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Page 1
The pathobiology of splicing.
Ward AJ, Cooper TA. Ward AJ, et al. J Pathol. 2010 Jan;220(2):152-63. doi: 10.1002/path.2649. J Pathol. 2010. PMID: 19918805 Free PMC article. Review.
Regulatory elements located within introns and exons guide the splicing complex, the spliceosome, and auxiliary RNA binding proteins to the correct sites for intron removal and exon joining. ...
Regulatory elements located within introns and exons guide the splicing complex, the spliceosome, and auxiliary RNA binding proteins …
Prolonged Posttreatment Virologic Control and Complete Seroreversion After Advanced Human Immunodeficiency Virus-1 Infection.
Uruena A, Cassetti I, Kashyap N, Deleage C, Estes JD, Trindade C, Hammoud DA, Burbelo PD, Natarajan V, Dewar R, Imamichi H, Ward AJ, Poole A, Ober A, Rehm C, Jones S, Liang CJ, Chun TW, Nath A, Lane HC, Smith BR, Connors M, Migueles SA. Uruena A, et al. Among authors: ward aj. Open Forum Infect Dis. 2020 Dec 15;8(1):ofaa613. doi: 10.1093/ofid/ofaa613. eCollection 2021 Jan. Open Forum Infect Dis. 2020. PMID: 33511235 Free PMC article.
RESULTS: No HIV-specific antibodies were detected in serum. Plasma HIV ribonucleic acid (RNA) levels were <0.2 copies/mL, and, except for low-frequency HIV deoxyribonucleic acid (DNA)(+) cells in lymph node tissue (1 copy/3 10(6) cells), HIV antigen could not be detecte …
RESULTS: No HIV-specific antibodies were detected in serum. Plasma HIV ribonucleic acid (RNA) levels were <0.2 copies/mL, and, exc …
Nonsense-mediated decay as a terminating mechanism for antisense oligonucleotides.
Ward AJ, Norrbom M, Chun S, Bennett CF, Rigo F. Ward AJ, et al. Nucleic Acids Res. 2014 May;42(9):5871-9. doi: 10.1093/nar/gku184. Epub 2014 Mar 3. Nucleic Acids Res. 2014. PMID: 24589581 Free PMC article.
Antisense oligonucleotides (ASOs) are synthetic oligonucleotides that alter expression of disease-associated transcripts via Watson-Crick hybridization. ASOs that function through RNase H or the RNA-induced silencing complex (RISC) result in enzymatic degradation of target …
Antisense oligonucleotides (ASOs) are synthetic oligonucleotides that alter expression of disease-associated transcripts via Watson-Crick hy …
Antagonistic regulation of mRNA expression and splicing by CELF and MBNL proteins.
Wang ET, Ward AJ, Cherone JM, Giudice J, Wang TT, Treacy DJ, Lambert NJ, Freese P, Saxena T, Cooper TA, Burge CB. Wang ET, et al. Among authors: ward aj. Genome Res. 2015 Jun;25(6):858-71. doi: 10.1101/gr.184390.114. Epub 2015 Apr 16. Genome Res. 2015. PMID: 25883322 Free PMC article.
RNA binding proteins of the conserved CUGBP1, Elav-like factor (CELF) family contribute to heart and skeletal muscle development and are implicated in myotonic dystrophy (DM). ...The extent of 3' UTR binding by CELF1 and MBNL1 predicted the degree of mRNA repression or sta …
RNA binding proteins of the conserved CUGBP1, Elav-like factor (CELF) family contribute to heart and skeletal muscle development and …
Antigenic Restimulation of Virus-Specific Memory CD8+ T Cells Requires Days of Lytic Protein Accumulation for Maximal Cytotoxic Capacity.
Migueles SA, Rogan DC, Gavil NV, Kelly EP, Toulmin SA, Wang LT, Lack J, Ward AJ, Pryal PF, Ludwig AK, Medina RG, Apple BJ, Toumanios CN, Poole AL, Rehm CA, Jones SE, Liang CJ, Connors M. Migueles SA, et al. Among authors: ward aj. J Virol. 2020 Nov 9;94(23):e01595-20. doi: 10.1128/JVI.01595-20. Print 2020 Nov 9. J Virol. 2020. PMID: 32907983 Free PMC article.
