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Items: 1 to 20 of 91


Stochasticity from function - Why the Bayesian brain may need no noise.

Dold D, Bytschok I, Kungl AF, Baumbach A, Breitwieser O, Senn W, Schemmel J, Meier K, Petrovici MA.

Neural Netw. 2019 Nov;119:200-213. doi: 10.1016/j.neunet.2019.08.002. Epub 2019 Aug 19.


Soluble syndecan-3 binds chemokines, reduces leukocyte migration in vitro and ameliorates disease severity in models of rheumatoid arthritis.

Eustace AD, McNaughton EF, King S, Kehoe O, Kungl A, Mattey D, Nobbs AH, Williams N, Middleton J.

Arthritis Res Ther. 2019 Jul 12;21(1):172. doi: 10.1186/s13075-019-1939-2.


Increased Aggregation Tendency of Alpha-Synuclein in a Fully Disordered Protein Complex.

Merle DA, Witternigg A, Tam-Amersdorfer C, Hartlmüller C, Spreitzer E, Schrank E, Wagner-Lichtenegger S, Werzer O, Zangger K, Kungl AJ, Madl T, Meyer NH, Falsone SF.

J Mol Biol. 2019 Jun 28;431(14):2581-2598. doi: 10.1016/j.jmb.2019.04.031. Epub 2019 Apr 26.


Demonstrating Advantages of Neuromorphic Computation: A Pilot Study.

Wunderlich T, Kungl AF, Müller E, Hartel A, Stradmann Y, Aamir SA, Grübl A, Heimbrecht A, Schreiber K, Stöckel D, Pehle C, Billaudelle S, Kiene G, Mauch C, Schemmel J, Meier K, Petrovici MA.

Front Neurosci. 2019 Mar 26;13:260. doi: 10.3389/fnins.2019.00260. eCollection 2019.


Molecular dynamics simulations of the chemokine CCL2 in complex with pull down-derived heparan sulfate hexasaccharides.

Winkler S, Derler R, Gesslbauer B, Krieger E, Kungl AJ.

Biochim Biophys Acta Gen Subj. 2019 Mar;1863(3):528-533. doi: 10.1016/j.bbagen.2018.12.014. Epub 2018 Dec 23.


Therapeutic strategies to target microbial protein-glycosaminoglycan interactions.

Almer J, Gesslbauer B, Kungl AJ.

Biochem Soc Trans. 2018 Dec 17;46(6):1505-1515. doi: 10.1042/BST20170485. Epub 2018 Oct 31. Review.


Anti-inflammatory effects of the GAG-binding CXCL9(74-103) peptide in dinitrofluorobenzene-induced contact hypersensitivity in mice.

Vanheule V, Crijns H, Poosti F, Ruytinx P, Berghmans N, Gerlza T, Ronsse I, Pörtner N, Matthys P, Kungl AJ, Opdenakker G, Struyf S, Proost P.

Clin Exp Allergy. 2018 Oct;48(10):1333-1344. doi: 10.1111/cea.13227. Epub 2018 Aug 14.


Novel Anti-Inflammatory Peptides Based on Chemokine-Glycosaminoglycan Interactions Reduce Leukocyte Migration and Disease Severity in a Model of Rheumatoid Arthritis.

McNaughton EF, Eustace AD, King S, Sessions RB, Kay A, Farris M, Broadbridge R, Kehoe O, Kungl AJ, Middleton J.

J Immunol. 2018 May 1;200(9):3201-3217. doi: 10.4049/jimmunol.1701187. Epub 2018 Mar 23.


Glycosaminoglycan-Mediated Downstream Signaling of CXCL8 Binding to Endothelial Cells.

Derler R, Gesslbauer B, Weber C, Strutzmann E, Miller I, Kungl A.

Int J Mol Sci. 2017 Dec 4;18(12). pii: E2605. doi: 10.3390/ijms18122605.


CXCL9-Derived Peptides Differentially Inhibit Neutrophil Migration In Vivo through Interference with Glycosaminoglycan Interactions.

Vanheule V, Boff D, Mortier A, Janssens R, Petri B, Kolaczkowska E, Kubes P, Berghmans N, Struyf S, Kungl AJ, Teixeira MM, Amaral FA, Proost P.

Front Immunol. 2017 May 10;8:530. doi: 10.3389/fimmu.2017.00530. eCollection 2017.


