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Items: 1 to 20 of 67


Striatal Mutant Huntingtin Protein Levels Decline with Age in Homozygous Huntington's Disease Knock-In Mouse Models.

Franich NR, Basso M, André EA, Ochaba J, Kumar A, Thein S, Fote G, Kachemov M, Lau AL, Yeung SY, Osmand A, Zeitlin SO, Ratan RR, Thompson LM, Steffan JS.

J Huntingtons Dis. 2018;7(2):137-150. doi: 10.3233/JHD-170274.


Activation of Nrf2 and Hypoxic Adaptive Response Contribute to Neuroprotection Elicited by Phenylhydroxamic Acid Selective HDAC6 Inhibitors.

Gaisina IN, Lee SH, Kaidery NA, Ben Aissa M, Ahuja M, Smirnova NN, Wakade S, Gaisin A, Bourassa MW, Ratan RR, Nikulin SV, Poloznikov AA, Thomas B, Thatcher GRJ, Gazaryan IG.

ACS Chem Neurosci. 2018 May 16;9(5):894-900. doi: 10.1021/acschemneuro.7b00435. Epub 2018 Jan 17.


Designing Dual Transglutaminase 2/Histone Deacetylase Inhibitors Effective at Halting Neuronal Death.

Basso M, Chen HH, Tripathy D, Conte M, Apperley KYP, De Simone A, Keillor JW, Ratan R, Nebbioso A, Sarno F, Altucci L, Milelli A.

ChemMedChem. 2018 Feb 6;13(3):227-230. doi: 10.1002/cmdc.201700601. Epub 2018 Jan 18.


Rehabilitation following hemorrhagic stroke: building the case for stroke-subtype specific recovery therapies.

Kitago T, Ratan RR.

F1000Res. 2017 Nov 23;6:2044. doi: 10.12688/f1000research.11913.1. eCollection 2017. Review.


Building on NeuroNEXT: Next generation clinics to cure chronic neurological disability.

Ratan RR.

Ann Neurol. 2017 Dec;82(6):859-862. doi: 10.1002/ana.25108. Epub 2017 Dec 8. No abstract available.


Neuronal Death After Hemorrhagic Stroke In Vitro and In Vivo Shares Features of Ferroptosis and Necroptosis.

Zille M, Karuppagounder SS, Chen Y, Gough PJ, Bertin J, Finger J, Milner TA, Jonas EA, Ratan RR.

Stroke. 2017 Apr;48(4):1033-1043. doi: 10.1161/STROKEAHA.116.015609. Epub 2017 Mar 1.


Oxidative Stress and Huntington's Disease: The Good, The Bad, and The Ugly.

Kumar A, Ratan RR.

J Huntingtons Dis. 2016 Oct 1;5(3):217-237. Review.


Hypoxic Adaptation in the Nervous System: Promise for Novel Therapeutics for Acute and Chronic Neurodegeneration.

Speer R, Ratan RR.

Adv Exp Med Biol. 2016;903:221-43. doi: 10.1007/978-1-4899-7678-9_16. Review.


Nature and nurture meet at the epigenome to modulate disorders of the nervous system.

Cave JW, Langley B, Ratan RR.

Neurosci Lett. 2016 Jun 20;625:1-3. doi: 10.1016/j.neulet.2016.05.052. No abstract available.


Distinct Nrf2 Signaling Mechanisms of Fumaric Acid Esters and Their Role in Neuroprotection against 1-Methyl-4-Phenyl-1,2,3,6-Tetrahydropyridine-Induced Experimental Parkinson's-Like Disease.

Ahuja M, Ammal Kaidery N, Yang L, Calingasan N, Smirnova N, Gaisin A, Gaisina IN, Gazaryan I, Hushpulian DM, Kaddour-Djebbar I, Bollag WB, Morgan JC, Ratan RR, Starkov AA, Beal MF, Thomas B.

J Neurosci. 2016 Jun 8;36(23):6332-51. doi: 10.1523/JNEUROSCI.0426-16.2016.


Exercise promotes the expression of brain derived neurotrophic factor (BDNF) through the action of the ketone body β-hydroxybutyrate.

Sleiman SF, Henry J, Al-Haddad R, El Hayek L, Abou Haidar E, Stringer T, Ulja D, Karuppagounder SS, Holson EB, Ratan RR, Ninan I, Chao MV.

