Format

Send to

Choose Destination
  • Query can only process the first 100 words.
  • The following term was not found in PubMed: pp497-510.
Aging Cell. 2015 Aug;14(4):497-510. doi: 10.1111/acel.12338. Epub 2015 Apr 22.

Interventions to Slow Aging in Humans: Are We Ready?

Author information

1
Davis School of Gerontology and Department of Biological Sciences, Longevity Institute, University of Southern California, Los Angeles, CA, 90089, USA.
2
IFOM, FIRC Institute of Molecular Oncology, Via Adamello 16, 20139, Milano, Italy.
3
Max Planck Institute for Biology of Ageing, Joseph Stelzmann Strasse 9b, 50931, Koeln, Germany.
4
Department of Internal Medicine, Southern Illinois University-School of Medicine, Springfield, IL, 62794, USA.
5
Institute for Aging Research, Albert Einstein College of Medicine, 1300 Morris Park Ave, Bronx, NY, 10461, USA.
6
Department of Basic Sciences, University of North Dakota School of Medicine and Health Sciences, Grand Forks, ND, 58203, USA.
7
Immunosenescence Unit, Department of Pathobiology and Medical and Forensic Biotechnologies, University of Palermo, Palermo, Italy.
8
Department of Medicine, University of Texas Health Science Center, San Antonio, TX, USA.
9
Experimental Gerontology Section, TGB, NIA, NIH, 251 Bayview Blvd. Suite 100/Room 9C218, Baltimore, MD, 21224, USA.
10
DIMES-Department of Specialty, Diagnostic and Experimental Medicine, Via S. Giacomo, 12, I-40126, Bologna, Italy.
11
Department of Genetics, Evolution and Environment, Institute of Healthy Ageing, University College London, The Darwin Building, Gower Street, London, WC1E 6BT, UK.
12
Nutritional Neuroscience and Aging Laboratory, Pennington Biomedical Research Center, Louisiana State University System, 6400 Perkins Road, Baton Rouge, LA, 70809, USA.
13
Institute for Behavioral Genetics, University of Colorado at Boulder, Box 447, Boulder, CO, 80309, USA.
14
Buck Institute for Research on Aging, Novato, CA, USA.
15
Department of Biochemistry and Biophysics, Mission Bay Genentech Hall, University of California, 600 16th Street, Room S312D, San Francisco, CA, 94158-2517, USA.
16
Center for Human Nutrition, Washington University School of Medicine, Campus Box 8031, 660 South Euclid Avenue, St. Louis, MO, 63110, USA.
17
Department of Biomedical Sciences, Edison Biotechnology Institute, Heritage College of Osteopathic Medicine, Ohio University, Athens, OH, 45701, USA.
18
Institut für Alternsforschung, Universität Innsbruck, Rennweg 10, A-6020, Innsbruck, Austria.
19
Institute of Molecular Biosciences, NAWI Graz, University of Graz, Humboldtstr. 50, Graz, 8010, Austria.
20
BioTechMed Graz, Humboldtstr. 50, Graz, 8010, Austria.
21
Dipartimento di Biopatologia e Biotecnologie mediche, Universita' di Palermo, Via Divisi 83, 90133, Palermo, Italy.
22
Department of Genetics and Complex Diseases, Harvard School of Public Health, Boston, MA, 02115, USA.
23
Department of Biology, Ecology and Earth Science, University of Calabria, 87036, Rende, Italy.
24
Leibniz Institute for Age Research, Fritz Lipmann Institute, D-07745, Jena, Germany.
25
Laboratories for Molecular Medicine, Department of Molecular Biology, Cell Biology and Biochemistry, Brown University, 70 Ship Street, Providence, RI, 02903, USA.
26
Department of Pathology, Yale University School of Medicine, New Haven, CT, 06520, USA.
27
Department of Genetics, Yale University School of Medicine, New Haven, CT, 06520, USA.
28
Laboratory for Ageing Research, Department of Pharmacology, School of Medical Sciences, UNSW Australia, Sydney, NSW, Australia.
29
Australia Glenn Labs for the Biological Mechanisms of Aging, Department of Genetics, Harvard Medical School, Boston, MA, Australia.
30
Department of Biochemistry, University of California at Riverside, Riverside, CA, USA.
31
Department of Genetics, Albert Einstein College of Medicine, Bronx, NY, USA.
32
Department of Medicine, Diabetes Research and Training Center, Albert Einstein College of Medicine, Bronx, NY, USA.
33
Institute for Aging Research, Diabetes Research and Training Center, Albert Einstein College of Medicine, Bronx, NY, USA.
34
Department of Genetics, Albert Einstein Medical Center, 1301 Morris Park Avenue, Bronx, NY, USA.
35
Division of Medicine, University College London (UCL) - Institute for Liver and Digestive Health, Royal Free Hospital, London, UK.
36
Department of Medicine, Washington University School of Medicine, St. Louis, MO, USA.
37
Department of Clinical and Experimental Sciences, Brescia University, Brescia, Italy.
38
CEINGE Biotecnologie Avanzate, Napoli, Italy.

Abstract

The workshop entitled 'Interventions to Slow Aging in Humans: Are We Ready?' was held in Erice, Italy, on October 8-13, 2013, to bring together leading experts in the biology and genetics of aging and obtain a consensus related to the discovery and development of safe interventions to slow aging and increase healthy lifespan in humans. There was consensus that there is sufficient evidence that aging interventions will delay and prevent disease onset for many chronic conditions of adult and old age. Essential pathways have been identified, and behavioral, dietary, and pharmacologic approaches have emerged. Although many gene targets and drugs were discussed and there was not complete consensus about all interventions, the participants selected a subset of the most promising strategies that could be tested in humans for their effects on healthspan. These were: (i) dietary interventions mimicking chronic dietary restriction (periodic fasting mimicking diets, protein restriction, etc.); (ii) drugs that inhibit the growth hormone/IGF-I axis; (iii) drugs that inhibit the mTOR-S6K pathway; or (iv) drugs that activate AMPK or specific sirtuins. These choices were based in part on consistent evidence for the pro-longevity effects and ability of these interventions to prevent or delay multiple age-related diseases and improve healthspan in simple model organisms and rodents and their potential to be safe and effective in extending human healthspan. The authors of this manuscript were speakers and discussants invited to the workshop. The following summary highlights the major points addressed and the conclusions of the meeting.

KEYWORDS:

aging; anti-aging; centenarians; dietary restriction; lifespan studies; longevity gene; longevity regulation

PMID:
25902704
PMCID:
PMC4531065
DOI:
10.1111/acel.12338
[Indexed for MEDLINE]
Free PMC Article

Publication types, MeSH terms, Substances, Grant support

Supplemental Content

Full text links

Icon for Wiley Icon for PubMed Central
Loading ...
Support Center