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Items: 1 to 20 of 22

1.

USP7 cooperates with NOTCH1 to drive the oncogenic transcriptional program in T cell leukemia.

Jin Q, Martinez CA, Arcipowski KM, Zhu Y, Gutiérrez-Díaz BT, Wang KK, Johnson MR, Volk A, Wang F, Wu J, Grove C, Wang H, Sokirniy I, Thomas PM, Goo YA, Abshiru NA, Hijiya N, Peirs S, Vandamme N, Berx G, Goossens S, Marshall SA, Rendleman EJ, Takahashi YH, Wang L, Rawat R, Bartom ET, Collings CK, Van Vlierberghe P, Bourquin JP, Bornhauser B, Serafin V, Bresolin S, Paganin M, Accordi B, Basso G, Kelleher NL, Weinstock J, Suresh K, Crispino JD, Shilatifard A, Strikoudis A, Mantis C, Kandela I, Kelly S, Ueberheide B, Ntziachristos P.

Clin Cancer Res. 2018 Sep 17. pii: clincanres.1740.2018. doi: 10.1158/1078-0432.CCR-18-1740. [Epub ahead of print]

PMID:
30224337
2.

Resetting the epigenetic balance of Polycomb and COMPASS function at enhancers for cancer therapy.

Wang L, Zhao Z, Ozark PA, Fantini D, Marshall SA, Rendleman EJ, Cozzolino KA, Louis N, He X, Morgan MA, Takahashi YH, Collings CK, Smith ER, Ntziachristos P, Savas JN, Zou L, Hashizume R, Meeks JJ, Shilatifard A.

Nat Med. 2018 Jun;24(6):758-769. doi: 10.1038/s41591-018-0034-6. Epub 2018 May 21.

PMID:
29785026
3.

Stratification of TAD boundaries reveals preferential insulation of super-enhancers by strong boundaries.

Gong Y, Lazaris C, Sakellaropoulos T, Lozano A, Kambadur P, Ntziachristos P, Aifantis I, Tsirigos A.

Nat Commun. 2018 Feb 7;9(1):542. doi: 10.1038/s41467-018-03017-1.

4.

Opposing functions of H2BK120 ubiquitylation and H3K79 methylation in the regulation of pluripotency by the Paf1 complex.

Strikoudis A, Lazaris C, Ntziachristos P, Tsirigos A, Aifantis I.

Cell Cycle. 2017;16(24):2315-2322. doi: 10.1080/15384101.2017.1295194.

5.

HiC-bench: comprehensive and reproducible Hi-C data analysis designed for parameter exploration and benchmarking.

Lazaris C, Kelly S, Ntziachristos P, Aifantis I, Tsirigos A.

BMC Genomics. 2017 Jan 5;18(1):22. doi: 10.1186/s12864-016-3387-6.

6.

Deregulation of DUX4 and ERG in acute lymphoblastic leukemia.

Zhang J, McCastlain K, Yoshihara H, Xu B, Chang Y, Churchman ML, Wu G, Li Y, Wei L, Iacobucci I, Liu Y, Qu C, Wen J, Edmonson M, Payne-Turner D, Kaufmann KB, Takayanagi SI, Wienholds E, Waanders E, Ntziachristos P, Bakogianni S, Wang J, Aifantis I, Roberts KG, Ma J, Song G, Easton J, Mulder HL, Chen X, Newman S, Ma X, Rusch M, Gupta P, Boggs K, Vadodaria B, Dalton J, Liu Y, Valentine ML, Ding L, Lu C, Fulton RS, Fulton L, Tabib Y, Ochoa K, Devidas M, Pei D, Cheng C, Yang J, Evans WE, Relling MV, Pui CH, Jeha S, Harvey RC, Chen IL, Willman CL, Marcucci G, Bloomfield CD, Kohlschmidt J, Mrózek K, Paietta E, Tallman MS, Stock W, Foster MC, Racevskis J, Rowe JM, Luger S, Kornblau SM, Shurtleff SA, Raimondi SC, Mardis ER, Wilson RK, Dick JE, Hunger SP, Loh ML, Downing JR, Mullighan CG; St. Jude Children's Research Hospital–Washington University Pediatric Cancer Genome Project.

Nat Genet. 2016 Dec;48(12):1481-1489. doi: 10.1038/ng.3691. Epub 2016 Oct 24.

7.

Regulation of transcriptional elongation in pluripotency and cell differentiation by the PHD-finger protein Phf5a.

Strikoudis A, Lazaris C, Trimarchi T, Galvao Neto AL, Yang Y, Ntziachristos P, Rothbart S, Buckley S, Dolgalev I, Stadtfeld M, Strahl BD, Dynlacht BD, Tsirigos A, Aifantis I.

Nat Cell Biol. 2016 Nov;18(11):1127-1138. doi: 10.1038/ncb3424. Epub 2016 Oct 17.

8.

Emerging concepts of epigenetic dysregulation in hematological malignancies.

Ntziachristos P, Abdel-Wahab O, Aifantis I.

Nat Immunol. 2016 Sep;17(9):1016-24. doi: 10.1038/ni.3517. Epub 2016 Aug 1. Review.

