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Page 1
Exploring the expanding universe of small RNAs.
Shi J, Zhou T, Chen Q. Shi J, et al. Among authors: chen q. Nat Cell Biol. 2022 Apr;24(4):415-423. doi: 10.1038/s41556-022-00880-5. Epub 2022 Apr 12. Nat Cell Biol. 2022. PMID: 35414016 Free PMC article. Review.
Here we discuss recent tools for sncRNA identification, caveats in sncRNA expression analysis and emerging methods for direct sequencing of sncRNAs and systematic mapping of RNA modifications that are integral to their function....
Here we discuss recent tools for sncRNA identification, caveats in sncRNA expression analysis and emerging methods for direct sequencing of …
Origins and evolving functionalities of tRNA-derived small RNAs.
Chen Q, Zhang X, Shi J, Yan M, Zhou T. Chen Q, et al. Trends Biochem Sci. 2021 Oct;46(10):790-804. doi: 10.1016/j.tibs.2021.05.001. Epub 2021 May 27. Trends Biochem Sci. 2021. PMID: 34053843 Free PMC article. Review.
Emerging studies have begun to reveal the versatile roles of tsRNAs in fundamental biological processes, including gene silencing, ribosome biogenesis, retrotransposition, and epigenetic inheritance, which are rooted in tsRNA sequence conservation, RNA modifications …
Emerging studies have begun to reveal the versatile roles of tsRNAs in fundamental biological processes, including gene silencing, ribosome …
Sperm tsRNAs contribute to intergenerational inheritance of an acquired metabolic disorder.
Chen Q, Yan M, Cao Z, Li X, Zhang Y, Shi J, Feng GH, Peng H, Zhang X, Zhang Y, Qian J, Duan E, Zhai Q, Zhou Q. Chen Q, et al. Science. 2016 Jan 22;351(6271):397-400. doi: 10.1126/science.aad7977. Epub 2015 Dec 31. Science. 2016. PMID: 26721680
In a paternal mouse model given a high-fat diet (HFD), we showed that a subset of sperm transfer RNA-derived small RNAs (tsRNAs), mainly from 5' transfer RNA halves and ranging in size from 30 to 34 nucleotides, exhibited changes in expression profiles and RNA modificat …
In a paternal mouse model given a high-fat diet (HFD), we showed that a subset of sperm transfer RNA-derived small RNAs (tsRNAs), mainly fro …
PANDORA-seq expands the repertoire of regulatory small RNAs by overcoming RNA modifications.
Shi J, Zhang Y, Tan D, Zhang X, Yan M, Zhang Y, Franklin R, Shahbazi M, Mackinlay K, Liu S, Kuhle B, James ER, Zhang L, Qu Y, Zhai Q, Zhao W, Zhao L, Zhou C, Gu W, Murn J, Guo J, Carrell DT, Wang Y, Chen X, Cairns BR, Yang XL, Schimmel P, Zernicka-Goetz M, Cheloufi S, Zhang Y, Zhou T, Chen Q. Shi J, et al. Among authors: chen q. Nat Cell Biol. 2021 Apr;23(4):424-436. doi: 10.1038/s41556-021-00652-7. Epub 2021 Apr 5. Nat Cell Biol. 2021. PMID: 33820973 Free PMC article.
Although high-throughput RNA sequencing (RNA-seq) has greatly advanced small non-coding RNA (sncRNA) discovery, the currently widely used complementary DNA library construction protocol generates biased sequencing results. This is partially due to RNA modifications …
Although high-throughput RNA sequencing (RNA-seq) has greatly advanced small non-coding RNA (sncRNA) discovery, the currently widely used co …
Small RNA Modifications: Integral to Function and Disease.
Zhang X, Cozen AE, Liu Y, Chen Q, Lowe TM. Zhang X, et al. Among authors: chen q. Trends Mol Med. 2016 Dec;22(12):1025-1034. doi: 10.1016/j.molmed.2016.10.009. Epub 2016 Nov 11. Trends Mol Med. 2016. PMID: 27840066 Free PMC article. Review.
