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Quantifying Nucleation In Vivo Reveals the Physical Basis of Prion-like Phase Behavior.

Khan T, Kandola TS, Wu J, Venkatesan S, Ketter E, Lange JJ, Gama AR, Box A, Unruh JR, Cook M, Halfmann R.

Mol Cell. 2019 Feb 21;73(4):857. doi: 10.1016/j.molcel.2019.01.045. No abstract available.


Quantifying Nucleation In Vivo Reveals the Physical Basis of Prion-like Phase Behavior.

Khan T, Kandola TS, Wu J, Venkatesan S, Ketter E, Lange JJ, Rodríguez Gama A, Box A, Unruh JR, Cook M, Halfmann R.

Mol Cell. 2018 Jul 5;71(1):155-168.e7. doi: 10.1016/j.molcel.2018.06.016. Erratum in: Mol Cell. 2019 Feb 21;73(4):857.


A self-perpetuating repressive state of a viral replication protein blocks superinfection by the same virus.

Zhang XF, Sun R, Guo Q, Zhang S, Meulia T, Halfmann R, Li D, Qu F.

PLoS Pathog. 2017 Mar 7;13(3):e1006253. doi: 10.1371/journal.ppat.1006253. eCollection 2017 Mar.


A glass menagerie of low complexity sequences.

Halfmann R.

Curr Opin Struct Biol. 2016 Jun;38:18-25. doi: 10.1016/ Epub 2016 May 31. Review.


Thermal green protein, an extremely stable, nonaggregating fluorescent protein created by structure-guided surface engineering.

Close DW, Paul CD, Langan PS, Wilce MC, Traore DA, Halfmann R, Rocha RC, Waldo GS, Payne RJ, Rucker JB, Prescott M, Bradbury AR.

Proteins. 2015 Jul;83(7):1225-37. doi: 10.1002/prot.24699. Epub 2015 May 8.


Prion-like polymerization underlies signal transduction in antiviral immune defense and inflammasome activation.

Cai X, Chen J, Xu H, Liu S, Jiang QX, Halfmann R, Chen ZJ.

Cell. 2014 Mar 13;156(6):1207-1222. doi: 10.1016/j.cell.2014.01.063.


Heritable remodeling of yeast multicellularity by an environmentally responsive prion.

Holmes DL, Lancaster AK, Lindquist S, Halfmann R.

Cell. 2013 Mar 28;153(1):153-65. doi: 10.1016/j.cell.2013.02.026.


Small-molecule activation of the TRAIL receptor DR5 in human cancer cells.

Wang G, Wang X, Yu H, Wei S, Williams N, Holmes DL, Halfmann R, Naidoo J, Wang L, Li L, Chen S, Harran P, Lei X, Wang X.

Nat Chem Biol. 2013 Feb;9(2):84-9. doi: 10.1038/nchembio.1153. Epub 2012 Dec 23.


Prion formation by a yeast GLFG nucleoporin.

Halfmann R, Wright JR, Alberti S, Lindquist S, Rexach M.

Prion. 2012 Sep-Oct;6(4):391-9. doi: 10.4161/pri.20199. Epub 2012 May 7.


Prions are a common mechanism for phenotypic inheritance in wild yeasts.

Halfmann R, Jarosz DF, Jones SK, Chang A, Lancaster AK, Lindquist S.

Nature. 2012 Feb 15;482(7385):363-8. doi: 10.1038/nature10875.


Opposing effects of glutamine and asparagine govern prion formation by intrinsically disordered proteins.

Halfmann R, Alberti S, Krishnan R, Lyle N, O'Donnell CW, King OD, Berger B, Pappu RV, Lindquist S.

Mol Cell. 2011 Jul 8;43(1):72-84. doi: 10.1016/j.molcel.2011.05.013.


A method for probing the mutational landscape of amyloid structure.

O'Donnell CW, Waldispühl J, Lis M, Halfmann R, Devadas S, Lindquist S, Berger B.

Bioinformatics. 2011 Jul 1;27(13):i34-42. doi: 10.1093/bioinformatics/btr238.


Epigenetics in the extreme: prions and the inheritance of environmentally acquired traits.

Halfmann R, Lindquist S.

Science. 2010 Oct 29;330(6004):629-32. doi: 10.1126/science.1191081.


Biochemical, cell biological, and genetic assays to analyze amyloid and prion aggregation in yeast.

Alberti S, Halfmann R, Lindquist S.

Methods Enzymol. 2010;470:709-34. doi: 10.1016/S0076-6879(10)70030-6. Epub 2010 Mar 1.


Prions, protein homeostasis, and phenotypic diversity.

Halfmann R, Alberti S, Lindquist S.

Trends Cell Biol. 2010 Mar;20(3):125-33. doi: 10.1016/j.tcb.2009.12.003. Epub 2010 Jan 12.


A systematic survey identifies prions and illuminates sequence features of prionogenic proteins.

Alberti S, Halfmann R, King O, Kapila A, Lindquist S.

Cell. 2009 Apr 3;137(1):146-58. doi: 10.1016/j.cell.2009.02.044.


Screening for amyloid aggregation by Semi-Denaturing Detergent-Agarose Gel Electrophoresis.

Halfmann R, Lindquist S.

J Vis Exp. 2008 Jul 16;(17). pii: 838. doi: 10.3791/838.


Chaperone-dependent amyloid assembly protects cells from prion toxicity.

Douglas PM, Treusch S, Ren HY, Halfmann R, Duennwald ML, Lindquist S, Cyr DM.

Proc Natl Acad Sci U S A. 2008 May 20;105(20):7206-11. doi: 10.1073/pnas.0802593105. Epub 2008 May 14.


Influence of inflow cannula length in axial-flow pumps on neurologic adverse event rate: results from a multi-center analysis.

Schmid C, Jurmann M, Birnbaum D, Colombo T, Falk V, Feltrin G, Garatti A, Genoni M, Gerosa G, Göttel P, Gummert J, Halfmann R, Hammel D, Hennig E, Kaufmann F, Lanfranconi M, Meyns B, Mohr F, Müller J, Nikolov D, Rucinskas K, Scheld HH, Schmid FX, Schneider M, Sirvydis V, Tandler R, Vitali E, Vlasselaers D, Weyand M, Wilhelm M, Hetzer R.

J Heart Lung Transplant. 2008 Mar;27(3):253-60. doi: 10.1016/j.healun.2007.12.007.


Clinical results with an ePTFE inflow conduit for mechanical circulatory support.

Mussivand T, Hetzer R, Vitali E, Meyns B, Noirhomme P, Koerfer R, El-Banayosy A, Wolner E, Wieselthaler G, Reichart B, Uberfuhr P, Halfmann R, Portner P.

J Heart Lung Transplant. 2004 Dec;23(12):1366-70.


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