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Items: 1 to 20 of 67


Snx27 Deletion Promotes Recovery From Spinal Cord Injury by Neuroprotection and Reduces Macrophage/Microglia Proliferation.

Zeng Y, Wang N, Guo T, Zheng Q, Wang S, Wu S, Li X, Wu J, Chen Z, Xu H, Wang X, Lin B.

Front Neurol. 2018 Dec 13;9:1059. doi: 10.3389/fneur.2018.01059. eCollection 2018.


Blood-Brain Barrier Integrity and Clearance of Amyloid-β from the BBB.

Cockerill I, Oliver JA, Xu H, Fu BM, Zhu D.

Adv Exp Med Biol. 2018;1097:261-278. doi: 10.1007/978-3-319-96445-4_14.


RPS23RG1 Is Required for Synaptic Integrity and Rescues Alzheimer's Disease-Associated Cognitive Deficits.

Zhao D, Meng J, Zhao Y, Huo Y, Liu Y, Zheng N, Zhang M, Gao Y, Chen Z, Sun H, Wang X, Jing C, Zhang T, Zhang X, Luo H, Wang X, Zhang J, Liu FR, Li Y, Bu G, Wen L, Huang TY, Xu H, Zhang YW.

Biol Psychiatry. 2018 Aug 25. pii: S0006-3223(18)31782-7. doi: 10.1016/j.biopsych.2018.08.009. [Epub ahead of print]


Menin Deficiency Leads to Depressive-like Behaviors in Mice by Modulating Astrocyte-Mediated Neuroinflammation.

Leng L, Zhuang K, Liu Z, Huang C, Gao Y, Chen G, Lin H, Hu Y, Wu D, Shi M, Xie W, Sun H, Shao Z, Li H, Zhang K, Mo W, Huang TY, Xue M, Yuan Z, Zhang X, Bu G, Xu H, Xu Q, Zhang J.

Neuron. 2018 Nov 7;100(3):551-563.e7. doi: 10.1016/j.neuron.2018.08.031. Epub 2018 Sep 13.


Arginine Methyltransferase PRMT8 Provides Cellular Stress Tolerance in Aging Motoneurons.

Simandi Z, Pajer K, Karolyi K, Sieler T, Jiang LL, Kolostyak Z, Sari Z, Fekecs Z, Pap A, Patsalos A, Contreras GA, Reho B, Papp Z, Guo X, Horvath A, Kiss G, Keresztessy Z, Vámosi G, Hickman J, Xu H, Dormann D, Hortobagyi T, Antal M, Nógrádi A, Nagy L.

J Neurosci. 2018 Aug 29;38(35):7683-7700. doi: 10.1523/JNEUROSCI.3389-17.2018. Epub 2018 Jul 27.


Neuron-Specific Menin Deletion Leads to Synaptic Dysfunction and Cognitive Impairment by Modulating p35 Expression.

Zhuang K, Huang C, Leng L, Zheng H, Gao Y, Chen G, Ji Z, Sun H, Hu Y, Wu D, Shi M, Li H, Zhao Y, Zhang Y, Xue M, Bu G, Huang TY, Xu H, Zhang J.

Cell Rep. 2018 Jul 17;24(3):701-712. doi: 10.1016/j.celrep.2018.06.055.


Compensatory Mechanisms Modulate the Neuronal Excitability in a Kainic Acid-Induced Epilepsy Mouse Model.

Pan G, Chen Z, Zheng H, Zhang Y, Xu H, Bu G, Zheng H, Li Y.

Front Neural Circuits. 2018 Jun 29;12:48. doi: 10.3389/fncir.2018.00048. eCollection 2018.


Therapeutic Potential of a Prolyl Hydroxylase Inhibitor FG-4592 for Parkinson's Diseases in Vitro and in Vivo: Regulation of Redox Biology and Mitochondrial Function.

Li X, Cui XX, Chen YJ, Wu TT, Xu H, Yin H, Wu YC.

Front Aging Neurosci. 2018 Apr 27;10:121. doi: 10.3389/fnagi.2018.00121. eCollection 2018.


B Cell-Mediated Maintenance of Cluster of Differentiation 169-Positive Cells Is Critical for Liver Regeneration.

Behnke K, Zhuang Y, Xu HC, Sundaram B, Reich M, Shinde PV, Huang J, Modares NF, Tumanov AV, Polz R, Scheller J, Ware CF, Pfeffer K, Keitel V, Häussinger D, Pandyra AA, Lang KS, Lang PA.

Hepatology. 2018 Dec;68(6):2348-2361. doi: 10.1002/hep.30088. Epub 2018 Nov 5.


