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J Surg Oncol. 2018 Apr;117(5):845-850. doi: 10.1002/jso.25039. Epub 2018 Mar 6.

Relapse in dermatofibrosarcoma protuberans: A histological and molecular analysis.

Author information

1
Skin Cancer Department, AC Camargo Cancer Hospital, São Paulo, Brazil.
2
Department of Pathology, AC Camargo Cancer Hospital, São Paulo, Brazil.
3
Research and Teaching Institute of Barretos Cancer Hospital, Barretos, Brazil.
4
Resident of Surgical Oncology, AC Camargo Cancer Hospital, São Paulo, Brazil.

Abstract

BACKGROUND:

Dermatofibrosarcoma protuberans (DFSP) is a rare low grade tumor with a locally aggressive behavior and low metastatic potential.

OBJECTIVES:

To evaluate the factors that are associated with relapse in DFSP. Methods Retrospective analysis of medical records from 61 patients with dermatofibrosarcoma. Fluorescence in situ hybridization was used to detect translocations.

RESULTS:

Of 61 patients, 6 experienced a relapse. No patient with resection margins greater than 3 cm had a recurrence. One relapse was observed in a patient treated with at least 2 cm margins and 4 relapses occurred in 16 patients whose margins were below 2 cm (P = 0.018). The frequency of translocations was 77.8%. The recurrence rate was lower in patients with translocation, but this difference was not significant. Immunohistochemical markers did not correlate with recurrence rates, but greater FasL expression was associated with recurrence in patients with margins smaller than 3 cm.

CONCLUSIONS:

Surgical margins smaller than than 2 cm are related to higher recurrences in dermatofibrosarcomas. In this analysis a 2 cm margin was acceptable for treatment. Between all the immunohistochemical markers analyzed, only FasL was associated with a higher recurrence rate in patients with margins smaller than 3 cm.

KEYWORDS:

dermatofibrosarcoma protuberans; molecular and histological analysis; relapse

PMID:
29509956
DOI:
10.1002/jso.25039
[Indexed for MEDLINE]

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