9.

Histone demethylases in physiology and cancer: a tale of two enzymes, JMJD3 and UTX.

Arcipowski KM, Martinez CA, Ntziachristos P.

Curr Opin Genet Dev. 2016 Feb;36:59-67. doi: 10.1016/j.gde.2016.03.010. Epub 2016 May 3. Review.

10.

Cardiac Myocyte KLF5 Regulates Ppara Expression and Cardiac Function.

Drosatos K, Pollak NM, Pol CJ, Ntziachristos P, Willecke F, Valenti MC, Trent CM, Hu Y, Guo S, Aifantis I, Goldberg IJ.

Circ Res. 2016 Jan 22;118(2):241-53. doi: 10.1161/CIRCRESAHA.115.306383. Epub 2015 Nov 16.

11.

Control of embryonic stem cell identity by BRD4-dependent transcriptional elongation of super-enhancer-associated pluripotency genes.

Di Micco R, Fontanals-Cirera B, Low V, Ntziachristos P, Yuen SK, Lovell CD, Dolgalev I, Yonekubo Y, Zhang G, Rusinova E, Gerona-Navarro G, Cañamero M, Ohlmeyer M, Aifantis I, Zhou MM, Tsirigos A, Hernando E.

Cell Rep. 2014 Oct 9;9(1):234-247. doi: 10.1016/j.celrep.2014.08.055. Epub 2014 Sep 26.

12.

Contrasting roles of histone 3 lysine 27 demethylases in acute lymphoblastic leukaemia.

Ntziachristos P, Tsirigos A, Welstead GG, Trimarchi T, Bakogianni S, Xu L, Loizou E, Holmfeldt L, Strikoudis A, King B, Mullenders J, Becksfort J, Nedjic J, Paietta E, Tallman MS, Rowe JM, Tonon G, Satoh T, Kruidenier L, Prinjha R, Akira S, Van Vlierberghe P, Ferrando AA, Jaenisch R, Mullighan CG, Aifantis I.

Nature. 2014 Oct 23;514(7523):513-7. doi: 10.1038/nature13605. Epub 2014 Aug 17.

13.

Genome-wide mapping and characterization of Notch-regulated long noncoding RNAs in acute leukemia.

Trimarchi T, Bilal E, Ntziachristos P, Fabbri G, Dalla-Favera R, Tsirigos A, Aifantis I.

Cell. 2014 Jul 31;158(3):593-606. doi: 10.1016/j.cell.2014.05.049.

14.

From fly wings to targeted cancer therapies: a centennial for notch signaling.

Ntziachristos P, Lim JS, Sage J, Aifantis I.

Cancer Cell. 2014 Mar 17;25(3):318-34. doi: 10.1016/j.ccr.2014.02.018. Review.

15.

The RAG2 C-terminus and ATM protect genome integrity by controlling antigen receptor gene cleavage.

Chaumeil J, Micsinai M, Ntziachristos P, Roth DB, Aifantis I, Kluger Y, Deriano L, Skok JA.

Nat Commun. 2013;4:2231. doi: 10.1038/ncomms3231.

16.

A new player SETs in myeloid malignancy.

Trimarchi T, Ntziachristos P, Aifantis I.

Nat Genet. 2013 Aug;45(8):846-7. doi: 10.1038/ng.2709.

17.

The ubiquitin ligase FBXW7 modulates leukemia-initiating cell activity by regulating MYC stability.

King B, Trimarchi T, Reavie L, Xu L, Mullenders J, Ntziachristos P, Aranda-Orgilles B, Perez-Garcia A, Shi J, Vakoc C, Sandy P, Shen SS, Ferrando A, Aifantis I.

Cell. 2013 Jun 20;153(7):1552-66. doi: 10.1016/j.cell.2013.05.041.

18.

Mechanisms of epigenetic regulation of leukemia onset and progression.

Ntziachristos P, Mullenders J, Trimarchi T, Aifantis I.

Adv Immunol. 2013;117:1-38. doi: 10.1016/B978-0-12-410524-9.00001-3. Review.

19.

Higher-order looping and nuclear organization of Tcra facilitate targeted rag cleavage and regulated rearrangement in recombination centers.

Chaumeil J, Micsinai M, Ntziachristos P, Deriano L, Wang JM, Ji Y, Nora EP, Rodesch MJ, Jeddeloh JA, Aifantis I, Kluger Y, Schatz DG, Skok JA.

Cell Rep. 2013 Feb 21;3(2):359-70. doi: 10.1016/j.celrep.2013.01.024. Epub 2013 Feb 14.

20.

Notch pathway activation targets AML-initiating cell homeostasis and differentiation.

Lobry C, Ntziachristos P, Ndiaye-Lobry D, Oh P, Cimmino L, Zhu N, Araldi E, Hu W, Freund J, Abdel-Wahab O, Ibrahim S, Skokos D, Armstrong SA, Levine RL, Park CY, Aifantis I.

J Exp Med. 2013 Feb 11;210(2):301-19. doi: 10.1084/jem.20121484. Epub 2013 Jan 28.

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