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1.

An international perspective on hospitalized patients with viral community-acquired pneumonia.

Radovanovic D, Sotgiu G, Jankovic M, Mahesh PA, Marcos PJ, Abdalla MI, Di Pasquale MF, Gramegna A, Terraneo S, Blasi F, Santus P, Aliberti S, Reyes LF, Restrepo MI; GLIMP Study Group, Aruj PK, Attorri S, Barimboim E, Caeiro JP, Garzón MI, Cambursano VH, Ceccato A, Chertcoff J, Cordon Díaz A, de Vedia L, Ganaha MC, Lambert S, Lopardo G, Luna CM, Malberti AG, Morcillo N, Tartara S, Pensotti C, Pereyra B, Scapellato PG, Stagnaro JP, Shah S, Lötsch F, Thalhammer F, Anseeuw K, Francois CA, Van Braeckel E, Vincent JL, Djimon MZ, Aranha Nouér S, Chipev P, Encheva M, Miteva D, Petkova D, Balkissou AD, Pefura Yone EW, Mbatchou Ngahane BH, Shen N, Xu JF, Bustamante Rico CA, Buitrago R, Pereira Paternina FJ, Kayembe Ntumba JM, Vladic-Carevic V, Jakopovic M, Matkovic Z, Mitrecic I, Bouchy Jacobsson ML, Bro Christensen A, Heitmann Bødtger UC, Meyer CN, Vestergaard Jensen A, El-Said Abd El-Wahhab I, Elsayed Morsy N, Shafiek H, Sobh E, Abdulsemed KA, Bertrand F, Brun-Buisson C, de Montmollin E, Fartoukh M, Messika J, Tattevin P, Khoury A, Ebruke B, Dreher M, Kolditz M, Meisinger M, Pletz MW, Hagel S, Rupp J, Schaberg T, Spielmanns M, Creutz P, Suttorp N, Siaw-Lartey B, Dimakou K, Papapetrou D, Tsigou E, Ampazis D, Kaimakamis E, Bhatia M, Dhar R, D'Souza G, Garg R, Koul PA, Jayaraj BS, Narayan KV, Udnur HB, Krishnamurthy SB, Kant S, Swarnakar R, Salvi S, Limaye S, Golshani K, Keatings VM, Martin-Loeches I, Maor Y, Strahilevitz J, Battaglia S, Carrabba M, Ceriana P, Confalonieri M, d'Arminio Monforte A, Del Prato B, De Rosa M, Fantini R, Fiorentino G, Gammino MA, Menzella F, Milani G, Nava S, Palmiero G, Petrino R, Gabrielli B, Rossi P, Sorino C, Steinhilber G, Zanforlin A, Franzetti F, Carone M, Patella V, Scarlata S, Comel A, Kurahashi K, Aoun Bacha Z, Barajas Ugalde D, Ceballos Zuñiga O, Villegas JF, Medenica M, van de Garde EMW, Raj Mihsra D, Shrestha P, Ridgeon E, Ishola Awokola B, Nwankwo ONO, Olufunlola AB, Olumide S, Ukwaja KN, Irfan M, Minarowski L, Szymon S, Froes F, Leuschner P, Meireles M, Ferrão C, Leuschner P, Neves J, Ravara SB, Brocovschii V, Ion C, Rusu D, Toma C, Chirita D, Dorobat CM, Birkun A, Kaluzhenina A, Almotairi A, Bukhary ZAA, Edathodu J, Fathy A, Mushira Abdulaziz Enani A, Eltayeb Mohamed N, Ulhadi Memon J, Bella A, Bogdanović N, Milenkovic B, Pesut D, Borderìas L, Bordon Garcia NM, Cabello Alarcón H, Cilloniz C, Torres A, Diaz-Brito V, Casas X, Encabo González A, Fernández-Almira ML, Gallego M, Gaspar-GarcÍa I, González Del Castillo J, Javaloyes Victoria P, Laserna Martínez E, Malo de Molina R, Menéndez R, Pando-Sandoval A, Prat Aymerich C, Lacoma de la Torre A, García-Olivé I, Rello J, Moyano S, Sanz F, Sibila O, Rodrigo-Troyano A, Solé-Violán J, Uranga A, van Boven JFM, Vendrell Torra E, Pujol JA, Feldman C, Kee Yum H, Fiogbe AA, Yangui F, Bilaceroglu S, Dalar L, Yilmaz U, Bogomolov A, Elahi N, Dhasmana DJ, Feneley A, Hancock C, Hill AT, Rudran B, Ruiz-Buitrago S, Campbell M, Whitaker P, Youzguin A, Singanayagam A, Allen KS, Brito V, Dietz J, Dysart CE, Kellie SM, Franco-Sadud RA, Meier G, Gaga M, Holland TL, Bergin SP, Kheir F, Landmeier M, Lois M, Nair GB, Patel H, Reyes K, Rodriguez-Cintron W, Saito S, Soni NJ, Noda J, Hinojosa CI, Levine SM, Angel LF, Anzueto A, Scott Whitlow K, Hipskind J, Sukhija K, Totten V, Wunderink RG, Shah RD, Mateyo KJ, Carugati M, Morosi M, Monge E.

