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Clin Pharmacol Ther. 2019 Feb 10. doi: 10.1002/cpt.1390. [Epub ahead of print]

Impact of Oncology Drug Shortages on Chemotherapy Treatment.

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University of Pennsylvania and National Bureau of Economic Research, Philadelphia, Pennsylvania, USA.
University of Southern California and National Bureau of Economic Research, Los Angeles, California, USA.


Prescription drug shortages began to increase markedly in the mid-2000s, including sterile injectable products such as chemotherapy drugs. Using Medicare claims linked to Surveillance Epidemiology and End Results (SEER), we examined outpatient chemotherapy use during shortage periods relative to the months before and after a shortage for newly diagnosed patients with breast, colorectal, leukemia, lung, lymphoma, ovarian, or pancreatic cancer (N = 182,470). For most drugs, we found little impact of shortages on either the fraction of patients receiving that drug or the quantity provided. In some cases, we found declines in utilization: 4% for doxorubicin and fluorouracil; 2.9% for oxaliplatin; and about 1% for cytarabine, dacarbazine, and leuprolide. Although shortages for a few drugs resulted in substantial reductions in use, in most cases, they resulted in little to no reduction. We discuss potential explanations for these counterintuitive findings, including potential limitations of current drug shortage reporting methods.


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