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Cell. 2016 Aug 25;166(5):1080-1081. doi: 10.1016/j.cell.2016.08.014.

Tag Team Ubiquitin Ligases.

Author information

1
Department of Chemistry and Biochemistry, University of Nevada, Las Vegas, 4505 South Maryland Parkway, Las Vegas, NV 89154, USA.
2
Division of Biology and Biological Engineering, California Institute of Technology, 1200 East California Blvd, Pasadena, CA 91125, USA; Howard Hughes Medical Institute. Electronic address: deshaies@caltech.edu.

Abstract

Cullin-RING (CRL) and RING1-IBR-RING2 (RBR) are two distinct types of ubiquitin ligases. In this issue, Scott et al. show that CRLs activate the RBR enzyme ARIH1 to initiate ubiquitin chains on CRL substrates, thereby marking an unexpected and important advance in our understanding of both enzymes.

PMID:
27565338
DOI:
10.1016/j.cell.2016.08.014
[Indexed for MEDLINE]
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