Eur J Intern Med. 2018 Nov 3. pii: S0953-6205(18)30413-8. doi: 10.1016/j.ejim.2018.10.020. [Epub ahead of print]

PMID:
30401576
2.

3D Organ Models - Revolution in Pharmacological Research?

Weinhart M, Hocke A, Hippenstiel S, Kurreck J, Hedtrich S.

Pharmacol Res. 2018 Nov 2. pii: S1043-6618(18)31357-4. doi: 10.1016/j.phrs.2018.11.002. [Epub ahead of print] Review.

PMID:
30395949
3.

Delay in antibiotic therapy results in fatal disease outcome in murine pneumococcal pneumonia.

Berger S, Goekeri C, Gupta SK, Vera J, Dietert K, Behrendt U, Lienau J, Wienhold SM, Gruber AD, Suttorp N, Witzenrath M, Nouailles G.

Crit Care. 2018 Nov 1;22(1):287. doi: 10.1186/s13054-018-2224-5.

4.

Ventilator-induced lung injury is aggravated by antibiotic mediated microbiota depletion in mice.

Wienhold SM, Macrì M, Nouailles G, Dietert K, Gurtner C, Gruber AD, Heimesaat MM, Lienau J, Schumacher F, Kleuser B, Opitz B, Suttorp N, Witzenrath M, Müller-Redetzky HC.

Crit Care. 2018 Oct 29;22(1):282. doi: 10.1186/s13054-018-2213-8.

5.

STING SNP R293Q Is Associated with a Decreased Risk of Aging-Related Diseases.

Hamann L, Ruiz-Moreno JS, Szwed M, Mossakowska M, Lundvall L, Schumann RR, Opitz B, Puzianowska-Kuznicka M.

Gerontology. 2018 Oct 26:1-10. doi: 10.1159/000492972. [Epub ahead of print]

PMID:
30368497
6.

Generation of a 3D Liver Model Comprising Human Extracellular Matrix in an Alginate/Gelatin-Based Bioink by Extrusion Bioprinting for Infection and Transduction Studies.

Hiller T, Berg J, Elomaa L, Röhrs V, Ullah I, Schaar K, Dietrich AC, Al-Zeer MA, Kurtz A, Hocke AC, Hippenstiel S, Fechner H, Weinhart M, Kurreck J.

Int J Mol Sci. 2018 Oct 12;19(10). pii: E3129. doi: 10.3390/ijms19103129.

7.

Selecting Patients for Lobar Lung Volume Reduction Therapy: What Quantitative Computed Tomography Parameters Matter?

Theilig DC, Huebner RH, Neumann K, Poellinger A, Doellinger F.

Rofo. 2018 Oct 11. doi: 10.1055/a-0638-0058. [Epub ahead of print]

8.

Optimization of cell-laden bioinks for 3D bioprinting and efficient infection with influenza A virus.

Berg J, Hiller T, Kissner MS, Qazi TH, Duda GN, Hocke AC, Hippenstiel S, Elomaa L, Weinhart M, Fahrenson C, Kurreck J.

Sci Rep. 2018 Sep 17;8(1):13877. doi: 10.1038/s41598-018-31880-x.

9.

Discovery of Asciminib (ABL001), an Allosteric Inhibitor of the Tyrosine Kinase Activity of BCR-ABL1.

Schoepfer J, Jahnke W, Berellini G, Buonamici S, Cotesta S, Cowan-Jacob SW, Dodd S, Drueckes P, Fabbro D, Gabriel T, Groell JM, Grotzfeld RM, Hassan AQ, Henry C, Iyer V, Jones D, Lombardo F, Loo A, Manley PW, Pellé X, Rummel G, Salem B, Warmuth M, Wylie AA, Zoller T, Marzinzik AL, Furet P.

J Med Chem. 2018 Sep 27;61(18):8120-8135. doi: 10.1021/acs.jmedchem.8b01040. Epub 2018 Sep 7.

PMID:
30137981
10.

A novel European H5N8 influenza A virus has increased virulence in ducks but low zoonotic potential.

Grund C, Hoffmann D, Ulrich R, Naguib M, Schinköthe J, Hoffmann B, Harder T, Saenger S, Zscheppang K, Tönnies M, Hippenstiel S, Hocke A, Wolff T, Beer M.

Emerg Microbes Infect. 2018 Jul 19;7(1):132. doi: 10.1038/s41426-018-0130-1.

11.

Long-Term Culture of Distal Airway Epithelial Cells Allows Differentiation Towards Alveolar Epithelial Cells Suited for Influenza Virus Studies.

Imai-Matsushima A, Martin-Sancho L, Karlas A, Imai S, Zoranovic T, Hocke AC, Mollenkopf HJ, Berger H, Meyer TF.

EBioMedicine. 2018 Jul;33:230-241. doi: 10.1016/j.ebiom.2018.05.032. Epub 2018 Jun 22.

