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Items: 18


A Context-Dependent Role for the RNF146 Ubiquitin Ligase in Wingless/Wnt Signaling in Drosophila.

Wang Z, Tacchelly-Benites O, Noble GP, Johnson MK, Gagné JP, Poirier GG, Ahmed Y.

Genetics. 2018 Dec 28. pii: genetics.301393.2018. doi: 10.1534/genetics.118.301393. [Epub ahead of print]


Wingless/Wnt Signaling in Intestinal Development, Homeostasis, Regeneration and Tumorigenesis: A Drosophila Perspective.

Tian A, Benchabane H, Ahmed Y.

J Dev Biol. 2018 Mar 28;6(2). pii: E8. doi: 10.3390/jdb6020008. Review.


APC Inhibits Ligand-Independent Wnt Signaling by the Clathrin Endocytic Pathway.

Saito-Diaz K, Benchabane H, Tiwari A, Tian A, Li B, Thompson JJ, Hyde AS, Sawyer LM, Jodoin JN, Santos E, Lee LA, Coffey RJ, Beauchamp RD, Williams CS, Kenworthy AK, Robbins DJ, Ahmed Y, Lee E.

Dev Cell. 2018 Mar 12;44(5):566-581.e8. doi: 10.1016/j.devcel.2018.02.013.


Axin phosphorylation in both Wnt-off and Wnt-on states requires the tumor suppressor APC.

Tacchelly-Benites O, Wang Z, Yang E, Benchabane H, Tian A, Randall MP, Ahmed Y.

PLoS Genet. 2018 Feb 6;14(2):e1007178. doi: 10.1371/journal.pgen.1007178. eCollection 2018 Feb.


Intestinal stem cell overproliferation resulting from inactivation of the APC tumor suppressor requires the transcription cofactors Earthbound and Erect wing.

Tian A, Benchabane H, Wang Z, Zimmerman C, Xin N, Perochon J, Kalna G, Sansom OJ, Cheng C, Cordero JB, Ahmed Y.

PLoS Genet. 2017 Jul 14;13(7):e1006870. doi: 10.1371/journal.pgen.1006870. eCollection 2017 Jul.


Comparative genetic screens in human cells reveal new regulatory mechanisms in WNT signaling.

Lebensohn AM, Dubey R, Neitzel LR, Tacchelly-Benites O, Yang E, Marceau CD, Davis EM, Patel BB, Bahrami-Nejad Z, Travaglini KJ, Ahmed Y, Lee E, Carette JE, Rohatgi R.

Elife. 2016 Dec 20;5. pii: e21459. doi: 10.7554/eLife.21459.


Dual Roles for Membrane Association of Drosophila Axin in Wnt Signaling.

Wang Z, Tacchelly-Benites O, Yang E, Ahmed Y.

PLoS Genet. 2016 Dec 13;12(12):e1006494. doi: 10.1371/journal.pgen.1006494. eCollection 2016 Dec.


The ADP-ribose polymerase Tankyrase regulates adult intestinal stem cell proliferation during homeostasis in Drosophila.

Wang Z, Tian A, Benchabane H, Tacchelly-Benites O, Yang E, Nojima H, Ahmed Y.

Development. 2016 May 15;143(10):1710-20. doi: 10.1242/dev.127647.


Wnt pathway activation by ADP-ribosylation.

Yang E, Tacchelly-Benites O, Wang Z, Randall MP, Tian A, Benchabane H, Freemantle S, Pikielny C, Tolwinski NS, Lee E, Ahmed Y.

Nat Commun. 2016 May 3;7:11430. doi: 10.1038/ncomms11430.


Wnt/Wingless Pathway Activation Is Promoted by a Critical Threshold of Axin Maintained by the Tumor Suppressor APC and the ADP-Ribose Polymerase Tankyrase.

Wang Z, Tacchelly-Benites O, Yang E, Thorne CA, Nojima H, Lee E, Ahmed Y.

Genetics. 2016 May;203(1):269-81. doi: 10.1534/genetics.115.183244. Epub 2016 Mar 14.


Regulation of Stem Cell Proliferation and Cell Fate Specification by Wingless/Wnt Signaling Gradients Enriched at Adult Intestinal Compartment Boundaries.

Tian A, Benchabane H, Wang Z, Ahmed Y.

PLoS Genet. 2016 Feb 4;12(2):e1005822. doi: 10.1371/journal.pgen.1005822. eCollection 2016 Feb.


Toggling a conformational switch in Wnt/β-catenin signaling: regulation of Axin phosphorylation. The phosphorylation state of Axin controls its scaffold function in two Wnt pathway protein complexes.

Tacchelly-Benites O, Wang Z, Yang E, Lee E, Ahmed Y.

Bioessays. 2013 Dec;35(12):1063-70. doi: 10.1002/bies.201300101. Epub 2013 Sep 19. Review.


Evidence for tankyrases as antineoplastic targets in lung cancer.

Busch AM, Johnson KC, Stan RV, Sanglikar A, Ahmed Y, Dmitrovsky E, Freemantle SJ.

BMC Cancer. 2013 Apr 28;13:211. doi: 10.1186/1471-2407-13-211.


Erect Wing facilitates context-dependent Wnt/Wingless signaling by recruiting the cell-specific Armadillo-TCF adaptor Earthbound to chromatin.

Xin N, Benchabane H, Tian A, Nguyen K, Klofas L, Ahmed Y.

Development. 2011 Nov;138(22):4955-67. doi: 10.1242/dev.068890.


Jerky/Earthbound facilitates cell-specific Wnt/Wingless signalling by modulating β-catenin-TCF activity.

Benchabane H, Xin N, Tian A, Hafler BP, Nguyen K, Ahmed A, Ahmed Y.

EMBO J. 2011 Apr 20;30(8):1444-58. doi: 10.1038/emboj.2011.67. Epub 2011 Mar 11.


Dual positive and negative regulation of wingless signaling by adenomatous polyposis coli.

Takacs CM, Baird JR, Hughes EG, Kent SS, Benchabane H, Paik R, Ahmed Y.

Science. 2008 Jan 18;319(5861):333-6. doi: 10.1126/science.1151232.


Drosophila Apc1 and Apc2 regulate Wingless transduction throughout development.

Ahmed Y, Nouri A, Wieschaus E.

Development. 2002 Apr;129(7):1751-62.


Regulation of armadillo by a Drosophila APC inhibits neuronal apoptosis during retinal development.

Ahmed Y, Hayashi S, Levine A, Wieschaus E.

Cell. 1998 Jun 26;93(7):1171-82.

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