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Items: 1 to 20 of 232

1.

Buparlisib in Patients With Recurrent Glioblastoma Harboring Phosphatidylinositol 3-Kinase Pathway Activation: An Open-Label, Multicenter, Multi-Arm, Phase II Trial.

Wen PY, Touat M, Alexander BM, Mellinghoff IK, Ramkissoon S, McCluskey CS, Pelton K, Haidar S, Basu SS, Gaffey SC, Brown LE, Martinez-Ledesma JE, Wu S, Kim J, Wei W, Park MA, Huse JT, Kuhn JG, Rinne ML, Colman H, Agar NYR, Omuro AM, DeAngelis LM, Gilbert MR, de Groot JF, Cloughesy TF, Chi AS, Roberts TM, Zhao JJ, Lee EQ, Nayak L, Heath JR, Horky LL, Batchelor TT, Beroukhim R, Chang SM, Ligon AH, Dunn IF, Koul D, Young GS, Prados MD, Reardon DA, Yung WKA, Ligon KL.

J Clin Oncol. 2019 Feb 4:JCO1801207. doi: 10.1200/JCO.18.01207. [Epub ahead of print]

PMID:
30715997
2.

T cell antigen discovery via trogocytosis.

Li G, Bethune MT, Wong S, Joglekar AV, Leonard MT, Wang JK, Kim JT, Cheng D, Peng S, Zaretsky JM, Su Y, Luo Y, Heath JR, Ribas A, Witte ON, Baltimore D.

Nat Methods. 2019 Feb;16(2):183-190. doi: 10.1038/s41592-018-0305-7. Epub 2019 Jan 28.

PMID:
30700903
3.

T cell antigen discovery via signaling and antigen-presenting bifunctional receptors.

Joglekar AV, Leonard MT, Jeppson JD, Swift M, Li G, Wong S, Peng S, Zaretsky JM, Heath JR, Ribas A, Bethune MT, Baltimore D.

Nat Methods. 2019 Feb;16(2):191-198. doi: 10.1038/s41592-018-0304-8. Epub 2019 Jan 28.

PMID:
30700902
4.

Integrated measurement of intracellular proteins and transcripts in single cells.

Xu AM, Liu Q, Takata KL, Jeoung S, Su Y, Antoshechkin I, Chen S, Thomson M, Heath JR.

Lab Chip. 2018 Oct 23;18(21):3251-3262. doi: 10.1039/c8lc00639c.

PMID:
30178802
5.

Isolation of a Structural Mechanism for Uncoupling T Cell Receptor Signaling from Peptide-MHC Binding.

Sibener LV, Fernandes RA, Kolawole EM, Carbone CB, Liu F, McAffee D, Birnbaum ME, Yang X, Su LF, Yu W, Dong S, Gee MH, Jude KM, Davis MM, Groves JT, Goddard WA 3rd, Heath JR, Evavold BD, Vale RD, Garcia KC.

Cell. 2018 Jul 26;174(3):672-687.e27. doi: 10.1016/j.cell.2018.06.017.

PMID:
30053426
6.

Surface Immobilization of Redox-Labile Fluorescent Probes: Enabling Single-Cell Co-Profiling of Aerobic Glycolysis and Oncogenic Protein Signaling Activities.

Li Z, Cheng H, Shao S, Lu X, Mo L, Tsang J, Zeng P, Guo Z, Wang S, Nathanson DA, Heath JR, Wei W, Xue M.

Angew Chem Int Ed Engl. 2018 Sep 3;57(36):11554-11558. doi: 10.1002/anie.201803034. Epub 2018 Aug 6.

PMID:
29992724
7.

Allosteric Inhibitor of KRas Identified Using a Barcoded Assay Microchip Platform.

McCarthy AM, Kim J, Museth AK, Henning RK, Heath JE, Winson E, Oh JJ, Liang J, Hong S, Heath JR.

Anal Chem. 2018 Aug 7;90(15):8824-8830. doi: 10.1021/acs.analchem.8b00706. Epub 2018 Jul 19.

PMID:
29979578
8.

Preinfusion polyfunctional anti-CD19 chimeric antigen receptor T cells are associated with clinical outcomes in NHL.

Rossi J, Paczkowski P, Shen YW, Morse K, Flynn B, Kaiser A, Ng C, Gallatin K, Cain T, Fan R, Mackay S, Heath JR, Rosenberg SA, Kochenderfer JN, Zhou J, Bot A.

Blood. 2018 Aug 23;132(8):804-814. doi: 10.1182/blood-2018-01-828343. Epub 2018 Jun 12.

9.

Correction to A Chemically Synthesized Capture Agent Enables the Selective, Sensitive, and Robust Electrochemical Detection of Anthrax Protective Antigen.

Farrow B, Hong SA, Romero EC, Lai B, Coppock MB, Deyle KM, Finch AS, Stratis-Cullum DN, Agnew HD, Yang S, Heath JR.

ACS Nano. 2018 May 22;12(5):5066. doi: 10.1021/acsnano.8b03441. Epub 2018 May 11. No abstract available.