Emerging evidence has shown that small RNAs including microRNAs (miRNAs), PIWI-interacting RNAs (piRNAs) and tRNA-derived small RNAs (tsRNAs) harbor a diversity of RNA modifications. These findings highlight the importance of RNA modifications in the m …
Emerging evidence has shown that small RNAs including microRNAs (miRNAs), PIWI-interacting RNAs (piRNAs) and tRNA-derived small RNAs (tsRNAs …
Sperm RNA code programmes the metabolic health of offspring.
Zhang Y, Shi J, Rassoulzadegan M, Tuorto F, Chen Q. Zhang Y, et al. Among authors: chen q. Nat Rev Endocrinol. 2019 Aug;15(8):489-498. doi: 10.1038/s41574-019-0226-2. Epub 2019 Jun 24. Nat Rev Endocrinol. 2019. PMID: 31235802 Free PMC article. Review.
Our understanding of the categories of sperm RNAs (such as tRNA-derived small RNAs, microRNAs, ribosomal RNA-derived small RNAs and long non-coding RNAs) and associated RNA modifications is expanding and has begun to reveal the functional diversity and information c …
Our understanding of the categories of sperm RNAs (such as tRNA-derived small RNAs, microRNAs, ribosomal RNA-derived small RNAs and long non …
Emerging functional principles of tRNA-derived small RNAs and other regulatory small RNAs.
Chen Q, Zhou T. Chen Q, et al. J Biol Chem. 2023 Oct;299(10):105225. doi: 10.1016/j.jbc.2023.105225. Epub 2023 Sep 9. J Biol Chem. 2023. PMID: 37673341 Free PMC article. Review.
Aptamers use 3D structure for specific interactions with ligands and are modulated by RNA modifications and subcellular environments. Given that aptamer-like sncRNA functions are widespread and present in species lacking RNAi, they may represent an ancient functiona …
Aptamers use 3D structure for specific interactions with ligands and are modulated by RNA modifications and subcellular enviro …
Small RNA modifications in Alzheimer's disease.
Zhang X, Trebak F, Souza LAC, Shi J, Zhou T, Kehoe PG, Chen Q, Feng Earley Y. Zhang X, et al. Among authors: chen q. Neurobiol Dis. 2020 Nov;145:105058. doi: 10.1016/j.nbd.2020.105058. Epub 2020 Aug 21. Neurobiol Dis. 2020. PMID: 32835860 Free PMC article.
Methods We performed LC-MS/MS-based, high-throughput assays of small RNA modifications in post-mortem samples of the prefrontal lobe cortices of Alzheimer's disease (AD) and control individuals. ...Interestingly, most of these altered RNA modifications …
Methods We performed LC-MS/MS-based, high-throughput assays of small RNA modifications in post-mortem samples of the prefronta …
PANDORA-Seq unveils the hidden small noncoding RNA landscape in atherosclerosis of LDL receptor-deficient mice.
Hernandez R, Shi J, Liu J, Li X, Wu J, Zhao L, Zhou T, Chen Q, Zhou C. Hernandez R, et al. Among authors: chen q. J Lipid Res. 2023 Apr;64(4):100352. doi: 10.1016/j.jlr.2023.100352. Epub 2023 Mar 4. J Lipid Res. 2023. PMID: 36871792 Free PMC article.
To address this technical obstacle, we recently developed a novel PANDORA-Seq (Panoramic RNA Display by Overcoming RNA Modification Aborted Sequencing) method to overcome RNA modification-elicited sequence interferences. ...Total RNAs isolated from the …
To address this technical obstacle, we recently developed a novel PANDORA-Seq (Panoramic RNA Display by Overcoming RNA Modificatio …
Epigenetic inheritance of acquired traits through sperm RNAs and sperm RNA modifications.
Chen Q, Yan W, Duan E. Chen Q, et al. Nat Rev Genet. 2016 Dec;17(12):733-743. doi: 10.1038/nrg.2016.106. Epub 2016 Oct 3. Nat Rev Genet. 2016. PMID: 27694809 Free PMC article. Review.
The search for epigenetic factors in mammalian sperm that transmit acquired phenotypes has recently focused on RNAs and, more recently, RNA modifications. Here, we review insights that have been gained from studying sperm RNAs and RNA modifications, an …
The search for epigenetic factors in mammalian sperm that transmit acquired phenotypes has recently focused on RNAs and, more recently, R …
19 results