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Cell Res. 2015 Dec;25(12):1283-4. doi: 10.1038/cr.2015.135. Epub 2015 Nov 24.

RNA editing by ADAR1 marks dsRNA as "self".

Yu Z1, Chen T2, Cao X1,2.

Author information

1
National Key Laboratory of Medical Molecular Biology & Department of Immunology, Institute of Basic Medical Sciences, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing 100005, China.
2
National Key Laboratory of Medical Immunology & Institute of Immunology, Second Military Medical University, Shanghai 200433, China.

Abstract

A paper recently published in Science reports that adenosine deaminase acting on RNA 1-dependent adenosine-to-inosine editing marks endogenous double strand RNA as self and prevents their immune recognition by cytosolic RNA sensor MDA5.

PMID:
26596786
PMCID:
PMC4670992
DOI:
10.1038/cr.2015.135
[Indexed for MEDLINE]
Free PMC Article

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