Glycosaminoglycans are important mediators of neutrophilic inflammation in vivo.

Gschwandtner M, Strutzmann E, Teixeira MM, Anders HJ, Diedrichs-Möhring M, Gerlza T, Wildner G, Russo RC, Adage T, Kungl AJ.

Cytokine. 2017 Mar;91:65-73. doi: 10.1016/j.cyto.2016.12.008. Epub 2016 Dec 21.


Profiling the Membrane and Glycosaminoglycan-Binding Proteomes of Moraxella catarrhalis.

Karner A, Gesslbauer B, Spreitzer A, Almer J, Smidt M, Schüler W, Fartmann B, Zimmermann W, Meinke A, Kungl AJ.

J Proteome Res. 2016 Sep 2;15(9):3055-97. doi: 10.1021/acs.jproteome.6b00187. Epub 2016 Jul 29.


Interfering with the CCL2-glycosaminoglycan axis as a potential approach to modulate neuroinflammation.

Gschwandtner M, Piccinini AM, Gerlza T, Adage T, Kungl AJ.

Neurosci Lett. 2016 Jul 28;626:164-73. doi: 10.1016/j.neulet.2016.05.037. Epub 2016 May 19.


Exploring the glycosaminoglycan-protein interaction network by glycan-mediated pull-down proteomics.

Gesslbauer B, Derler R, Handwerker C, Seles E, Kungl AJ.

Electrophoresis. 2016 Jun;37(11):1437-47. doi: 10.1002/elps.201600043. Epub 2016 Apr 9.


Preparation and Characterization of Glycosaminoglycan Chemokine Coreceptors.

Kitic N, Gschwandtner M, Derler R, Gerlza T, Kungl AJ.

Methods Enzymol. 2016;570:517-38. doi: 10.1016/bs.mie.2015.09.018. Epub 2015 Nov 14.


Targeting of CCL2-CCR2-Glycosaminoglycan Axis Using a CCL2 Decoy Protein Attenuates Metastasis through Inhibition of Tumor Cell Seeding.

Roblek M, Strutzmann E, Zankl C, Adage T, Heikenwalder M, Atlic A, Weis R, Kungl A, Borsig L.

Neoplasia. 2016 Jan;18(1):49-59. doi: 10.1016/j.neo.2015.11.013.


PA401, a novel CXCL8-based biologic therapeutic with increased glycosaminoglycan binding, reduces bronchoalveolar lavage neutrophils and systemic inflammatory markers in a murine model of LPS-induced lung inflammation.

Adage T, Del Bene F, Fiorentini F, Doornbos RP, Zankl C, Bartley MR, Kungl AJ.

Cytokine. 2015 Dec;76(2):433-441. doi: 10.1016/j.cyto.2015.08.006. Epub 2015 Aug 21.


Glycosaminoglycan silencing by engineered CXCL12 variants.

Gschwandtner M, Trinker MU, Hecher B, Adage T, Ali S, Kungl AJ.

FEBS Lett. 2015 Sep 14;589(19 Pt B):2819-24. doi: 10.1016/j.febslet.2015.07.052. Epub 2015 Aug 20.


The Positively Charged COOH-terminal Glycosaminoglycan-binding CXCL9(74-103) Peptide Inhibits CXCL8-induced Neutrophil Extravasation and Monosodium Urate Crystal-induced Gout in Mice.

Vanheule V, Janssens R, Boff D, Kitic N, Berghmans N, Ronsse I, Kungl AJ, Amaral FA, Teixeira MM, Van Damme J, Proost P, Mortier A.

J Biol Chem. 2015 Aug 28;290(35):21292-304. doi: 10.1074/jbc.M115.649855. Epub 2015 Jul 16.


Reversible Oxidation of a Conserved Methionine in the Nuclear Export Sequence Determines Subcellular Distribution and Activity of the Fungal Nitrate Regulator NirA.

Gallmetzer A, Silvestrini L, Schinko T, Gesslbauer B, Hortschansky P, Dattenböck C, Muro-Pastor MI, Kungl A, Brakhage AA, Scazzocchio C, Strauss J.

PLoS Genet. 2015 Jul 1;11(7):e1005297. doi: 10.1371/journal.pgen.1005297. eCollection 2015 Jul.

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