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Items: 1 to 20 of 92

1.

Pak1 Kinase Promotes Activated T Cell Trafficking by Regulating the Expression of L-Selectin and CCR7.

Dios-Esponera A, Melis N, Subramanian BC, Weigert R, Samelson LE.

Front Immunol. 2019 Mar 5;10:370. doi: 10.3389/fimmu.2019.00370. eCollection 2019.

2.

TCR microclusters form spatially segregated domains and sequentially assemble in calcium-dependent kinetic steps.

Yi J, Balagopalan L, Nguyen T, McIntire KM, Samelson LE.

Nat Commun. 2019 Jan 17;10(1):277. doi: 10.1038/s41467-018-08064-2.

3.

Plasma membrane LAT activation precedes vesicular recruitment defining two phases of early T-cell activation.

Balagopalan L, Yi J, Nguyen T, McIntire KM, Harned AS, Narayan K, Samelson LE.

Nat Commun. 2018 May 22;9(1):2013. doi: 10.1038/s41467-018-04419-x.

4.

The Cish SH2 domain is essential for PLC-γ1 regulation in TCR stimulated CD8+ T cells.

Guittard G, Dios-Esponera A, Palmer DC, Akpan I, Barr VA, Manna A, Restifo NP, Samelson LE.

Sci Rep. 2018 Mar 28;8(1):5336. doi: 10.1038/s41598-018-23549-2.

5.

Intensity and duration of TCR signaling is limited by p38 phosphorylation of ZAP-70T293 and destabilization of the signalosome.

Giardino Torchia ML, Dutta D, Mittelstadt PR, Guha J, Gaida MM, Fish K, Barr VA, Akpan IO, Samelson LE, Tagad HD, Debnath S, Miller Jenkins LM, Appella E, Ashwell JD.

Proc Natl Acad Sci U S A. 2018 Feb 27;115(9):2174-2179. doi: 10.1073/pnas.1713301115. Epub 2018 Feb 12.

6.

Highly Multiplexed, Super-resolution Imaging of T Cells Using madSTORM.

Yi J, Manna A, Barr VA, Hong J, Neuman KC, Samelson LE.

J Vis Exp. 2017 Jun 24;(124). doi: 10.3791/55997.

7.

Recruitment of calcineurin to the TCR positively regulates T cell activation.

Dutta D, Barr VA, Akpan I, Mittelstadt PR, Singha LI, Samelson LE, Ashwell JD.

Nat Immunol. 2017 Feb;18(2):196-204. doi: 10.1038/ni.3640. Epub 2016 Dec 12.

8.

madSTORM: a superresolution technique for large-scale multiplexing at single-molecule accuracy.

Yi J, Manna A, Barr VA, Hong J, Neuman KC, Samelson LE.

Mol Biol Cell. 2016 Nov 7;27(22):3591-3600. Epub 2016 Oct 5.

9.

The linker for activation of T cells (LAT) signaling hub: from signaling complexes to microclusters.

Balagopalan L, Kortum RL, Coussens NP, Barr VA, Samelson LE.

J Biol Chem. 2015 Oct 30;290(44):26422-9. doi: 10.1074/jbc.R115.665869. Epub 2015 Sep 9. Review.

10.

miR-155 Controls Lymphoproliferation in LAT Mutant Mice by Restraining T-Cell Apoptosis via SHIP-1/mTOR and PAK1/FOXO3/BIM Pathways.

Rouquette-Jazdanian AK, Kortum RL, Li W, Merrill RK, Nguyen PH, Samelson LE, Sommers CL.

PLoS One. 2015 Jun 29;10(6):e0131823. doi: 10.1371/journal.pone.0131823. eCollection 2015.

11.

Enhanced T-cell activation and differentiation in lymphocytes from transgenic mice expressing ubiquitination-resistant 2KR LAT molecules.

