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1.

18F-JNJ-64413739, a novel PET ligand for the P2X7 ion channel: radiation dosimetry, kinetic modeling, test-retest variability and occupancy of the P2X7 antagonist JNJ-54175446.

Koole M, Schmidt M, Hijzen A, Ravenstijn P, Vandermeulen C, Van Weehaeghe D, Serdons K, Celen S, Bormans G, Ceusters M, Zhang W, Van Nueten L, Kolb H, de Hoon J, Van Laere K.

J Nucl Med. 2018 Sep 27. pii: jnumed.118.216747. doi: 10.2967/jnumed.118.216747. [Epub ahead of print]

PMID:
30262518
2.

Relationship between In Vivo CYP3A4 Activity, CYP3A5 Genotype, and Systemic Tacrolimus Metabolite/Parent Drug Ratio in Renal Transplant Recipients and Healthy Volunteers.

Vanhove T, de Jonge H, de Loor H, Oorts M, de Hoon J, Pohanka A, Annaert P, Kuypers DRJ.

Drug Metab Dispos. 2018 Nov;46(11):1507-1513. doi: 10.1124/dmd.118.081935. Epub 2018 Aug 30.

PMID:
30166405
3.

Presence of aortic root vortex formation after TAVI with CENTERA confirmed using 4D-flow magnetic resonance imaging.

Vendrik J, Farag ES, de Hoon NHLC, Kluin J, Baan J Jr.

Int J Cardiovasc Imaging. 2018 Dec;34(12):1947-1948. doi: 10.1007/s10554-018-1413-2. Epub 2018 Aug 9. No abstract available.

PMID:
30094565
4.

RVCL-S and CADASIL display distinct impaired vascular function.

de Boer I, Stam AH, Buntinx L, Zielman R, van der Steen I, van den Maagdenberg AMJM, de Koning EJP, Ferrari MD, de Hoon JN, Terwindt GM.

Neurology. 2018 Sep 4;91(10):e956-e963. doi: 10.1212/WNL.0000000000006119. Epub 2018 Aug 3.

PMID:
30076273
5.

X chromosome inactivation in a female carrier of a 1.28 Mb deletion encompassing the human X inactivation centre.

de Hoon B, Splinter E, Eussen B, Douben JCW, Rentmeester E, van de Heijning M, Laven JSE, de Klein JEMM, Liebelt J, Gribnau J.

Philos Trans R Soc Lond B Biol Sci. 2017 Nov 5;372(1733). pii: 20160359. doi: 10.1098/rstb.2016.0359.

6.

Body weight, gender and pregnancy affect enantiomer-specific ketorolac pharmacokinetics.

Välitalo PA, Kemppainen H, Kulo A, Smits A, van Calsteren K, Olkkola KT, de Hoon J, Knibbe CAJ, Allegaert K.

Br J Clin Pharmacol. 2017 Sep;83(9):1966-1975. doi: 10.1111/bcp.13311. Epub 2017 May 14.

7.

Analysis of the human monocyte-derived macrophage transcriptome and response to lipopolysaccharide provides new insights into genetic aetiology of inflammatory bowel disease.

Baillie JK, Arner E, Daub C, De Hoon M, Itoh M, Kawaji H, Lassmann T, Carninci P, Forrest AR, Hayashizaki Y; FANTOM Consortium, Faulkner GJ, Wells CA, Rehli M, Pavli P, Summers KM, Hume DA.

PLoS Genet. 2017 Mar 6;13(3):e1006641. doi: 10.1371/journal.pgen.1006641. eCollection 2017 Mar.

8.

Enantiomer-specific ketorolac pharmacokinetics in young women, including pregnancy and postpartum period.

Kulo A, Smits A, Maleškić S, Van de Velde M, Van Calsteren K, De Hoon J, Verbesselt R, Deprest J, Allegaert K.

Bosn J Basic Med Sci. 2017 Feb 21;17(1):54-60. doi: 10.17305/bjbms.2016.1515.

9.

Development of an in vivo target-engagement biomarker for TRPA1 antagonists in humans.

Buntinx L, Chang L, Amin A, Morlion B, de Hoon J.

Br J Clin Pharmacol. 2017 Mar;83(3):603-611. doi: 10.1111/bcp.13143. Epub 2016 Nov 17.

10.

What We Observe In Vivo Is Not Always What We See In Vitro: Development and Validation of 11C-JNJ-42491293, A Novel Radioligand for mGluR2.

Leurquin-Sterk G, Celen S, Van Laere K, Koole M, Bormans G, Langlois X, Van Hecken A, Te Riele P, Alcázar J, Verbruggen A, de Hoon J, Andrés JI, Schmidt ME.