Inhibition of PKCδ reduces amyloid-β levels and reverses Alzheimer disease phenotypes.

Du Y, Zhao Y, Li C, Zheng Q, Tian J, Li Z, Huang TY, Zhang W, Xu H.

J Exp Med. 2018 Jun 4;215(6):1665-1677. doi: 10.1084/jem.20171193. Epub 2018 May 8.


The Retromer Complex and Sorting Nexins in Neurodegenerative Diseases.

Zhang H, Huang T, Hong Y, Yang W, Zhang X, Luo H, Xu H, Wang X.

Front Aging Neurosci. 2018 Mar 26;10:79. doi: 10.3389/fnagi.2018.00079. eCollection 2018. Review.


Intracellular trafficking of TREM2 is regulated by presenilin 1.

Zhao Y, Li X, Huang T, Jiang LL, Tan Z, Zhang M, Cheng IH, Wang X, Bu G, Zhang YW, Wang Q, Xu H.

Exp Mol Med. 2017 Dec 1;49(12):e405. doi: 10.1038/emm.2017.200.


Amyloid-beta modulates microglial responses by binding to the triggering receptor expressed on myeloid cells 2 (TREM2).

Zhong L, Wang Z, Wang D, Wang Z, Martens YA, Wu L, Xu Y, Wang K, Li J, Huang R, Can D, Xu H, Bu G, Chen XF.

Mol Neurodegener. 2018 Mar 27;13(1):15. doi: 10.1186/s13024-018-0247-7.


Elevated TREM2 Gene Dosage Reprograms Microglia Responsivity and Ameliorates Pathological Phenotypes in Alzheimer's Disease Models.

Lee CYD, Daggett A, Gu X, Jiang LL, Langfelder P, Li X, Wang N, Zhao Y, Park CS, Cooper Y, Ferando I, Mody I, Coppola G, Xu H, Yang XW.

Neuron. 2018 Mar 7;97(5):1032-1048.e5. doi: 10.1016/j.neuron.2018.02.002.


TREM2 Is a Receptor for β-Amyloid that Mediates Microglial Function.

Zhao Y, Wu X, Li X, Jiang LL, Gui X, Liu Y, Sun Y, Zhu B, Piña-Crespo JC, Zhang M, Zhang N, Chen X, Bu G, An Z, Huang TY, Xu H.

Neuron. 2018 Mar 7;97(5):1023-1031.e7. doi: 10.1016/j.neuron.2018.01.031.


Magnesium Reduces Blood-Brain Barrier Permeability and Regulates Amyloid-β Transcytosis.

Zhu D, Su Y, Fu B, Xu H.

Mol Neurobiol. 2018 Sep;55(9):7118-7131. doi: 10.1007/s12035-018-0896-0. Epub 2018 Jan 30.


Tau-mediated Neurodegeneration and Potential Implications in Diagnosis and Treatment of Alzheimer's Disease.

Wu XL, Piña-Crespo J, Zhang YW, Chen XC, Xu HX.

Chin Med J (Engl). 2017 Dec 20;130(24):2978-2990. doi: 10.4103/0366-6999.220313. Review.


ER-associated degradation regulates Alzheimer's amyloid pathology and memory function by modulating γ-secretase activity.

Zhu B, Jiang L, Huang T, Zhao Y, Liu T, Zhong Y, Li X, Campos A, Pomeroy K, Masliah E, Zhang D, Xu H.

Nat Commun. 2017 Nov 13;8(1):1472. doi: 10.1038/s41467-017-01799-4.


NitroSynapsin therapy for a mouse MEF2C haploinsufficiency model of human autism.

Tu S, Akhtar MW, Escorihuela RM, Amador-Arjona A, Swarup V, Parker J, Zaremba JD, Holland T, Bansal N, Holohan DR, Lopez K, Ryan SD, Chan SF, Yan L, Zhang X, Huang X, Sultan A, McKercher SR, Ambasudhan R, Xu H, Wang Y, Geschwind DH, Roberts AJ, Terskikh AV, Rissman RA, Masliah E, Lipton SA, Nakanishi N.

Nat Commun. 2017 Nov 14;8(1):1488. doi: 10.1038/s41467-017-01563-8.


SORLA attenuates EphA4 signaling and amyloid β-induced neurodegeneration.

Huang TY, Zhao Y, Jiang LL, Li X, Liu Y, Sun Y, Piña-Crespo JC, Zhu B, Masliah E, Willnow TE, Pasquale EB, Xu H.

J Exp Med. 2017 Dec 4;214(12):3669-3685. doi: 10.1084/jem.20171413. Epub 2017 Nov 7.

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