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Extracellular vesicles as modulators of wound healing.
Cabral J, Ryan AE, Griffin MD, Ritter T. Cabral J, et al. Adv Drug Deliv Rev. 2018 Apr;129:394-406. doi: 10.1016/j.addr.2018.01.018. Epub 2018 Jan 31. Adv Drug Deliv Rev. 2018. PMID: 29408181 Review.
Impaired healing of cutaneous wounds and ulcers continues to have a major impact on the quality of life of millions of people. ...This review addresses current evidence in support of stem/progenitor cell-derived extracellular vesicles (EVs) as a regenerative …
Impaired healing of cutaneous wounds and ulcers continues to have a major impact on the quality of life of millions of people. ...Thi …
Mesenchymal Stem Cell-Derived Exosomes: Applications in Regenerative Medicine.
Hade MD, Suire CN, Suo Z. Hade MD, et al. Cells. 2021 Aug 1;10(8):1959. doi: 10.3390/cells10081959. Cells. 2021. PMID: 34440728 Free PMC article. Review.
Exosomes are a type of extracellular vesicles, produced within multivesicular bodies, that are then released into the extracellular space through a merging of the multivesicular body with the plasma membrane. ...We also discuss emerging healing propert …
Exosomes are a type of extracellular vesicles, produced within multivesicular bodies, that are then released into the extra …
Exosomes from adipose-derived stem cells and application to skin wound healing.
An Y, Lin S, Tan X, Zhu S, Nie F, Zhen Y, Gu L, Zhang C, Wang B, Wei W, Li D, Wu J. An Y, et al. Cell Prolif. 2021 Mar;54(3):e12993. doi: 10.1111/cpr.12993. Epub 2021 Jan 17. Cell Prolif. 2021. PMID: 33458899 Free PMC article. Review.
Skin wound healing is an intractable problem that represents an urgent clinical need. ...This review describes the mechanisms whereby ADSCs-EXOs regulate wound healing and their clinical application. In the wound, ADSCs-EXOs modulate immu …
Skin wound healing is an intractable problem that represents an urgent clinical need. ...This review describes the mechanisms …
Mesenchymal stromal cells: promising treatment for liver cirrhosis.
Yao L, Hu X, Dai K, Yuan M, Liu P, Zhang Q, Jiang Y. Yao L, et al. Stem Cell Res Ther. 2022 Jul 15;13(1):308. doi: 10.1186/s13287-022-03001-z. Stem Cell Res Ther. 2022. PMID: 35841079 Free PMC article. Review.
Liver fibrosis is a wound-healing process that occurs in response to severe injuries and is hallmarked by the excessive accumulation of extracellular matrix or scar tissues within the liver. ...MSCs can also release a huge variety of molecules into the ext …
Liver fibrosis is a wound-healing process that occurs in response to severe injuries and is hallmarked by the excessive accumu …
Extracellular Vesicles in Skin Wound Healing.
Narauskaitė D, Vydmantaitė G, Rusteikaitė J, Sampath R, Rudaitytė A, Stašytė G, Aparicio Calvente MI, Jekabsone A. Narauskaitė D, et al. Pharmaceuticals (Basel). 2021 Aug 18;14(8):811. doi: 10.3390/ph14080811. Pharmaceuticals (Basel). 2021. PMID: 34451909 Free PMC article. Review.
For these cases, scientists are searching for new therapeutic interventions, from which one of the most promising is the use of extracellular vesicles (EVs). Naturally, EV-based signaling takes part in all four wound healing phases: hemostasis, inflamm …
For these cases, scientists are searching for new therapeutic interventions, from which one of the most promising is the use of extracell …
Exosomes-loaded thermosensitive hydrogels for corneal epithelium and stroma regeneration.