12.

Resolvin E1 and its precursor 18R-HEPE restore mitochondrial function in inflammation.

Hecker M, Sommer N, Foch S, Hecker A, Hackstein H, Witzenrath M, Weissmann N, Seeger W, Mayer K.

Biochim Biophys Acta Mol Cell Biol Lipids. 2018 Sep;1863(9):1016-1028. doi: 10.1016/j.bbalip.2018.06.011. Epub 2018 Jun 12.

PMID:
29902569
13.

Bronchial Injury After Atrial Fibrillation Ablation Using the Second-Generation Cryoballoon.

Bellmann B, Hübner RH, Lin T, Paland M, Steiner F, Krause P, Tscholl V, Nagel P, Roser M, Suttorp N, Landmesser U, Rillig A.

Circ Arrhythm Electrophysiol. 2018 Mar;11(3):e005925. doi: 10.1161/CIRCEP.117.005925. No abstract available.

PMID:
29874170
14.

Optimising experimental research in respiratory diseases: an ERS statement.

Bonniaud P, Fabre A, Frossard N, Guignabert C, Inman M, Kuebler WM, Maes T, Shi W, Stampfli M, Uhlig S, White E, Witzenrath M, Bellaye PS, Crestani B, Eickelberg O, Fehrenbach H, Guenther A, Jenkins G, Joos G, Magnan A, Maitre B, Maus UA, Reinhold P, Vernooy JHJ, Richeldi L, Kolb M.

Eur Respir J. 2018 May 17;51(5). pii: 1702133. doi: 10.1183/13993003.02133-2017. Print 2018 May.

PMID:
29773606
15.

Antibiotic treatment-induced secondary IgA deficiency enhances susceptibility to Pseudomonas aeruginosa pneumonia.

Robak OH, Heimesaat MM, Kruglov AA, Prepens S, Ninnemann J, Gutbier B, Reppe K, Hochrein H, Suter M, Kirschning CJ, Marathe V, Buer J, Hornef MW, Schnare M, Schneider P, Witzenrath M, Bereswill S, Steinhoff U, Suttorp N, Sander LE, Chaput C, Opitz B.

J Clin Invest. 2018 Aug 1;128(8):3535-3545. doi: 10.1172/JCI97065. Epub 2018 Jul 16.

16.

N-aryl-piperidine-4-carboxamides as a novel class of potent inhibitors of MALT1 proteolytic activity.

Schlapbach A, Revesz L, Pissot Soldermann C, Zoller T, Régnier CH, Bornancin F, Radimerski T, Blank J, Schuffenhauer A, Renatus M, Erbel P, Melkko S, Heng R, Simic O, Endres R, Wartmann M, Quancard J.

Bioorg Med Chem Lett. 2018 Jul 1;28(12):2153-2158. doi: 10.1016/j.bmcl.2018.05.017. Epub 2018 May 9.

PMID:
29759726
17.

Cystathionine γ-Lyase-Produced Hydrogen Sulfide Controls Endothelial NO Bioavailability and Blood Pressure.

Szijártó IA, Markó L, Filipovic MR, Miljkovic JL, Tabeling C, Tsvetkov D, Wang N, Rabelo LA, Witzenrath M, Diedrich A, Tank J, Akahoshi N, Kamata S, Ishii I, Gollasch M.

Hypertension. 2018 Jun;71(6):1210-1217. doi: 10.1161/HYPERTENSIONAHA.117.10562. Epub 2018 Apr 30.

PMID:
29712741
18.

DNA-release by Streptococcus pneumoniae autolysin LytA induced Krueppel-like factor 4 expression in macrophages.

Herta T, Bhattacharyya A, Bollensdorf C, Kabus C, García P, Suttorp N, Hippenstiel S, Zahlten J.

Sci Rep. 2018 Apr 10;8(1):5723. doi: 10.1038/s41598-018-24152-1.

19.

Development of an Efficacious, Semisynthetic Glycoconjugate Vaccine Candidate against Streptococcus pneumoniae Serotype 1.

Schumann B, Reppe K, Kaplonek P, Wahlbrink A, Anish C, Witzenrath M, Pereira CL, Seeberger PH.

ACS Cent Sci. 2018 Mar 28;4(3):357-361. doi: 10.1021/acscentsci.7b00504. Epub 2018 Mar 14.

20.

Recognition of microbial viability via TLR8 drives TFH cell differentiation and vaccine responses.

Ugolini M, Gerhard J, Burkert S, Jensen KJ, Georg P, Ebner F, Volkers SM, Thada S, Dietert K, Bauer L, Schäfer A, Helbig ET, Opitz B, Kurth F, Sur S, Dittrich N, Gaddam S, Conrad ML, Benn CS, Blohm U, Gruber AD, Hutloff A, Hartmann S, Boekschoten MV, Müller M, Jungersen G, Schumann RR, Suttorp N, Sander LE.

Nat Immunol. 2018 Apr;19(4):386-396. doi: 10.1038/s41590-018-0068-4. Epub 2018 Mar 19.

PMID:
29556002

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