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See also: lrh1 lrh1 in the Gene database

lrh1 in Danio rerioHomo sapiens (2)All 10 Gene records

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Signaling through non-membrane nuclear phosphoinositide binding proteins in human health and disease.

Bryant JM, Blind RD.

J Lipid Res. 2018 Sep 10. pii: jlr.R088518. doi: 10.1194/jlr.R088518. [Epub ahead of print]


Local synthesis of immunosuppressive glucocorticoids in the intestinal epithelium regulates anti-viral immune responses.

Huang J, Jia R, Brunner T.

Cell Immunol. 2018 Aug 18. pii: S0008-8749(18)30206-5. doi: 10.1016/j.cellimm.2018.08.009. [Epub ahead of print]


Liver receptor homologue 1, a novel prognostic marker in colon cancer patients.

Wu C, Feng J, Li L, Wu Y, Xie H, Yin Y, Ye J, Li Z.

Oncol Lett. 2018 Sep;16(3):2833-2838. doi: 10.3892/ol.2018.8988. Epub 2018 Jun 18.


LRH-1 drives hepatocellular carcinoma partially through induction of c-myc and cyclin E1, and suppression of p21.

Xiao L, Wang Y, Liang W, Liu L, Pan N, Deng H, Li L, Zou C, Chan FL, Zhou Y.

Cancer Manag Res. 2018 Aug 1;10:2389-2400. doi: 10.2147/CMAR.S162887. eCollection 2018.


Association between LRH-1 single nucleotide polymorphisms and unexplained recurrent spontaneous abortion in Chinese Han couples.

Xu Z, Qu C, Li H, Yao L, Zhou Y, Liu L, Xu M, Qin Y.

Gynecol Endocrinol. 2018 Jul 25:1-3. doi: 10.1080/09513590.2018.1481945. [Epub ahead of print]


Liver Receptor Homolog-1 Regulates Organic Anion Transporter 2 and Docetaxel Pharmacokinetics.

Yu F, Zhang T, Guo L, Wu B.

Drug Metab Dispos. 2018 Jul;46(7):980-988. doi: 10.1124/dmd.118.080895. Epub 2018 Apr 18.


LRH-1 agonism favours an immune-islet dialogue which protects against diabetes mellitus.

Cobo-Vuilleumier N, Lorenzo PI, Rodríguez NG, Herrera Gómez IG, Fuente-Martin E, López-Noriega L, Mellado-Gil JM, Romero-Zerbo SY, Baquié M, Lachaud CC, Stifter K, Perdomo G, Bugliani M, De Tata V, Bosco D, Parnaud G, Pozo D, Hmadcha A, Florido JP, Toscano MG, de Haan P, Schoonjans K, Sánchez Palazón L, Marchetti P, Schirmbeck R, Martín-Montalvo A, Meda P, Soria B, Bermúdez-Silva FJ, St-Onge L, Gauthier BR.

Nat Commun. 2018 Apr 16;9(1):1488. doi: 10.1038/s41467-018-03943-0.


Regulation by FSH of the dynamic expression of retinol-binding protein 4 in the mouse ovary.

Jiang Y, Zhao Y, Chen S, Chen L, Li C, Zhou X.

Reprod Biol Endocrinol. 2018 Mar 20;16(1):25. doi: 10.1186/s12958-018-0348-8.


Protective role of microRNA-219-5p inhibitor against spinal cord injury via liver receptor homolog-1/Wnt/β-catenin signaling pathway regulation.

Li J, Li L, Shen Y.

Exp Ther Med. 2018 Apr;15(4):3563-3569. doi: 10.3892/etm.2018.5829. Epub 2018 Feb 1.


LRH-1 regulates hepatic lipid homeostasis and maintains arachidonoyl phospholipid pools critical for phospholipid diversity.

Miranda DA, Krause WC, Cazenave-Gassiot A, Suzawa M, Escusa H, Foo JC, Shihadih DS, Stahl A, Fitch M, Nyangau E, Hellerstein M, Wenk MR, Silver DL, Ingraham HA.