Tang Q, Lu B, He J, Chen X, Fu Q, Han H, Luo C, Yin H, Qin Z, Lyu D, Zhang L, Zhou M, Yao K. Tang Q, et al. Biomaterials. 2022 Jan;280:121320. doi: 10.1016/j.biomaterials.2021.121320. Epub 2021 Dec 11. Biomaterials. 2022. PMID: 34923312
To treat these diseases, herein, we developed a novel approach based on the exosome derived from induced pluripotent stem cell-derived mesenchymal stem cells (iPSC-MSCs) combined with a thermosensitive hydrogel, which reduces scar formation and accelerates the healing proc …
To treat these diseases, herein, we developed a novel approach based on the exosome derived from induced pluripotent stem cell-derived mesen …
Exosome-derived circTRPS1 promotes malignant phenotype and CD8+ T cell exhaustion in bladder cancer microenvironments.
Yang C, Wu S, Mou Z, Zhou Q, Dai X, Ou Y, Chen X, Chen Y, Xu C, Hu Y, Zhang L, Zou L, Jin S, Hu J, Mao S, Jiang H. Yang C, et al. Mol Ther. 2022 Mar 2;30(3):1054-1070. doi: 10.1016/j.ymthe.2022.01.022. Epub 2022 Jan 14. Mol Ther. 2022. PMID: 35038580 Free PMC article.
RNA pull-down, RNA immunoprecipitation, and luciferase reporter assays were used to investigate the interactions between specific circRNAs, microRNAs (miRNAs), and mRNAs. Wound-healing, Transwell, Cell Counting Kit-8 (CCK8), and colony-formation assays were used to …
RNA pull-down, RNA immunoprecipitation, and luciferase reporter assays were used to investigate the interactions between specific circRNAs, …
Exosomes derived from human adipose mesenchymal stem cells attenuate hypertrophic scar fibrosis by miR-192-5p/IL-17RA/Smad axis.
Li Y, Zhang J, Shi J, Liu K, Wang X, Jia Y, He T, Shen K, Wang Y, Liu J, Zhang W, Wang H, Zheng Z, Hu D. Li Y, et al. Stem Cell Res Ther. 2021 Mar 31;12(1):221. doi: 10.1186/s13287-021-02290-0. Stem Cell Res Ther. 2021. PMID: 33789737 Free PMC article.
Besides, the mice in ADSC-Exo-treated group demonstrated faster wound healing and less collagen deposition. Furthermore, miR-192-5p was highly expressed in ADSC-Exo and ADSC-Exosomal miR-192-5p ameliorated hypertrophic scar fibrosis. ...Moreover, IL-17RA was overexp …
Besides, the mice in ADSC-Exo-treated group demonstrated faster wound healing and less collagen deposition. Furthermore, miR-1 …
Extracellular vesicles modulate key signalling pathways in refractory wound healing.
Yang B, Lin Y, Huang Y, Zhu N, Shen YQ. Yang B, et al. Burns Trauma. 2023 Nov 16;11:tkad039. doi: 10.1093/burnst/tkad039. eCollection 2023. Burns Trauma. 2023. PMID: 38026441 Free PMC article. Review.
Numerous studies have shown that extracellular vesicles (EVs) derived from stem/progenitor cells promote wound healing, reduce scar formation and have significant advantages over traditional treatment methods. ...In this review, we summarize the recent …
Numerous studies have shown that extracellular vesicles (EVs) derived from stem/progenitor cells promote wound heali …
Extracellular vesicles derived from M1 macrophages deliver miR-146a-5p and miR-146b-5p to suppress trophoblast migration and invasion by targeting TRAF6 in recurrent spontaneous abortion.
Ding J, Zhang Y, Cai X, Zhang Y, Yan S, Wang J, Zhang S, Yin T, Yang C, Yang J. Ding J, et al. Theranostics. 2021 Mar 31;11(12):5813-5830. doi: 10.7150/thno.58731. eCollection 2021. Theranostics. 2021. PMID: 33897883 Free PMC article.
Methods: Extracellular vesicles (EVs) were isolated from the supernatant of M1 macrophages inducted from THP-1 cells (M1-EVs) by ultracentrifugation, identified by transmission electron microscopy, nanoparticle tracking analysis, and western blotting, and their miRN …
Methods: Extracellular vesicles (EVs) were isolated from the supernatant of M1 macrophages inducted from THP-1 cells (M1-EVs) …
169 results