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Arch Oral Biol. 2018 Mar;87:151-156. doi: 10.1016/j.archoralbio.2017.12.017. Epub 2017 Dec 21.

Immunoexpression of proteins involved in cytoskeleton remodeling in benign odontogenic lesions.

Author information

1
Department of Stomatology, Area of Pathology, Bauru School of Dentistry, University of São Paulo, Al. Dr. Octávio Pinheiro Brisolla, 9-75, Bauru, SP, 17120-901, Brazil. Electronic address: paula.pna@hotmail.com.
2
Department of Stomatology, Area of Pathology, Bauru School of Dentistry, University of São Paulo, Al. Dr. Octávio Pinheiro Brisolla, 9-75, Bauru, SP, 17120-901, Brazil. Electronic address: natggalvao@hotmail.com.
3
Department of Stomatology, Area of Pathology, Bauru School of Dentistry, University of São Paulo, Al. Dr. Octávio Pinheiro Brisolla, 9-75, Bauru, SP, 17120-901, Brazil. Electronic address: agnesassao@gmail.com.
4
Department of Community Dentistry, Bauru School of Dentistry, University of São Paulo, Al. Dr. Octávio Pinheiro Brisolla, 9-75, Bauru, SP, 17120-901, Brazil. Electronic address: jrlauris@fob.usp.br.
5
Department of Pathology, A.C. Camargo Cancer Hospital, R. Prof. Antônio Prudente, 211, São Paulo, SP, 01509-010, Brazil. Electronic address: fasoares@mac.com.
6
Department of Stomatology, Area of Pathology, Bauru School of Dentistry, University of São Paulo, Al. Dr. Octávio Pinheiro Brisolla, 9-75, Bauru, SP, 17120-901, Brazil. Electronic address: denisetostes@usp.br.

Abstract

OBJECTIVE:

The present study was designed to analyze the immunolocalization of proteins involved in cytoskeleton remodeling, such as moesin and Rho-A, in benign odontogenic lesions that present with expansive growth and invasive clinical behavior.

MATERIALS AND METHODS:

Expressions of moesin and Rho-A in odontogenic epithelium were evaluated by immunohistochemical analysis in 45 odontogenic lesions using monoclonal antibodies.

RESULTS:

Our results demonstrated strong membranous and cytoplasmic expressions of moesin in the epithelial cells in 66.7% and 44.4% of the odontogenic lesions, respectively. Furthermore, Rho-A expression in odontogenic epithelium was strong in the membrane and cytoplasm of 51.1% and 62.2% of the odontogenic lesions, respectively. A statistically significant correlation was found between the membranous and cytoplasmic expressions of moesin (p = 0.000) and those of Rho-A (p = 0.048) in odontogenic epithelial cells, while no statistically significant correlation was found between moesin and Rho-A expressions (p > 0.05).

CONCLUSIONS:

The present study confirmed the strong expressions of moesin and Rho-A by odontogenic epithelial cells, suggesting their involvement in the development of benign odontogenic lesions. However, this study has failed to detect the connection between the moesin and Rho-A interaction in expansive growth and local invasiveness of these lesions.

KEYWORDS:

ERM proteins; Moesin; Odontogenic lesions; Rho-A

[Indexed for MEDLINE]

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