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J Comp Neurol. 2019 Feb 15;527(3):522-534. doi: 10.1002/cne.24417. Epub 2018 Mar 9.

Binocular response modulation in the lateral geniculate nucleus.

Author information

1
Department of Psychology, Center for Cognitive and Integrative Neuroscience, Vanderbilt Vision Research Center, Vanderbilt University, Nashville, Tennessee 37203.
2
Institute of Neuroscience, Newcastle University, Newcastle upon Tyne, NE2 4HH, UK.

Abstract

The dorsal lateral geniculate nucleus of the thalamus (LGN) receives the main outputs of both eyes and relays those signals to the visual cortex. Each retina projects to separate layers of the LGN so that each LGN neuron is innervated by a single eye. In line with this anatomical separation, visual responses of almost all of LGN neurons are driven by one eye only. Nonetheless, many LGN neurons are sensitive to what is shown to the other eye as their visual responses differ when both eyes are stimulated compared to when the driving eye is stimulated in isolation. This, predominantly suppressive, binocular modulation of LGN responses might suggest that the LGN is the first location in the primary visual pathway where the outputs from the two eyes interact. Indeed, the LGN features several anatomical structures that would allow for LGN neurons responding to one eye to modulate neurons that respond to the other eye. However, it is also possible that binocular response modulation in the LGN arises indirectly as the LGN also receives input from binocular visual structures. Here we review the extant literature on the effects of binocular stimulation on LGN spiking responses, highlighting findings from cats and primates, and evaluate the neural circuits that might mediate binocular response modulation in the LGN.

KEYWORDS:

binocular combination; binocular integration; binocular vision; lateral geniculate nucleus; neurophysiology

PMID:
29473163
PMCID:
PMC6107447
[Available on 2020-02-15]
DOI:
10.1002/cne.24417

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