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The mitochondrial-targeted peptide, SS-31, improves glomerular architecture in mice of advanced age.

Sweetwyne MT, Pippin JW, Eng DG, Hudkins KL, Chiao YA, Campbell MD, Marcinek DJ, Alpers CE, Szeto HH, Rabinovitch PS, Shankland SJ.

Kidney Int. 2017 Jan 4. pii: S0085-2538(16)30652-4. doi: 10.1016/j.kint.2016.10.036. [Epub ahead of print]


Mitochondrial-targeted catalase is good for the old mouse proteome, but not for the young: 'reverse' antagonistic pleiotropy?

Basisty N, Dai DF, Gagnidze A, Gitari L, Fredrickson J, Maina Y, Beyer RP, Emond MJ, Hsieh EJ, MacCoss MJ, Martin GM, Rabinovitch PS.

Aging Cell. 2016 Aug;15(4):634-45. doi: 10.1111/acel.12472.


Rapamycin transiently induces mitochondrial remodeling to reprogram energy metabolism in old hearts.

Chiao YA, Kolwicz SC, Basisty N, Gagnidze A, Zhang J, Gu H, Djukovic D, Beyer RP, Raftery D, MacCoss M, Tian R, Rabinovitch PS.

Aging (Albany NY). 2016 Feb;8(2):314-27.


Healthy aging: The ultimate preventative medicine.

Kaeberlein M, Rabinovitch PS, Martin GM.

Science. 2015 Dec 4;350(6265):1191-3. doi: 10.1126/science.aad3267. Review.


AMPK is critical for mitochondrial function during reperfusion after myocardial ischemia.

Zaha VG, Qi D, Su KN, Palmeri M, Lee HY, Hu X, Wu X, Shulman GI, Rabinovitch PS, Russell RR 3rd, Young LH.

J Mol Cell Cardiol. 2016 Feb;91:104-13. doi: 10.1016/j.yjmcc.2015.12.032.


Age modifies respiratory complex I and protein homeostasis in a muscle type-specific manner.

Kruse SE, Karunadharma PP, Basisty N, Johnson R, Beyer RP, MacCoss MJ, Rabinovitch PS, Marcinek DJ.

Aging Cell. 2016 Feb;15(1):89-99. doi: 10.1111/acel.12412.


The Aging Heart.

Chiao YA, Rabinovitch PS.

Cold Spring Harb Perspect Med. 2015 Sep 1;5(9):a025148. doi: 10.1101/cshperspect.a025148. Review.


Dose-dependent effects of mTOR inhibition on weight and mitochondrial disease in mice.

Johnson SC, Yanos ME, Bitto A, Castanza A, Gagnidze A, Gonzalez B, Gupta K, Hui J, Jarvie C, Johnson BM, Letexier N, McCanta L, Sangesland M, Tamis O, Uhde L, Van Den Ende A, Rabinovitch PS, Suh Y, Kaeberlein M.

Front Genet. 2015 Jul 22;6:247. doi: 10.3389/fgene.2015.00247.


High Goblet Cell Count Is Inversely Associated with Ploidy Abnormalities and Risk of Adenocarcinoma in Barrett's Esophagus.

Srivastava A, Golden KL, Sanchez CA, Liu K, Fong PY, Li X, Cowan DS, Rabinovitch PS, Reid BJ, Blount PL, Odze RD.

PLoS One. 2015 Jul 31;10(7):e0133403. doi: 10.1371/journal.pone.0133403.


Mitochondrial dysfunction in cardiac aging.

Tocchi A, Quarles EK, Basisty N, Gitari L, Rabinovitch PS.

Biochim Biophys Acta. 2015 Nov;1847(11):1424-33. doi: 10.1016/j.bbabio.2015.07.009. Review.


Respiratory chain protein turnover rates in mice are highly heterogeneous but strikingly conserved across tissues, ages, and treatments.

