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Cell Rep. 2018 Aug 14;24(7):1687-1695.e4. doi: 10.1016/j.celrep.2018.07.050.

Three Distinct Sets of Connector Hubs Integrate Human Brain Function.

Author information

1
VISN 17 Center of Excellence for Research on Returning War Veterans, Waco, TX 76711, USA; Center for Vital Longevity, School of Behavioral and Brain Sciences, University of Texas at Dallas, Dallas, TX 75235, USA; Department of Psychology and Neuroscience, Baylor University, Waco, TX 76789, USA. Electronic address: evan.gordon@va.gov.
2
Department of Psychology, Georgetown University, Washington, DC 20057, USA; Feil Family Brain and Mind Research Institute, Weill Cornell Medical College, New York, NY 10065, USA.
3
Department of Neurology, Washington University in St. Louis, St. Louis, MO 63110, USA.
4
Department of Psychological and Brain Sciences, Washington University in St. Louis, St. Louis, MO 63110, USA; Laboratory of Brain and Cognition, National Institute of Mental Health, NIH, Bethesda, MD 20892, USA.
5
Department of Radiology, Washington University in St. Louis, St. Louis, MO 63110, USA; Department of Psychiatry, Washington University in St. Louis, St. Louis, MO 63110, USA.
6
Department of Neurology, Washington University in St. Louis, St. Louis, MO 63110, USA; Department of Radiology, Washington University in St. Louis, St. Louis, MO 63110, USA; Department of Neuroscience, Washington University in St. Louis, St. Louis, MO 63110, USA; Department of Pediatrics, Washington University in St. Louis, St. Louis, MO 63110, USA; Department of Psychiatry, Washington University in St. Louis, St. Louis, MO 63110, USA.
7
Department of Neurology, Washington University in St. Louis, St. Louis, MO 63110, USA; Department of Psychological and Brain Sciences, Washington University in St. Louis, St. Louis, MO 63110, USA; Department of Radiology, Washington University in St. Louis, St. Louis, MO 63110, USA; Department of Neuroscience, Washington University in St. Louis, St. Louis, MO 63110, USA; Department of Biomedical Engineering, Washington University in St. Louis, St. Louis, MO 63110, USA.
8
Department of Neurology, Washington University in St. Louis, St. Louis, MO 63110, USA; Department of Occupational Therapy, Washington University in St. Louis, St. Louis, MO 63110, USA; Department of Pediatrics, Washington University in St. Louis, St. Louis, MO 63110, USA.
9
VISN 17 Center of Excellence for Research on Returning War Veterans, Waco, TX 76711, USA; Center for Vital Longevity, School of Behavioral and Brain Sciences, University of Texas at Dallas, Dallas, TX 75235, USA; Department of Psychology and Neuroscience, Baylor University, Waco, TX 76789, USA.

Abstract

Control over behavior is enabled by the brain's control networks, which interact with lower-level sensory motor and default networks to regulate their functions. Such interactions are facilitated by specialized "connector hub" regions that interconnect discrete networks. Previous work has treated hubs as a single category of brain regions, although their unitary nature is dubious when examined in individual brains. Here we investigated the nature of hubs by using fMRI to characterize individual-specific hub regions in two independent datasets. We identified three separable sets of connector hubs that integrate information between specific brain networks. These three hub categories occupy different positions within the brain's network structure; they affect networks differently when artificially lesioned, and they are differentially engaged during cognitive and motor task performance. This work suggests a model of brain organization in which different connector hubs integrate control functions and enable top-down control of separate processing streams.

KEYWORDS:

brain networks; connector hubs; fMRI; functional connectivity

PMID:
30110625
DOI:
10.1016/j.celrep.2018.07.050
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