PMID:
29749728
10.

Modulating the Folding Landscape of Superoxide Dismutase 1 with Targeted Molecular Binders.

Bunck DN, Atsavapranee B, Museth AK, VanderVelde D, Heath JR.

Angew Chem Int Ed Engl. 2018 May 22;57(21):6212-6215. doi: 10.1002/anie.201802269. Epub 2018 Apr 25.

PMID:
29645329
11.

Corrigendum: Epitope Targeting of Tertiary Protein Structure Enables Target-Guided Synthesis of a Potent In-Cell Inhibitor of Botulinum Neurotoxin.

Farrow B, Wong M, Malette J, Lai B, Deyle KM, Das S, Nag A, Agnew HD, Heath JR.

Angew Chem Int Ed Engl. 2018 Feb 5;57(6):1439. doi: 10.1002/anie.201712967. No abstract available.

PMID:
29377421
12.

A kinetic investigation of interacting, stimulated T cells identifies conditions for rapid functional enhancement, minimal phenotype differentiation, and improved adoptive cell transfer tumor eradication.

Zhou J, Bethune MT, Malkova N, Sutherland AM, Comin-Anduix B, Su Y, Baltimore D, Ribas A, Heath JR.

PLoS One. 2018 Jan 23;13(1):e0191634. doi: 10.1371/journal.pone.0191634. eCollection 2018.

13.

Epitope-Targeted Macrocyclic Peptide Ligand with Picomolar Cooperative Binding to Interleukin-17F.

Lai BT, Wilson JA, Malette Loredo J, Pitram SM, LaBerge NA, Heath JR, Agnew HD.

Chemistry. 2018 Mar 12;24(15):3760-3767. doi: 10.1002/chem.201704752. Epub 2018 Feb 19.

PMID:
29319889
14.

Single-cell analysis resolves the cell state transition and signaling dynamics associated with melanoma drug-induced resistance.

Su Y, Wei W, Robert L, Xue M, Tsoi J, Garcia-Diaz A, Homet Moreno B, Kim J, Ng RH, Lee JW, Koya RC, Comin-Anduix B, Graeber TG, Ribas A, Heath JR.

Proc Natl Acad Sci U S A. 2017 Dec 26;114(52):13679-13684. doi: 10.1073/pnas.1712064115. Epub 2017 Dec 11.

15.

High-throughput screening of rare metabolically active tumor cells in pleural effusion and peripheral blood of lung cancer patients.

Tang Y, Wang Z, Li Z, Kim J, Deng Y, Li Y, Heath JR, Wei W, Lu S, Shi Q.

Proc Natl Acad Sci U S A. 2017 Mar 7;114(10):2544-2549. doi: 10.1073/pnas.1612229114. Epub 2017 Feb 21. Erratum in: Proc Natl Acad Sci U S A. 2017 Apr 4;114(14 ):E2983.

16.

Domain-swapped T cell receptors improve the safety of TCR gene therapy.

Bethune MT, Gee MH, Bunse M, Lee MS, Gschweng EH, Pagadala MS, Zhou J, Cheng D, Heath JR, Kohn DB, Kuhns MS, Uckert W, Baltimore D.

Elife. 2016 Nov 8;5. pii: e19095. doi: 10.7554/eLife.19095.

17.

Protein catalyzed capture agents with tailored performance for in vitro and in vivo applications.

Coppock MB, Warner CR, Dorsey B, Orlicki JA, Sarkes DA, Lai BT, Pitram SM, Rohde RD, Malette J, Wilson JA, Kearney P, Fang KC, Law SM, Candelario SL, Farrow B, Finch AS, Agnew HD, Heath JR, Stratis-Cullum DN.

Biopolymers. 2017 Mar;108(2). doi: 10.1002/bip.22934.

PMID:
27539157
18.

Harry Kroto (1939-2016).

Heath JR, Curl RF.

Nature. 2016 May 26;533(7604):470. doi: 10.1038/533470a. No abstract available.

PMID:
27225112
19.

Intercellular signaling through secreted proteins induces free-energy gradient-directed cell movement.

Kravchenko-Balasha N, Shin YS, Sutherland A, Levine RD, Heath JR.

Proc Natl Acad Sci U S A. 2016 May 17;113(20):5520-5. doi: 10.1073/pnas.1602171113. Epub 2016 May 2.

20.

Single-Cell Phosphoproteomics Resolves Adaptive Signaling Dynamics and Informs Targeted Combination Therapy in Glioblastoma.

Wei W, Shin YS, Xue M, Matsutani T, Masui K, Yang H, Ikegami S, Gu Y, Herrmann K, Johnson D, Ding X, Hwang K, Kim J, Zhou J, Su Y, Li X, Bonetti B, Chopra R, James CD, Cavenee WK, Cloughesy TF, Mischel PS, Heath JR, Gini B.

Cancer Cell. 2016 Apr 11;29(4):563-573. doi: 10.1016/j.ccell.2016.03.012.

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