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Clin Liver Dis. 2007 Aug;11(3):477-505, v.

Causality assessment of drug-induced hepatotoxicity: promises and pitfalls.

Author information

1
Hepatology Section, Division of Gastroenterology, Georgetown University Hospital, Georgetown University Medical Center, Washington, DC 20007, USA.

Abstract

Drug-induced liver injury is the leading cause of acute liver failure in the United States, but the ability to ascribe hepatic injury confidently to a specific drug remains a challenging and often difficult pursuit. This article explores the ongoing challenges inherent in what is currently a clinical process of elimination made in the attempt of assigning causality in drug-induced liver injury. In particular, it points out the shortcomings and pitfalls that often limit the applicability of the causality-assessment methodologies currently in use.

PMID:
17723916
DOI:
10.1016/j.cld.2007.06.003
[Indexed for MEDLINE]

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