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131 results

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1,3-Dichloro-2-propanol induced ferroptosis through Nrf2/ARE signaling pathway in hepatocytes.
Guan S, Zhang R, Zhao Y, Meng Z, Lu J. Guan S, et al. Environ Toxicol. 2022 Oct;37(10):2515-2528. doi: 10.1002/tox.23615. Epub 2022 Jul 23. Environ Toxicol. 2022. PMID: 35870111
1,3-Dichloro-2-propanol (1,3-DCP) is a representative chloropropane environmental contaminant with multiple toxicities. ...
1,3-Dichloro-2-propanol (1,3-DCP) is a representative chloropropane environmental contaminant with multip …
1,3-Dichloro-2-propanol-Induced Renal Tubular Cell Necroptosis through the ROS/RIPK3/MLKL Pathway.
Fan Y, Lu J, Yu Z, Qu X, Guan S. Fan Y, et al. J Agric Food Chem. 2022 Sep 7;70(35):10847-10857. doi: 10.1021/acs.jafc.2c02619. Epub 2022 Aug 24. J Agric Food Chem. 2022. PMID: 36000575
1,3-Dichloro-2-propanol (1,3-DCP), as a food pollutant, exists in a variety of foods. ...
1,3-Dichloro-2-propanol (1,3-DCP), as a food pollutant, exists in a variety of foods. ...
Diallyl disulfide prevents 1,3-dichloro-2-propanol-induced hepatotoxicity through mitogen-activated protein kinases signaling.
Kim JW, Kim JH, Kim CY, Jeong JS, Lim JO, Kim JC, Ko JW, Kim TW. Kim JW, et al. Food Chem Toxicol. 2022 Feb;160:112814. doi: 10.1016/j.fct.2022.112814. Epub 2022 Jan 6. Food Chem Toxicol. 2022. PMID: 34999178
We investigated whether diallyl disulfide (DADS) has protective effects against 1,3-dichloro-2-propanol (1,3-DCP)-induced hepatotoxicity and oxidative damage in rats and HepG2 cells. ...
We investigated whether diallyl disulfide (DADS) has protective effects against 1,3-dichloro-2-propanol ( …
1,3-dichloro-2-propanol induced lipid accumulation by blocking autophagy flux in HepG2 cells.
Lu J, Fan Y, Liu M, Zhang Q, Guan S. Lu J, et al. Toxicology. 2021 Apr 30;454:152716. doi: 10.1016/j.tox.2021.152716. Epub 2021 Feb 10. Toxicology. 2021. PMID: 33581215
Great attention has been paid to 1,3-dichloro-2-propanol (1,3-DCP) due to its presence in food and concerns about toxic potential as carcinogens. ...
Great attention has been paid to 1,3-dichloro-2-propanol (1,3-DCP) due to its presence in food and concer …
1,3-dichloro-2-propanol caused lipid droplets accumulation by suppressing neutral lipases via BMAL1 in hepatocytes.
Fan Y, Lu J, Fan J, Guan S. Fan Y, et al. Food Chem Toxicol. 2023 Apr;174:113670. doi: 10.1016/j.fct.2023.113670. Epub 2023 Feb 18. Food Chem Toxicol. 2023. PMID: 36805544
Circadian rhythm regulates body physiology and metabolism to adapt to the external environment. 1,3-dichloro-2-propanol (1,3-DCP) is a food pollutant formed during food processing. ...
Circadian rhythm regulates body physiology and metabolism to adapt to the external environment. 1,3-dichloro-2- …
1,3-dichloro-2-propanol induced hepatic lipid accumulation by inhibiting autophagy via AKT/mTOR/FOXO1 pathway in mice.
Fan Y, Lu J, Liu J, Zhang R, Yu Z, Guan S. Fan Y, et al. Food Chem Toxicol. 2021 Nov;157:112578. doi: 10.1016/j.fct.2021.112578. Epub 2021 Sep 21. Food Chem Toxicol. 2021. PMID: 34560177
Our study investigated the effects of food contaminant 1,3-dichloro-2-propanol (1,3-DCP) on hepatic lipid metabolism and its mechanism. ...
Our study investigated the effects of food contaminant 1,3-dichloro-2-propanol (1,3-DCP) on hepatic lipid …
Toxicology, occurrence and risk characterisation of the chloropropanols in food: 2-monochloro-1,3-propanediol, 1,3-dichloro-2-propanol and 2,3-dichloro-1-propanol.
Andres S, Appel KE, Lampen A. Andres S, et al. Food Chem Toxicol. 2013 Aug;58:467-78. doi: 10.1016/j.fct.2013.05.024. Epub 2013 May 24. Food Chem Toxicol. 2013. PMID: 23712097 Review.
The dietary exposure to 1,3-dichloro-2-propanol is quite low. Calculated "Margins of Exposure" values are above 10,000. It is concluded that the 1,3-dichloro-2-propanol exposure is of low concern for human heal …
The dietary exposure to 1,3-dichloro-2-propanol is quite low. Calculated "Margins of Exposure" values are …
1,3-Dichloro-2-Propanol inhibits autophagy via P53/AMPK/mTOR pathway in HepG2 cells.
Cheng B, Lu J, Li T, Meng Z, Liu M, Sun M, Guan S. Cheng B, et al. Food Chem Toxicol. 2018 Dec;122:143-150. doi: 10.1016/j.fct.2018.10.030. Epub 2018 Oct 11. Food Chem Toxicol. 2018. PMID: 30316840
As a common food processing pollutant, 1,3-Dichloro-2-propanol can be found in foodstuffs, especially in soup spices and instant soups. ...
As a common food processing pollutant, 1,3-Dichloro-2-propanol can be found in foodstuffs, especially in …
Alliin attenuates 1, 3-dichloro-2-propanol-induced lipogenesis in HepG2 cells through activation of the AMP-activated protein kinase-dependent pathway.
Lu J, Cheng B, Meng Z, Fang B, Li T, Sun M, Liu M, Guan S. Lu J, et al. Life Sci. 2018 Feb 15;195:19-24. doi: 10.1016/j.lfs.2017.12.040. Epub 2018 Jan 2. Life Sci. 2018. PMID: 29305303
Accumulating evidence reveals the association of 1, 3-dichloro-2-propanol (1, 3-DCP) exposure and lipogenesis. Alliin, the most abundant sulphur compound in garlic, has been demonstrated to exhibit hypoglycemic, antioxidant and anti-inflammatory …
Accumulating evidence reveals the association of 1, 3-dichloro-2-propanol (1, 3-DCP) exposure and lipogen …
1,3-Dichloro-2-propanol evokes inflammation and apoptosis in BV-2 microglia via MAPKs and NF-kappaB signaling pathways mediated by reactive oxygen species.
Xiao C, He P, Han J, Tang M, Wang Z, Mi Y, Liu X. Xiao C, et al. Toxicol Lett. 2018 Mar 1;284:103-112. doi: 10.1016/j.toxlet.2017.12.011. Epub 2017 Dec 14. Toxicol Lett. 2018. PMID: 29248572
1,3-dichloro-2-propanol (1,3-DCP) is a widely concerned food processing contaminant which has been investigated for decades. ...
1,3-dichloro-2-propanol (1,3-DCP) is a widely concerned food processing contaminant which has been invest …
131 results