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Am J Clin Dermatol. 2018 Nov;19(Suppl 1):3-14. doi: 10.1007/s40257-018-0367-4.

Noninvasive Imaging Tools in the Diagnosis and Treatment of Skin Cancers.

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Hospital de Clínicas de Porto Alegre, Universidade Federal do Rio Grande do Sul, Rua Ramiro BArcellos 2350, Porto Alegre, RS, 90035-007, Brazil.
Skin Cancer Department, AC Camargo Cancer Center, Rua Prof. Antônio Prudente, 211-Liberdade, São Paulo, SP, 01509-010, Brazil.
Dermato-Oncology Clinic, Faculty of Medicine, Universidad Nacional Autónoma de México, Circuito Escolar s/n (Edificio Consejo Técnico Facultad de Medicina), Avenida Universidad 3000, Coyoacan, 04510, Mexico City, Mexico.
Hospital Provincial del Centenario de Rosario, Argentina, Diagnóstico Médico Oroño, Bv. Oroño 1515, 2000, Rosario, Argentina.


In the 1980s, the increasing incidence of skin cancers prompted the development of noninvasive medical devices to improve skin cancer diagnosis in daily dermatology practice. As a result of the development of these noninvasive techniques, diagnosis is now established earlier and with better accuracy. These advances are of great benefit to high-risk patients, who previously would have had to undergo several excisions. In this review, we focus on the classic technique of dermoscopy and the more recent digital version, as well as on advanced noninvasive imaging techniques, such as reflectance confocal microscopy and optical coherence tomography. On the basis of their specific features, these noninvasive medical devices can be used not only to diagnose and monitor melanoma and nonmelanoma skin cancers but also to choose the best therapy and follow the patient's response to treatment in vivo.

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