28. doi: 10.1016/j.ijid.2018.07.021. Epub 2018 Jul 29.

Respiratory microsporidiosis caused by Enterocytozoon bieneusi in an HIV-negative hematopoietic stem cell transplant recipient.

Author information

1
Department of Biology and Medical Parasitology, Wroclaw Medical University, Wroclaw, Poland. Electronic address: marta.kicia@umed.wroc.pl.
2
Lower Silesian Center for Cellular Transplantations, Wroclaw, Poland.
3
Biology Centre of the Czech Academy of Sciences, Institute of Parasitology, České Budějovice, Czech Republic.
4
Biology Centre of the Czech Academy of Sciences, Institute of Parasitology, České Budějovice, Czech Republic; University of South Bohemia, Faculty of Agriculture, České Budějovice, Czech Republic.
5
Department of Biology and Medical Parasitology, Wroclaw Medical University, Wroclaw, Poland.

Abstract

A 23-year-old, HIV-negative woman who had undergone a hematopoietic stem cell transplantation was admitted to the hospital with respiratory failure and symptoms of bronchiolitis obliterans. A chest computed tomography scan revealed diffuse ground-glass opacification and fibrous plugs. Due to worsening respiratory failure despite treatment, ventilation was provided through a tracheostomy tube. Molecular examination of bronchoalveolar lavage and urine revealed Enterocytozoon bieneusi infection. After treatment with albendazole the patient gradually improved, but the pathogen was not eradicated and reappeared on follow-up examination. E. bieneusi belongs to the most clinically important microsporidial species infecting humans, mostly those who are immunocompromised. This fungus tends to infect enterocytes of the intestine, and there are limited studies concerning its extraintestinal location. This is the first report of a case of disseminated respiratory and urinary E. bieneusi infection in a transplant recipient.

KEYWORDS:

Enterocytozoon bieneusi; Hematopoietic stem cell transplant; Respiratory tract infection

PMID:
30063985
DOI:
10.1016/j.ijid.2018.07.021
[Indexed for MEDLINE]
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