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Utility of DNA Flow Cytometric Analysis of Paraffin-Embedded Tissue in the Risk Stratification and Management of "Indefinite for Dysplasia" in Patients with Inflammatory Bowel Disease.

Wen KW, Rabinovitch PS, Wang D, Huang D, Mattis AN, Choi WT.

J Crohns Colitis. 2018 Nov 13. doi: 10.1093/ecco-jcc/jjy193. [Epub ahead of print]


Identifying ubiquitinated proteins and aggregates.

Basisty N, Schilling B, Rabinovitch PS.

Aging (Albany NY). 2018 Oct 18;10(10):2549-2550. doi: 10.18632/aging.101605. No abstract available.


Heart specific knockout of Ndufs4 ameliorates ischemia reperfusion injury.

Zhang H, Gong G, Wang P, Zhang Z, Kolwicz SC, Rabinovitch PS, Tian R, Wang W.

J Mol Cell Cardiol. 2018 Oct;123:38-45. doi: 10.1016/j.yjmcc.2018.08.022. Epub 2018 Aug 27.


Use of DNA flow cytometry in the diagnosis, risk stratification, and management of gastric epithelial dysplasia.

Wen KW, Rabinovitch PS, Huang D, Mattis AN, Lauwers GY, Choi WT.

Mod Pathol. 2018 Oct;31(10):1578-1587. doi: 10.1038/s41379-018-0062-2. Epub 2018 May 22.


DNA content analysis of colorectal serrated lesions detects an aneuploid subset of inflammatory bowel disease-associated serrated epithelial change and traditional serrated adenomas.

Choi WT, Wen KW, Rabinovitch PS, Huang D, Mattis AN, Gill RM.

Histopathology. 2018 Sep;73(3):464-472. doi: 10.1111/his.13652. Epub 2018 Jun 28.


Treatment with the mitochondrial-targeted antioxidant peptide SS-31 rescues neurovascular coupling responses and cerebrovascular endothelial function and improves cognition in aged mice.

Tarantini S, Valcarcel-Ares NM, Yabluchanskiy A, Fulop GA, Hertelendy P, Gautam T, Farkas E, Perz A, Rabinovitch PS, Sonntag WE, Csiszar A, Ungvari Z.

Aging Cell. 2018 Apr;17(2). doi: 10.1111/acel.12731. Epub 2018 Feb 6.


Stable Isotope Labeling Reveals Novel Insights Into Ubiquitin-Mediated Protein Aggregation With Age, Calorie Restriction, and Rapamycin Treatment.

Basisty NB, Liu Y, Reynolds J, Karunadharma PP, Dai DF, Fredrickson J, Beyer RP, MacCoss MJ, Rabinovitch PS.

J Gerontol A Biol Sci Med Sci. 2018 Apr 17;73(5):561-570. doi: 10.1093/gerona/glx047.


Rapamycin treatment attenuates age-associated periodontitis in mice.

An JY, Quarles EK, Mekvanich S, Kang A, Liu A, Santos D, Miller RA, Rabinovitch PS, Cox TC, Kaeberlein M.

Geroscience. 2017 Sep 9. doi: 10.1007/s11357-017-9994-6. [Epub ahead of print]


Association of Aneuploidy and Flat Dysplasia With Development of High-Grade Dysplasia or Colorectal Cancer in Patients With Inflammatory Bowel Disease.

Tsai JH, Rabinovitch PS, Huang D, Small T, Mattis AN, Kakar S, Choi WT.

Gastroenterology. 2017 Dec;153(6):1492-1495.e4. doi: 10.1053/j.gastro.2017.08.031. Epub 2017 Aug 24.


Diagnosis and risk stratification of Barrett's dysplasia by flow cytometric DNA analysis of paraffin-embedded tissue.

Choi WT, Tsai JH, Rabinovitch PS, Small T, Huang D, Mattis AN, Kakar S.

Gut. 2018 Jul;67(7):1229-1238. doi: 10.1136/gutjnl-2017-313815. Epub 2017 Jun 22.


