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Items: 1 to 20 of 225

1.

Bile Acid Synthesis: From Nature to the Chemical Modification and Synthesis and Their Applications as Drugs and Nutrients.

Šarenac TM, Mikov M.

Front Pharmacol. 2018 Sep 25;9:939. doi: 10.3389/fphar.2018.00939. eCollection 2018. Review.

2.

Human relevance of rodent liver tumour formation by constitutive androstane receptor (CAR) activators.

Lake BG.

Toxicol Res (Camb). 2018 Mar 12;7(4):697-717. doi: 10.1039/c8tx00008e. eCollection 2018 Jul 1. Review.

PMID:
30090615
3.

Case examples of an evaluation of the human relevance of the pyrethroids/pyrethrins-induced liver tumours in rodents based on the mode of action.

Yamada T.

Toxicol Res (Camb). 2018 Jan 16;7(4):681-696. doi: 10.1039/c7tx00288b. eCollection 2018 Jul 1. Review.

PMID:
30090614
4.

AhR signaling pathways and regulatory functions.

Larigot L, Juricek L, Dairou J, Coumoul X.

Biochim Open. 2018 Jun 11;7:1-9. doi: 10.1016/j.biopen.2018.05.001. eCollection 2018 Dec. Review.

5.

A current structural perspective on PXR and CAR in drug metabolism.

Buchman CD, Chai SC, Chen T.

Expert Opin Drug Metab Toxicol. 2018 Jun;14(6):635-647. doi: 10.1080/17425255.2018.1476488. Epub 2018 May 30. Review.

PMID:
29757018
6.

The Role of PPAR and Its Cross-Talk with CAR and LXR in Obesity and Atherosclerosis.

Xu P, Zhai Y, Wang J.

Int J Mol Sci. 2018 Apr 23;19(4). pii: E1260. doi: 10.3390/ijms19041260. Review.

7.

Cytochrome P450 Induction and Xeno-Sensing Receptors Pregnane X Receptor, Constitutive Androstane Receptor, Aryl Hydrocarbon Receptor and Peroxisome Proliferator-Activated Receptor α at the Crossroads of Toxicokinetics and Toxicodynamics.

Hakkola J, Bernasconi C, Coecke S, Richert L, Andersson TB, Pelkonen O.

Basic Clin Pharmacol Toxicol. 2018 Sep;123 Suppl 5:42-50. doi: 10.1111/bcpt.13004. Epub 2018 Apr 29. Review.

PMID:
29527807
8.

Genetic variations of the xenoreceptors NR1I2 and NR1I3 and their effect on drug disposition and response variability.

Mbatchi LC, Brouillet JP, Evrard A.

Pharmacogenomics. 2018 Jan;19(1):61-77. doi: 10.2217/pgs-2017-0121. Epub 2017 Dec 4. Review.

PMID:
29199543
9.

Hepatotoxicity of Herbal Supplements Mediated by Modulation of Cytochrome P450.

Brewer CT, Chen T.

Int J Mol Sci. 2017 Nov 8;18(11). pii: E2353. doi: 10.3390/ijms18112353. Review.

10.

Human relevance of rodent liver tumors: Key insights from a Toxicology Forum workshop on nongenotoxic modes of action.

Felter SP, Foreman JE, Boobis A, Corton JC, Doi AM, Flowers L, Goodman J, Haber LT, Jacobs A, Klaunig JE, Lynch AM, Moggs J, Pandiri A.

Regul Toxicol Pharmacol. 2018 Feb;92:1-7. doi: 10.1016/j.yrtph.2017.11.003. Epub 2017 Nov 4. Review.

11.

Cellular adaptation to xenobiotics: Interplay between xenosensors, reactive oxygen species and FOXO transcription factors.

Klotz LO, Steinbrenner H.

Redox Biol. 2017 Oct;13:646-654. doi: 10.1016/j.redox.2017.07.015. Epub 2017 Aug 3. Review.

12.

Targeting nuclear receptors for the treatment of fatty liver disease.

Tanaka N, Aoyama T, Kimura S, Gonzalez FJ.

Pharmacol Ther. 2017 Nov;179:142-157. doi: 10.1016/j.pharmthera.2017.05.011. Epub 2017 May 23. Review.

PMID:
28546081
13.

Bile acids and colon cancer: Is FXR the solution of the conundrum?

Gadaleta RM, Garcia-Irigoyen O, Moschetta A.

Mol Aspects Med. 2017 Aug;56:66-74. doi: 10.1016/j.mam.2017.04.002. Epub 2017 Apr 21. Review.

PMID:
28400119
14.

[Effect of hypoxia on expression of multidrug resistance protein 2 and its regulation mechanism].

Luo B, Li W, Wang R, Lu H, Yang T, Jia Z.

Zhong Nan Da Xue Xue Bao Yi Xue Ban. 2017 Jan 28;42(1):98-107. doi: 10.11817/j.issn.1672-7347.2017.01.016. Review. Chinese.

15.

Molecular mechanisms of PFOA-induced toxicity in animals and humans: Implications for health risks.

Li K, Gao P, Xiang P, Zhang X, Cui X, Ma LQ.

Environ Int. 2017 Feb;99:43-54. doi: 10.1016/j.envint.2016.11.014. Epub 2016 Nov 18. Review.

PMID:
27871799
16.

A brief history of the discovery of PXR and CAR as xenobiotic receptors.

Yan J, Xie W.

Acta Pharm Sin B. 2016 Sep;6(5):450-452. Epub 2016 Jul 21. Review.

17.

Insights into CYP2B6-mediated drug-drug interactions.

Hedrich WD, Hassan HE, Wang H.

Acta Pharm Sin B. 2016 Sep;6(5):413-425. Epub 2016 Aug 9. Review.

18.

Genetic Polymorphisms Affecting the Pharmacokinetics of Antiretroviral Drugs.

Calcagno A, Cusato J, D'Avolio A, Bonora S.

Clin Pharmacokinet. 2017 Apr;56(4):355-369. doi: 10.1007/s40262-016-0456-6. Review.

PMID:
27641153
19.

Pregnane X receptor, constitutive androstane receptor and hepatocyte nuclear factors as emerging players in cancer precision medicine.

De Mattia E, Cecchin E, Roncato R, Toffoli G.

Pharmacogenomics. 2016 Sep;17(14):1547-71. doi: 10.2217/pgs-2016-0095. Epub 2016 Aug 26. Review.

PMID:
27561454
20.

The regulation of human hepatic drug transporter expression by activation of xenobiotic-sensing nuclear receptors.

Amacher DE.

Expert Opin Drug Metab Toxicol. 2016 Dec;12(12):1463-1477. Epub 2016 Aug 22. Review.

PMID:
27548410

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