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Exp Cell Res. 2011 Nov 15;317(19):2702-10. doi: 10.1016/j.yexcr.2011.09.006. Epub 2011 Sep 24.

Intestinal development and differentiation.

Author information

1
Division of Gastroenterology, Hepatology and Nutrition, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.

Abstract

In this review, we present an overview of intestinal development and cellular differentiation of the intestinal epithelium. The review is separated into two sections: Section one summarizes organogenesis of the small and large intestines, including endoderm and gut tube formation in early embryogenesis, villus morphogenesis, and crypt formation. Section two reviews cell fate specification and differentiation of each cell type within the intestinal epithelium. Growth factor and transcriptional networks that regulate these developmental processes are summarized.

PMID:
21978911
PMCID:
PMC3210330
DOI:
10.1016/j.yexcr.2011.09.006
[Indexed for MEDLINE]
Free PMC Article

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