Imprinted Maternally Expressed microRNAs Antagonize Paternally Driven Gene Programs in Neurons.
Whipple AJ, Breton-Provencher V, Jacobs HN, Chitta UK, Sur M, Sharp PA. Whipple AJ, et al. Mol Cell. 2020 Apr 2;78(1):85-95.e8. doi: 10.1016/j.molcel.2020.01.020. Epub 2020 Feb 6. Mol Cell. 2020. PMID: 32032531 Free PMC article.
Using an induced neuron (iN) culture system, we show that maternally expressed miRNAs from the miR-379/410 cluster direct the RNA-induced silencing complex (RISC) to transcriptional and developmental regulators, including paternally expressed transcripts like Plagl1. ...
Using an induced neuron (iN) culture system, we show that maternally expressed miRNAs from the miR-379/410 cluster direct the RNA-ind …
Alternative splicing regulates vesicular trafficking genes in cardiomyocytes during postnatal heart development.
Giudice J, Xia Z, Wang ET, Scavuzzo MA, Ward AJ, Kalsotra A, Wang W, Wehrens XH, Burge CB, Li W, Cooper TA. Giudice J, et al. Among authors: ward aj. Nat Commun. 2014 Apr 22;5:3603. doi: 10.1038/ncomms4603. Nat Commun. 2014. PMID: 24752171 Free PMC article.
During postnatal development the heart undergoes a rapid and dramatic transition to adult function through transcriptional and post-transcriptional mechanisms, including alternative splicing (AS). Here we perform deep RNA-sequencing on RNA from cardiomyocytes and ca …
During postnatal development the heart undergoes a rapid and dramatic transition to adult function through transcriptional and post-transcri …
Alternative splicing dysregulation secondary to skeletal muscle regeneration.
Orengo JP, Ward AJ, Cooper TA. Orengo JP, et al. Among authors: ward aj. Ann Neurol. 2011 Apr;69(4):681-90. doi: 10.1002/ana.22278. Epub 2011 Mar 11. Ann Neurol. 2011. PMID: 21400563 Free PMC article.
OBJECTIVE: Dysregulation of alternative splicing has become a molecular hallmark of myotonic dystrophy type 1 (DM1), in which neonatal splice variants are expressed in adult skeletal muscle. Splicing dysregulation is induced by RNA containing expanded CUG repeats expressed …
OBJECTIVE: Dysregulation of alternative splicing has become a molecular hallmark of myotonic dystrophy type 1 (DM1), in which neonatal splic …
Lost in Translation: Lack of CD4 Expression due to a Novel Genetic Defect.
Lisco A, Ye P, Wong CS, Pei L, Hsu AP, Mace EM, Orange JS, Lage SL, Ward AJ, Migueles SA, Connors M, Anderson MV, Buckner CM, Moir S, Rupert A, Dulau-Florea A, Ogbogu P, Timberlake D, Notarangelo LD, Pittaluga S, Abraham RS, Sereti I. Lisco A, et al. Among authors: ward aj. J Infect Dis. 2021 Feb 24;223(4):645-654. doi: 10.1093/infdis/jiab025. J Infect Dis. 2021. PMID: 33471124 Free PMC article.
Towards a therapy for Angelman syndrome by targeting a long non-coding RNA.
Meng L, Ward AJ, Chun S, Bennett CF, Beaudet AL, Rigo F. Meng L, et al. Among authors: ward aj. Nature. 2015 Feb 19;518(7539):409-12. doi: 10.1038/nature13975. Epub 2014 Dec 1. Nature. 2015. PMID: 25470045 Free PMC article.
All patients carry at least one copy of paternal UBE3A, which is intact but silenced by a nuclear-localized long non-coding RNA, UBE3A antisense transcript (UBE3A-ATS). Murine Ube3a-ATS reduction by either transcription termination or topoisomerase I inhibition has been sh …
All patients carry at least one copy of paternal UBE3A, which is intact but silenced by a nuclear-localized long non-coding RNA, UBE3 …
16 results