J Nucl Med. 2017 Jan;58(1):110-116. doi: 10.2967/jnumed.116.176628. Epub 2016 Jul 28.

11.

Drug disposition before and after gastric bypass: fenofibrate and posaconazole.

Gesquiere I, Hens B, Van der Schueren B, Mols R, de Hoon J, Lannoo M, Matthys C, Foulon V, Augustijns P.

Br J Clin Pharmacol. 2016 Nov;82(5):1325-1332. doi: 10.1111/bcp.13054. Epub 2016 Jul 25.

12.

Pharmacokinetics and Pharmacodynamics of Omarigliptin, a Once-Weekly Dipeptidyl Peptidase-4 (DPP-4) Inhibitor, After Single and Multiple Doses in Healthy Subjects.

Krishna R, Addy C, Tatosian D, Glasgow XS, Gendrano Iii IN, Robberechts M, Haazen W, de Hoon JN, Depré M, Martucci A, Peng JZ, Johnson-Levonas AO, Wagner JA, Stoch SA.

J Clin Pharmacol. 2016 Dec;56(12):1528-1537. doi: 10.1002/jcph.773. Epub 2016 Jun 17.

13.

Fitting the Puzzle Pieces: the Bigger Picture of XCI.

Maduro C, de Hoon B, Gribnau J.

Trends Biochem Sci. 2016 Feb;41(2):138-147. doi: 10.1016/j.tibs.2015.12.003. Epub 2016 Jan 13. Review.

PMID:
26796628
14.

Quantification, Variability, and Reproducibility of Basal Skeletal Muscle Glucose Uptake in Healthy Humans Using 18F-FDG PET/CT.

Gheysens O, Postnov A, Deroose CM, Vandermeulen C, de Hoon J, Declercq R, Dennie J, Mixson L, De Lepeleire I, Van Laere K, Klimas M, Chakravarthy MV.

J Nucl Med. 2015 Oct;56(10):1520-6. doi: 10.2967/jnumed.115.159715. Epub 2015 Jul 30.

15.

Buccal swab as a reliable predictor for X inactivation ratio in inaccessible tissues.

de Hoon B, Monkhorst K, Riegman P, Laven JS, Gribnau J.

J Med Genet. 2015 Nov;52(11):784-90. doi: 10.1136/jmedgenet-2015-103194. Epub 2015 Jul 28.

16.

Developmental changes rather than repeated administration drive paracetamol glucuronidation in neonates and infants.

Krekels EH, van Ham S, Allegaert K, de Hoon J, Tibboel D, Danhof M, Knibbe CA.

Eur J Clin Pharmacol. 2015 Sep;71(9):1075-82. doi: 10.1007/s00228-015-1887-y. Epub 2015 Jul 3.

17.

Translational Pharmacodynamics of Calcitonin Gene-Related Peptide Monoclonal Antibody LY2951742 in a Capsaicin-Induced Dermal Blood Flow Model.

Vermeersch S, Benschop RJ, Van Hecken A, Monteith D, Wroblewski VJ, Grayzel D, de Hoon J, Collins EC.

J Pharmacol Exp Ther. 2015 Sep;354(3):350-7. doi: 10.1124/jpet.115.224212. Epub 2015 Jun 26.

18.

Development of anti-migraine therapeutics using the capsaicin-induced dermal blood flow model.

Buntinx L, Vermeersch S, de Hoon J.

Br J Clin Pharmacol. 2015 Nov;80(5):992-1000. doi: 10.1111/bcp.12704. Epub 2015 Oct 6. Review.

19.

Batf2/Irf1 induces inflammatory responses in classically activated macrophages, lipopolysaccharides, and mycobacterial infection.

Roy S, Guler R, Parihar SP, Schmeier S, Kaczkowski B, Nishimura H, Shin JW, Negishi Y, Ozturk M, Hurdayal R, Kubosaki A, Kimura Y, de Hoon MJ, Hayashizaki Y, Brombacher F, Suzuki H.

J Immunol. 2015 Jun 15;194(12):6035-44. doi: 10.4049/jimmunol.1402521. Epub 2015 May 8.

20.

Drug disposition and modelling before and after gastric bypass: immediate and controlled-release metoprolol formulations.

Gesquiere I, Darwich AS, Van der Schueren B, de Hoon J, Lannoo M, Matthys C, Rostami A, Foulon V, Augustijns P.

Br J Clin Pharmacol. 2015 Nov;80(5):1021-30. doi: 10.1111/bcp.12666. Epub 2015 Jul 6.

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