Karunadharma PP, Basisty N, Chiao YA, Dai DF, Drake R, Levy N, Koh WJ, Emond MJ, Kruse S, Marcinek D, Maccoss MJ, Rabinovitch PS.

FASEB J. 2015 Aug;29(8):3582-92. doi: 10.1096/fj.15-272666.


Outcome of "indefinite for dysplasia" in inflammatory bowel disease: correlation with DNA flow cytometry and other risk factors of colorectal cancer.

Choi WT, Rabinovitch PS, Wang D, Westerhoff M.

Hum Pathol. 2015 Jul;46(7):939-47. doi: 10.1016/j.humpath.2015.03.009.


Subacute calorie restriction and rapamycin discordantly alter mouse liver proteome homeostasis and reverse aging effects.

Karunadharma PP, Basisty N, Dai DF, Chiao YA, Quarles EK, Hsieh EJ, Crispin D, Bielas JH, Ericson NG, Beyer RP, MacKay VL, MacCoss MJ, Rabinovitch PS.

Aging Cell. 2015 Aug;14(4):547-57. doi: 10.1111/acel.12317.


"Indefinite for Dysplasia" in Barrett's Esophagus: Inflammation and DNA Content Abnormality are Significant Predictors of Early Detection of Neoplasia.

Choi WT, Emond MJ, Rabinovitch PS, Ahn J, Upton MP, Westerhoff M.

Clin Transl Gastroenterol. 2015 Mar 12;6:e81. doi: 10.1038/ctg.2015.7.


Quality control systems in cardiac aging.

Quarles EK, Dai DF, Tocchi A, Basisty N, Gitari L, Rabinovitch PS.

Ageing Res Rev. 2015 Sep;23(Pt A):101-15. doi: 10.1016/j.arr.2015.02.003. Review.


Modulating mTOR in aging and health.

Johnson SC, Sangesland M, Kaeberlein M, Rabinovitch PS.

Interdiscip Top Gerontol. 2015;40:107-27. doi: 10.1159/000364974. Review.


MRE11-deficiency associated with improved long-term disease free survival and overall survival in a subset of stage III colon cancer patients in randomized CALGB 89803 trial.

Pavelitz T, Renfro L, Foster NR, Caracol A, Welsch P, Lao VV, Grady WB, Niedzwiecki D, Saltz LB, Bertagnolli MM, Goldberg RM, Rabinovitch PS, Emond M, Monnat RJ Jr, Maizels N.

PLoS One. 2014 Oct 13;9(10):e108483. doi: 10.1371/journal.pone.0108483.


Super-suppression of mitochondrial reactive oxygen species signaling impairs compensatory autophagy in primary mitophagic cardiomyopathy.

Song M, Chen Y, Gong G, Murphy E, Rabinovitch PS, Dorn GW 2nd.

Circ Res. 2014 Jul 18;115(3):348-53. doi: 10.1161/CIRCRESAHA.115.304384.


Mitochondrial oxidative stress in aging and healthspan.

Dai DF, Chiao YA, Marcinek DJ, Szeto HH, Rabinovitch PS.

Longev Healthspan. 2014 May 1;3:6. doi: 10.1186/2046-2395-3-6. Review.


The oxygen-rich postnatal environment induces cardiomyocyte cell-cycle arrest through DNA damage response.

Puente BN, Kimura W, Muralidhar SA, Moon J, Amatruda JF, Phelps KL, Grinsfelder D, Rothermel BA, Chen R, Garcia JA, Santos CX, Thet S, Mori E, Kinter MT, Rindler PM, Zacchigna S, Mukherjee S, Chen DJ, Mahmoud AI, Giacca M, Rabinovitch PS, Aroumougame A, Shah AM, Szweda LI, Sadek HA.

Cell. 2014 Apr 24;157(3):565-79. doi: 10.1016/j.cell.2014.03.032. Erratum in: Cell. 2014 May 22;157(5):1243.

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