Mitochondrial-Targeted Catalase Protects Against High-Fat Diet-Induced Muscle Insulin Resistance by Decreasing Intramuscular Lipid Accumulation.

Lee HY, Lee JS, Alves T, Ladiges W, Rabinovitch PS, Jurczak MJ, Choi CS, Shulman GI, Samuel VT.

Diabetes. 2017 Aug;66(8):2072-2081. doi: 10.2337/db16-1334. Epub 2017 May 5.


Mitochondrial-Targeted Catalase: Extended Longevity and the Roles in Various Disease Models.

Dai DF, Chiao YA, Martin GM, Marcinek DJ, Basisty N, Quarles EK, Rabinovitch PS.

Prog Mol Biol Transl Sci. 2017;146:203-241. doi: 10.1016/bs.pmbts.2016.12.015. Epub 2017 Feb 4. Review.


The mitochondrial-targeted peptide, SS-31, improves glomerular architecture in mice of advanced age.

Sweetwyne MT, Pippin JW, Eng DG, Hudkins KL, Chiao YA, Campbell MD, Marcinek DJ, Alpers CE, Szeto HH, Rabinovitch PS, Shankland SJ.

Kidney Int. 2017 May;91(5):1126-1145. doi: 10.1016/j.kint.2016.10.036. Epub 2017 Jan 4.


Mitochondrial-targeted catalase is good for the old mouse proteome, but not for the young: 'reverse' antagonistic pleiotropy?

Basisty N, Dai DF, Gagnidze A, Gitari L, Fredrickson J, Maina Y, Beyer RP, Emond MJ, Hsieh EJ, MacCoss MJ, Martin GM, Rabinovitch PS.

Aging Cell. 2016 Aug;15(4):634-45. doi: 10.1111/acel.12472. Epub 2016 Apr 8.


Rapamycin transiently induces mitochondrial remodeling to reprogram energy metabolism in old hearts.

Chiao YA, Kolwicz SC, Basisty N, Gagnidze A, Zhang J, Gu H, Djukovic D, Beyer RP, Raftery D, MacCoss M, Tian R, Rabinovitch PS.

Aging (Albany NY). 2016 Feb;8(2):314-27.


Healthy aging: The ultimate preventative medicine.

Kaeberlein M, Rabinovitch PS, Martin GM.

Science. 2015 Dec 4;350(6265):1191-3. doi: 10.1126/science.aad3267. Review.


AMPK is critical for mitochondrial function during reperfusion after myocardial ischemia.

Zaha VG, Qi D, Su KN, Palmeri M, Lee HY, Hu X, Wu X, Shulman GI, Rabinovitch PS, Russell RR 3rd, Young LH.

J Mol Cell Cardiol. 2016 Feb;91:104-13. doi: 10.1016/j.yjmcc.2015.12.032. Epub 2015 Dec 30.


Age modifies respiratory complex I and protein homeostasis in a muscle type-specific manner.

Kruse SE, Karunadharma PP, Basisty N, Johnson R, Beyer RP, MacCoss MJ, Rabinovitch PS, Marcinek DJ.

Aging Cell. 2016 Feb;15(1):89-99. doi: 10.1111/acel.12412. Epub 2015 Oct 25.


The Aging Heart.

Chiao YA, Rabinovitch PS.

Cold Spring Harb Perspect Med. 2015 Sep 1;5(9):a025148. doi: 10.1101/cshperspect.a025148. Review.


Dose-dependent effects of mTOR inhibition on weight and mitochondrial disease in mice.

Johnson SC, Yanos ME, Bitto A, Castanza A, Gagnidze A, Gonzalez B, Gupta K, Hui J, Jarvie C, Johnson BM, Letexier N, McCanta L, Sangesland M, Tamis O, Uhde L, Van Den Ende A, Rabinovitch PS, Suh Y, Kaeberlein M.

Front Genet. 2015 Jul 22;6:247. doi: 10.3389/fgene.2015.00247. eCollection 2015.

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