Elife. 2016 Jun 2;5. pii: e15092. doi: 10.7554/eLife.15092.


Inhibition of HIF-prolyl-4-hydroxylases prevents mitochondrial impairment and cell death in a model of neuronal oxytosis.

Neitemeier S, Dolga AM, Honrath B, Karuppagounder SS, Alim I, Ratan RR, Culmsee C.

Cell Death Dis. 2016 May 5;7:e2214. doi: 10.1038/cddis.2016.107.


Therapeutic targeting of oxygen-sensing prolyl hydroxylases abrogates ATF4-dependent neuronal death and improves outcomes after brain hemorrhage in several rodent models.

Karuppagounder SS, Alim I, Khim SJ, Bourassa MW, Sleiman SF, John R, Thinnes CC, Yeh TL, Demetriades M, Neitemeier S, Cruz D, Gazaryan I, Killilea DW, Morgenstern L, Xi G, Keep RF, Schallert T, Tappero RV, Zhong J, Cho S, Maxfield FR, Holman TR, Culmsee C, Fong GH, Su Y, Ming GL, Song H, Cave JW, Schofield CJ, Colbourne F, Coppola G, Ratan RR.

Sci Transl Med. 2016 Mar 2;8(328):328ra29. doi: 10.1126/scitranslmed.aac6008.


Butyrate, neuroepigenetics and the gut microbiome: Can a high fiber diet improve brain health?

Bourassa MW, Alim I, Bultman SJ, Ratan RR.

Neurosci Lett. 2016 Jun 20;625:56-63. doi: 10.1016/j.neulet.2016.02.009. Epub 2016 Feb 8. Review.


Daidzein Augments Cholesterol Homeostasis via ApoE to Promote Functional Recovery in Chronic Stroke.

Kim E, Woo MS, Qin L, Ma T, Beltran CD, Bao Y, Bailey JA, Corbett D, Ratan RR, Lahiri DK, Cho S.

J Neurosci. 2015 Nov 11;35(45):15113-26. doi: 10.1523/JNEUROSCI.2890-15.2015.


Metabolism and epigenetics in the nervous system: Creating cellular fitness and resistance to neuronal death in neurological conditions via modulation of oxygen-, iron-, and 2-oxoglutarate-dependent dioxygenases.

Karuppagounder SS, Kumar A, Shao DS, Zille M, Bourassa MW, Caulfield JT, Alim I, Ratan RR.

Brain Res. 2015 Dec 2;1628(Pt B):273-287. doi: 10.1016/j.brainres.2015.07.030. Epub 2015 Jul 29. Review.


Hydroxamate-based histone deacetylase inhibitors can protect neurons from oxidative stress via a histone deacetylase-independent catalase-like mechanism.

Olson DE, Sleiman SF, Bourassa MW, Wagner FF, Gale JP, Zhang YL, Ratan RR, Holson EB.

Chem Biol. 2015 Apr 23;22(4):439-445. doi: 10.1016/j.chembiol.2015.03.014. Epub 2015 Apr 16.


Spatial, temporal, and quantitative manipulation of intracellular hydrogen peroxide in cultured cells.

Alim I, Haskew-Layton RE, Aleyasin H, Guo H, Ratan RR.

Methods Enzymol. 2014;547:251-73. doi: 10.1016/B978-0-12-801415-8.00014-X.


Recent advances in hydrogen peroxide imaging for biological applications.

Guo H, Aleyasin H, Dickinson BC, Haskew-Layton RE, Ratan RR.

Cell Biosci. 2014 Oct 27;4(1):64. doi: 10.1186/2045-3701-4-64. eCollection 2014. Review.


Hydroxamic acid-based histone deacetylase (HDAC) inhibitors can mediate neuroprotection independent of HDAC inhibition.

Sleiman SF, Olson DE, Bourassa MW, Karuppagounder SS, Zhang YL, Gale J, Wagner FF, Basso M, Coppola G, Pinto JT, Holson EB, Ratan RR.

J Neurosci. 2014 Oct 22;34(43):14328-37. doi: 10.1523/JNEUROSCI.1010-14.2014. Erratum in: J Neurosci. 2015 Jan 7;35(1):438.

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