JCI Insight. 2018 Mar 8;3(5). pii: 96151. doi: 10.1172/jci.insight.96151. [Epub ahead of print]


Nuclear Receptor LRH-1 Functions to Promote Castration-Resistant Growth of Prostate Cancer via Its Promotion of Intratumoral Androgen Biosynthesis.

Xiao L, Wang Y, Xu K, Hu H, Xu Z, Wu D, Wang Z, You W, Ng CF, Yu S, Chan FL.

Cancer Res. 2018 May 1;78(9):2205-2218. doi: 10.1158/0008-5472.CAN-17-2341. Epub 2018 Feb 8.


miR-1275 controls granulosa cell apoptosis and estradiol synthesis by impairing LRH-1/CYP19A1 axis.

Liu J, Li X, Yao Y, Li Q, Pan Z, Li Q.

Biochim Biophys Acta Gene Regul Mech. 2018 Mar;1861(3):246-257. doi: 10.1016/j.bbagrm.2018.01.009. Epub 2018 Jan 31.


REV-ERBα Regulates CYP7A1 Through Repression of Liver Receptor Homolog-1.

Zhang T, Zhao M, Lu D, Wang S, Yu F, Guo L, Wen S, Wu B.

Drug Metab Dispos. 2018 Mar;46(3):248-258. doi: 10.1124/dmd.117.078105. Epub 2017 Dec 13.


MicroRNA-381 suppresses the proliferation of osteosarcoma cells through LRH-1/Wnt/β-catenin signaling pathway.

Wang Y, Sun S, Xu J, Luo Y, Xin Y, Zhao X.

Oncol Rep. 2018 Feb;39(2):589-596. doi: 10.3892/or.2017.6129. Epub 2017 Dec 4.


The liver receptor homolog-1 (LRH-1) is expressed in human islets and protects β-cells against stress-induced apoptosis.

Baquié M, St-Onge L, Kerr-Conte J, Cobo-Vuilleumier N, Lorenzo PI, Jimenez Moreno CM, Cederroth CR, Nef S, Borot S, Bosco D, Wang H, Marchetti P, Pattou F, Wollheim CB, Gauthier BR.

Hum Mol Genet. 2018 Jan 15;27(2):406. doi: 10.1093/hmg/ddx402. No abstract available.


Activation of PPARα decreases bile acids in livers of female mice while maintaining bile flow and biliary bile acid excretion.

Zhang Y, Lickteig AJ, Csanaky IL, Klaassen CD.

Toxicol Appl Pharmacol. 2018 Jan 1;338:112-123. doi: 10.1016/j.taap.2017.11.014. Epub 2017 Nov 22.


LRH-1 expression patterns in breast cancer tissues are associated with tumour aggressiveness.

Pang JB, Molania R, Chand A, Knower K, Takano EA, Byrne DJ, Mikeska T, Millar EKA, Lee CS, O'Toole SA, Clyne C, Gorringe KL, Dobrovic A, Fox SB.

Oncotarget. 2017 Jul 28;8(48):83626-83636. doi: 10.18632/oncotarget.18886. eCollection 2017 Oct 13.


MicroRNA-374b reduces the proliferation and invasion of colon cancer cells by regulation of LRH-1/Wnt signaling.

Qu R, Hao S, Jin X, Shi G, Yu Q, Tong X, Guo D.

Gene. 2018 Feb 5;642:354-361. doi: 10.1016/j.gene.2017.11.019. Epub 2017 Nov 8.


MicroRNA-381 serves as a prognostic factor and inhibits migration and invasion in non-small cell lung cancer by targeting LRH-1.

Tian C, Li J, Ren L, Peng R, Chen B, Lin Y.

Oncol Rep. 2017 Nov;38(5):3071-3077. doi: 10.3892/or.2017.5956. Epub 2017 Sep 14.


Nuclear receptor profiling in prostatospheroids and castration-resistant prostate cancer.

Wang Z, Wu D, Ng CF, Teoh JY, Yu S, Wang Y, Chan FL.

Endocr Relat Cancer. 2018 Jan;25(1):35-50. doi: 10.1530/ERC-17-0280. Epub 2017 Oct 17.


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