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Quantification of a mercapturate metabolite of the biocides methylisothiazolinone and chloromethylisothiazolinone ("M-12") in human urine using online-SPE-LC/MS/MS.
Schettgen T, Bertram J, Weber T, Kraus T, Kolossa-Gehring M. Schettgen T, et al. Anal Methods. 2021 Apr 22;13(15):1847-1856. doi: 10.1039/d1ay00183c. Anal Methods. 2021. PMID: 33885679
To corroborate these findings, we have now developed a two-dimensional LC/MS/MS method for the quantification of a mercapturic acid metabolite of MI and MCI ((acetylamino){[3-(methylamino)-1-(methylthio)-3-oxopropyl]thio}acetic acid or shortly "M-12") …
To corroborate these findings, we have now developed a two-dimensional LC/MS/MS method for the quantification of a mercapturic acid metaboli …
Acetylcholine and tachykinin receptor antagonists attenuate wood smoke-induced bronchoconstriction in guinea pigs.
Hsu TH, Lai YL, Kou YR. Hsu TH, et al. Eur J Pharmacol. 1998 Nov 6;360(2-3):175-83. doi: 10.1016/s0014-2999(98)00690-6. Eur J Pharmacol. 1998. PMID: 9851584
The smoke-induced changes in RL and Cdyn were significantly attenuated by pretreatment with atropine, CP-96,345 [(2S,3S)-cis-2-(diphenylmethyl)-N-((2-methoxyphenyl)-methyl)-1-aza bicyclo(2.2.2.)-octan-3-amine; a tachykinin NK1 receptor antagonist], and SR-48,968 [( …
The smoke-induced changes in RL and Cdyn were significantly attenuated by pretreatment with atropine, CP-96,345 [(2S,3S)-cis-2-(diphenylmeth …
Acute neurogenic airway plasma exudation and edema induced by inhaled wood smoke in guinea pigs: role of tachykinins and hydroxyl radical.
Lin YS, Kou YR. Lin YS, et al. Eur J Pharmacol. 2000 Apr 7;394(1):139-48. doi: 10.1016/s0014-2999(00)00126-6. Eur J Pharmacol. 2000. PMID: 10771046
These acute airway responses were nearly abolished by pretreatment with CP-96,345 alone [a tachykinin NK(1) receptor antagonist; (2S, 3S)-cis-2-(diphenylmethyl)-N-((2-methoxyphenyl)-methyl)-1-azabicyc lo( 2.2.2.)-octan-3-amine] or with a combination of CP-96,345 and …
These acute airway responses were nearly abolished by pretreatment with CP-96,345 alone [a tachykinin NK(1) receptor antagonist; (2S, 3S)-ci …
Biochemical and pharmacological characterization of AZD1981, an orally available selective DP2 antagonist in clinical development for asthma.
Schmidt JA, Bell FM, Akam E, Marshall C, Dainty IA, Heinemann A, Dougall IG, Bonnert RV, Sargent CA. Schmidt JA, et al. Br J Pharmacol. 2013 Apr;168(7):1626-38. doi: 10.1111/bph.12053. Br J Pharmacol. 2013. PMID: 23146091 Free PMC article.
Here we describe the biochemical and pharmacological properties of 4-(acetylamino)-3-[(4-chlorophenyl)thio]-2-methyl-1H-indole-1-acetic acid (AZD1981), a novel DP2 receptor antagonist. ...
Here we describe the biochemical and pharmacological properties of 4-(acetylamino)-3-[(4-chlorophenyl)thio]-2-methyl …