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Items: 19


Structure and mechanism of human PrimPol, a DNA polymerase with primase activity.

Rechkoblit O, Gupta YK, Malik R, Rajashankar KR, Johnson RE, Prakash L, Prakash S, Aggarwal AK.

Sci Adv. 2016 Oct 21;2(10):e1601317. eCollection 2016 Oct.


A Small Molecule RAS-Mimetic Disrupts RAS Association with Effector Proteins to Block Signaling.

Athuluri-Divakar SK, Vasquez-Del Carpio R, Dutta K, Baker SJ, Cosenza SC, Basu I, Gupta YK, Reddy MV, Ueno L, Hart JR, Vogt PK, Mulholland D, Guha C, Aggarwal AK, Reddy EP.

Cell. 2016 Apr 21;165(3):643-55. doi: 10.1016/j.cell.2016.03.045.


Structure of Type IIL Restriction-Modification Enzyme MmeI in Complex with DNA Has Implications for Engineering New Specificities.

Callahan SJ, Luyten YA, Gupta YK, Wilson GG, Roberts RJ, Morgan RD, Aggarwal AK.

PLoS Biol. 2016 Apr 15;14(4):e1002442. doi: 10.1371/journal.pbio.1002442. eCollection 2016 Apr. Erratum in: PLoS Biol. 2016 May;14(5):e1002471.


Structural basis of asymmetric DNA methylation and ATP-triggered long-range diffusion by EcoP15I.

Gupta YK, Chan SH, Xu SY, Aggarwal AK.

Nat Commun. 2015 Jun 12;6:7363. doi: 10.1038/ncomms8363.


Expression and purification of a single-chain Type IV restriction enzyme Eco94GmrSD and determination of its substrate preference.

He X, Hull V, Thomas JA, Fu X, Gidwani S, Gupta YK, Black LW, Xu SY.

Sci Rep. 2015 May 19;5:9747. doi: 10.1038/srep09747.


An Inhibitor of PIDDosome Formation.

Thompson R, Shah RB, Liu PH, Gupta YK, Ando K, Aggarwal AK, Sidi S.

Mol Cell. 2015 Jun 4;58(5):767-79. doi: 10.1016/j.molcel.2015.03.034. Epub 2015 Apr 30.


Phosphatidylinositol 4,5-bisphosphate clusters the cell adhesion molecule CD44 and assembles a specific CD44-Ezrin heterocomplex, as revealed by small angle neutron scattering.

Chen X, Khajeh JA, Ju JH, Gupta YK, Stanley CB, Do C, Heller WT, Aggarwal AK, Callaway DJ, Bu Z.

J Biol Chem. 2015 Mar 6;290(10):6639-52. doi: 10.1074/jbc.M114.589523. Epub 2015 Jan 8.


Bisphosphonates inactivate human EGFRs to exert antitumor actions.

Yuen T, Stachnik A, Iqbal J, Sgobba M, Gupta Y, Lu P, Colaianni G, Ji Y, Zhu LL, Kim SM, Li J, Liu P, Izadmehr S, Sangodkar J, Bailey J, Latif Y, Mujtaba S, Epstein S, Davies TF, Bian Z, Zallone A, Aggarwal AK, Haider S, New MI, Sun L, Narla G, Zaidi M.

Proc Natl Acad Sci U S A. 2014 Dec 16;111(50):17989-94. doi: 10.1073/pnas.1421410111. Epub 2014 Dec 1.


Repurposing of bisphosphonates for the prevention and therapy of nonsmall cell lung and breast cancer.

Stachnik A, Yuen T, Iqbal J, Sgobba M, Gupta Y, Lu P, Colaianni G, Ji Y, Zhu LL, Kim SM, Li J, Liu P, Izadmehr S, Sangodkar J, Scherer T, Mujtaba S, Galsky M, Gomez J, Epstein S, Buettner C, Bian Z, Zallone A, Aggarwal AK, Haider S, New MI, Sun L, Narla G, Zaidi M.

Proc Natl Acad Sci U S A. 2014 Dec 16;111(50):17995-8000. doi: 10.1073/pnas.1421422111. Epub 2014 Dec 1.


Anthrax SET protein: a potential virulence determinant that epigenetically represses NF-κB activation in infected macrophages.

Mujtaba S, Winer BY, Jaganathan A, Patel J, Sgobba M, Schuch R, Gupta YK, Haider S, Wang R, Fischetti VA.

J Biol Chem. 2013 Aug 9;288(32):23458-72. doi: 10.1074/jbc.M113.467696. Epub 2013 May 29.


Natural zinc ribbon HNH endonucleases and engineered zinc finger nicking endonuclease.

Xu SY, Gupta YK.

Nucleic Acids Res. 2013 Jan 7;41(1):378-90. doi: 10.1093/nar/gks1043. Epub 2012 Nov 3.


Structural insights into the assembly and shape of Type III restriction-modification (R-M) EcoP15I complex by small-angle X-ray scattering.

Gupta YK, Yang L, Chan SH, Samuelson JC, Xu SY, Aggarwal AK.

J Mol Biol. 2012 Jul 20;420(4-5):261-8. doi: 10.1016/j.jmb.2012.04.026. Epub 2012 May 2.


Characterization of type II and III restriction-modification systems from Bacillus cereus strains ATCC 10987 and ATCC 14579.

Xu SY, Nugent RL, Kasamkattil J, Fomenkov A, Gupta Y, Aggarwal A, Wang X, Li Z, Zheng Y, Morgan R.

J Bacteriol. 2012 Jan;194(1):49-60. doi: 10.1128/JB.06248-11. Epub 2011 Oct 28.


Co-occupancy of two Pumilio molecules on a single hunchback NRE.

Gupta YK, Lee TH, Edwards TA, Escalante CR, Kadyrova LY, Wharton RP, Aggarwal AK.

RNA. 2009 Jun;15(6):1029-35. doi: 10.1261/rna.1327609. Epub 2009 Apr 16.


Structures of human Pumilio with noncognate RNAs reveal molecular mechanisms for binding promiscuity.

Gupta YK, Nair DT, Wharton RP, Aggarwal AK.

Structure. 2008 Apr;16(4):549-57. doi: 10.1016/j.str.2008.01.006. Epub 2008 Mar 6.


Paramagnetism-based NMR restraints provide maximum allowed probabilities for the different conformations of partially independent protein domains.

Bertini I, Gupta YK, Luchinat C, Parigi G, Peana M, Sgheri L, Yuan J.

J Am Chem Soc. 2007 Oct 24;129(42):12786-94. Epub 2007 Oct 2.


Solution structure of the Vts1 SAM domain in the presence of RNA.

Edwards TA, Butterwick JA, Zeng L, Gupta YK, Wang X, Wharton RP, Palmer AG 3rd, Aggarwal AK.

J Mol Biol. 2006 Mar 10;356(5):1065-72. Epub 2005 Dec 20.


NMR spectroscopic detection of protein protons and longitudinal relaxation rates between 0.01 and 50 MHz.

Bertini I, Gupta YK, Luchinat C, Parigi G, Schlörb C, Schwalbe H.

Angew Chem Int Ed Engl. 2005 Apr 8;44(15):2223-5. No abstract available.


Paramagnetism-based refinement strategy for the solution structure of human alpha-parvalbumin.

Baig I, Bertini I, Del Bianco C, Gupta YK, Lee YM, Luchinat C, Quattrone A.

Biochemistry. 2004 May 11;43(18):5562-73.


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