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Angew Chem Int Ed Engl. 2018 Mar 5;57(11):2938-2942. doi: 10.1002/anie.201712811. Epub 2018 Feb 9.

Synergistic N-Heterocyclic Carbene/Palladium-Catalyzed Reactions of Aldehyde Acyl Anions with either Diarylmethyl or Allylic Carbonates.

Author information

1
Division of Pharmaceutical Sciences, Graduate School of Medical Sciences, Kanazawa University, Kakuma-machi, Kanazawa, 920-1192, Japan.

Abstract

Benzylation and allylation of aldehyde acyl anions were enabled by the merger of a thiazolium N-heterocyclic carbene (NHC) catalyst and a palladium/bisphosphine catalyst in a synergistic manner. Owing to the mildness of the reaction conditions, various functional groups were tolerated in the substrates.

KEYWORDS:

aldehydes; carbenes; ketones; palladium; synthetic methods

PMID:
29359835
DOI:
10.1002/anie.201712811

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