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Oncoimmunology. 2015 Mar 19;4(7):e1005523. eCollection 2015 Jul.

Retrieval of functional TCRs from single antigen-specific T cells: Toward individualized TCR-engineered therapies.

Author information

1
TRON - Translational Oncology at the University Medical Center of Johannes Gutenberg University ; Mainz, Germany ; BioNTech Cell & Gene Therapies GmbH ; Mainz, Germany.
2
TRON - Translational Oncology at the University Medical Center of Johannes Gutenberg University ; Mainz, Germany.
3
TRON - Translational Oncology at the University Medical Center of Johannes Gutenberg University ; Mainz, Germany ; BioNTech Cell & Gene Therapies GmbH ; Mainz, Germany ; Research Center for Immunotherapy (FZI) at the University Medical Hospital; Johannes Gutenberg-University ; Mainz, Germany.

Abstract

We have developed a highly versatile platform for the systematic retrieval of T-cell receptors (TCRs) from single-antigen-reactive T cells and for characterization of their function and specificity. This approach enables rapid extraction of multiple TCRs from repertoires in individuals and not only broadens the diversity of TCRs suitable for clinical use, but also sets the stage for actively personalized immunotherapeutic strategies.

KEYWORDS:

adoptive cell transfer; T cell engineering; T cell receptor; epitope; personalized immunotherapy

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