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Items: 1 to 20 of 24


Can 14-3-3 proteins serve as therapeutic targets for the treatment of metabolic diseases?

Diallo K, Oppong AK, Lim GE.

Pharmacol Res. 2019 Jan;139:199-206. doi: 10.1016/j.phrs.2018.11.021. Epub 2018 Nov 16. Review.


Scaffold Proteins: From Coordinating Signaling Pathways to Metabolic Regulation.

Mugabo Y, Lim GE.

Endocrinology. 2018 Nov 1;159(11):3615-3630. doi: 10.1210/en.2018-00705. Review.


Elucidation of the 14-3-3ζ interactome reveals critical roles of RNA-splicing factors during adipogenesis.

Mugabo Y, Sadeghi M, Fang NN, Mayor T, Lim GE.

J Biol Chem. 2018 May 4;293(18):6736-6750. doi: 10.1074/jbc.M117.816272. Epub 2018 Mar 12.


Reducing insulin via conditional partial gene ablation in adults reverses diet-induced weight gain.

Page MM, Skovsø S, Cen H, Chiu AP, Dionne DA, Hutchinson DF, Lim GE, Szabat M, Flibotte S, Sinha S, Nislow C, Rodrigues B, Johnson JD.

FASEB J. 2018 Mar;32(3):1196-1206. doi: 10.1096/fj.201700518R. Epub 2018 Jan 3.


Reduced Circulating Insulin Enhances Insulin Sensitivity in Old Mice and Extends Lifespan.

Templeman NM, Flibotte S, Chik JHL, Sinha S, Lim GE, Foster LJ, Nislow C, Johnson JD.

Cell Rep. 2017 Jul 11;20(2):451-463. doi: 10.1016/j.celrep.2017.06.048.


A causal role for hyperinsulinemia in obesity.

Templeman NM, Skovsø S, Page MM, Lim GE, Johnson JD.

J Endocrinol. 2017 Mar;232(3):R173-R183. doi: 10.1530/JOE-16-0449. Epub 2017 Jan 4. Review.


14-3-3ζ: A numbers game in adipocyte function?

Lim GE, Johnson JD.

Adipocyte. 2015 Dec 14;5(2):232-7. doi: 10.1080/21623945.2015.1120913. eCollection 2016 Apr-Jun.


Ywhaz/14-3-3ζ Deletion Improves Glucose Tolerance Through a GLP-1-Dependent Mechanism.

Lim GE, Piske M, Lulo JE, Ramshaw HS, Lopez AF, Johnson JD.

Endocrinology. 2016 Jul;157(7):2649-59. doi: 10.1210/en.2016-1016. Epub 2016 May 11.


Inter-domain tagging implicates caveolin-1 in insulin receptor trafficking and Erk signaling bias in pancreatic beta-cells.

Boothe T, Lim GE, Cen H, Skovsø S, Piske M, Li SN, Nabi IR, Gilon P, Johnson JD.

Mol Metab. 2016 Feb 10;5(5):366-378. doi: 10.1016/j.molmet.2016.01.009. eCollection 2016 May.


14-3-3ζ coordinates adipogenesis of visceral fat.

Lim GE, Albrecht T, Piske M, Sarai K, Lee JTC, Ramshaw HS, Sinha S, Guthridge MA, Acker-Palmer A, Lopez AF, Clee SM, Nislow C, Johnson JD.

Nat Commun. 2015 Jul 29;6:7671. doi: 10.1038/ncomms8671.


Effects of insulin on human pancreatic cancer progression modeled in vitro.

Chan MT, Lim GE, Skovsø S, Yang YH, Albrecht T, Alejandro EU, Hoesli CA, Piret JM, Warnock GL, Johnson JD.

BMC Cancer. 2014 Nov 6;14:814. doi: 10.1186/1471-2407-14-814.


14-3-3 proteins are essential signalling hubs for beta cell survival.

Lim GE, Piske M, Johnson JD.

Diabetologia. 2013 Apr;56(4):825-37. doi: 10.1007/s00125-012-2820-x. Epub 2013 Jan 26.


Hyperinsulinemia drives diet-induced obesity independently of brain insulin production.

Mehran AE, Templeman NM, Brigidi GS, Lim GE, Chu KY, Hu X, Botezelli JD, Asadi A, Hoffman BG, Kieffer TJ, Bamji SX, Clee SM, Johnson JD.

Cell Metab. 2012 Dec 5;16(6):723-37. doi: 10.1016/j.cmet.2012.10.019.


Musashi expression in β-cells coordinates insulin expression, apoptosis and proliferation in response to endoplasmic reticulum stress in diabetes.

Szabat M, Kalynyak TB, Lim GE, Chu KY, Yang YH, Asadi A, Gage BK, Ao Z, Warnock GL, Piret JM, Kieffer TJ, Johnson JD.

Cell Death Dis. 2011 Nov 24;2:e232. doi: 10.1038/cddis.2011.119.


Pancreatic β-cell Raf-1 is required for glucose tolerance, insulin secretion, and insulin 2 transcription.

Alejandro EU, Lim GE, Mehran AE, Hu X, Taghizadeh F, Pelipeychenko D, Baccarini M, Johnson JD.

FASEB J. 2011 Nov;25(11):3884-95. doi: 10.1096/fj.10-180349. Epub 2011 Aug 4.


The rho guanosine 5'-triphosphatase, cell division cycle 42, is required for insulin-induced actin remodeling and glucagon-like peptide-1 secretion in the intestinal endocrine L cell.

Lim GE, Xu M, Sun J, Jin T, Brubaker PL.

Endocrinology. 2009 Dec;150(12):5249-61. doi: 10.1210/en.2009-0508. Epub 2009 Oct 9.


Insulin regulates glucagon-like peptide-1 secretion from the enteroendocrine L cell.

Lim GE, Huang GJ, Flora N, LeRoith D, Rhodes CJ, Brubaker PL.

Endocrinology. 2009 Feb;150(2):580-91. doi: 10.1210/en.2008-0726. Epub 2008 Sep 25.


Cross talk between the insulin and Wnt signaling pathways: evidence from intestinal endocrine L cells.

Yi F, Sun J, Lim GE, Fantus IG, Brubaker PL, Jin T.

Endocrinology. 2008 May;149(5):2341-51. doi: 10.1210/en.2007-1142. Epub 2008 Feb 7.


Fetal and neonatal exposure to nicotine in Wistar rats results in increased beta cell apoptosis at birth and postnatal endocrine and metabolic changes associated with type 2 diabetes.

Holloway AC, Lim GE, Petrik JJ, Foster WG, Morrison KM, Gerstein HC.

Diabetologia. 2005 Dec;48(12):2661-6. Epub 2005 Nov 4.


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