Rodriguez-Peña AB, Gomez-Rodriguez J, Kortum RL, Palmer DC, Yu Z, Guittard GC, Wohlfert EA, Silver PB, Misplon JA, Sommers CL, Feigenbaum L, Epstein SL, Caspi RR, Belkaid Y, Restifo NP, Samelson LE, Balagopalan L.

Gene Ther. 2015 Oct;22(10):781-92. doi: 10.1038/gt.2015.48. Epub 2015 Jun 18.

12.

Cytoskeletal forces during signaling activation in Jurkat T-cells.

Hui KL, Balagopalan L, Samelson LE, Upadhyaya A.

Mol Biol Cell. 2015 Feb 15;26(4):685-95. doi: 10.1091/mbc.E14-03-0830. Epub 2014 Dec 17.

13.

In vivo functional mapping of the conserved protein domains within murine Themis1.

Zvezdova E, Lee J, El-Khoury D, Barr V, Akpan I, Samelson L, Love PE.

Immunol Cell Biol. 2014 Sep;92(8):721-8. doi: 10.1038/icb.2014.43. Epub 2014 Jun 17.

14.

The ability of Sos1 to oligomerize the adaptor protein LAT is separable from its guanine nucleotide exchange activity in vivo.

Kortum RL, Balagopalan L, Alexander CP, Garcia J, Pinski JM, Merrill RK, Nguyen PH, Li W, Agarwal I, Akpan IO, Sommers CL, Samelson LE.

Sci Signal. 2013 Nov 12;6(301):ra99. doi: 10.1126/scisignal.2004494.

15.

miRNA signature of mouse helper T cell hyper-proliferation.

Sommers CL, Rouquette-Jazdanian AK, Robles AI, Kortum RL, Merrill RK, Li W, Nath N, Wohlfert E, Sixt KM, Belkaid Y, Samelson LE.

PLoS One. 2013 Jun 25;8(6):e66709. doi: 10.1371/journal.pone.0066709. Print 2013.

16.

Ras and extracellular signal-regulated kinase signaling in thymocytes and T cells.

Kortum RL, Rouquette-Jazdanian AK, Samelson LE.

Trends Immunol. 2013 Jun;34(6):259-68. doi: 10.1016/j.it.2013.02.004. Epub 2013 Mar 15. Review.

17.

Cutting edge: cell surface linker for activation of T cells is recruited to microclusters and is active in signaling.

Balagopalan L, Barr VA, Kortum RL, Park AK, Samelson LE.

J Immunol. 2013 Apr 15;190(8):3849-53. doi: 10.4049/jimmunol.1202760. Epub 2013 Mar 13.

18.

A phospholipase C-γ1-independent, RasGRP1-ERK-dependent pathway drives lymphoproliferative disease in linker for activation of T cells-Y136F mutant mice.

Kortum RL, Rouquette-Jazdanian AK, Miyaji M, Merrill RK, Markegard E, Pinski JM, Wesselink A, Nath NN, Alexander CP, Li W, Kedei N, Roose JP, Blumberg PM, Samelson LE, Sommers CL.

J Immunol. 2013 Jan 1;190(1):147-58. doi: 10.4049/jimmunol.1201458. Epub 2012 Dec 3.

19.

LAT-independent Erk activation via Bam32-PLC-γ1-Pak1 complexes: GTPase-independent Pak1 activation.

Rouquette-Jazdanian AK, Sommers CL, Kortum RL, Morrison DK, Samelson LE.

Mol Cell. 2012 Oct 26;48(2):298-312. doi: 10.1016/j.molcel.2012.08.011. Epub 2012 Sep 13.

20.

Interchangeability of Themis1 and Themis2 in thymocyte development reveals two related proteins with conserved molecular function.

Lesourne R, Zvezdova E, Song KD, El-Khoury D, Uehara S, Barr VA, Samelson LE, Love PE.

J Immunol. 2012 Aug 1;189(3):1154-61. doi: 10.4049/jimmunol.1200123. Epub 2012 Jun 25.

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