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Items: 15

1.

Molecular modeling, dynamics simulations, and binding efficiency of berberine derivatives: A new group of RAF inhibitors for cancer treatment.

Jabbarzadeh Kaboli P, Ismail P, Ling KH.

PLoS One. 2018 Mar 22;13(3):e0193941. doi: 10.1371/journal.pone.0193941. eCollection 2018.

2.

Design, synthesis and anticancer evaluation of novel spirobenzo[h]chromene and spirochromane derivatives with dual EGFR and B-RAF inhibitory activities.

Abdelatef SA, El-Saadi MT, Amin NH, Abdelazeem AH, Omar HA, Abdellatif KRA.

Eur J Med Chem. 2018 Apr 25;150:567-578. doi: 10.1016/j.ejmech.2018.03.001. Epub 2018 Mar 5.

PMID:
29549841
3.

A cellular threshold for active ERK1/2 levels determines Raf/MEK/ERK-mediated growth arrest versus death responses.

Hong SK, Wu PK, Park JI.

Cell Signal. 2018 Jan;42:11-20. doi: 10.1016/j.cellsig.2017.10.001. Epub 2017 Oct 3.

PMID:
28986121
4.

Design and synthesis of new RAF kinase-inhibiting antiproliferative quinoline derivatives. Part 2: Diarylurea derivatives.

El-Gamal MI, Khan MA, Tarazi H, Abdel-Maksoud MS, Gamal El-Din MM, Yoo KH, Oh CH.

Eur J Med Chem. 2017 Feb 15;127:413-423. doi: 10.1016/j.ejmech.2017.01.006. Epub 2017 Jan 5.

PMID:
28088086
5.

Design and synthesis of new 2-anilinoquinolines bearing N-methylpicolinamide moiety as potential antiproliferative agents.

El-Damasy AK, Seo SH, Cho NC, Pae AN, Kim EE, Keum G.

Chem Biol Drug Des. 2017 Jan;89(1):98-113. doi: 10.1111/cbdd.12836. Epub 2016 Sep 9.

PMID:
27496071
6.

Quinoxalinone (Part II). Discovery of (Z)-3-(2-(pyridin-4-yl)vinyl)quinoxalinone derivates as potent VEGFR-2 kinase inhibitors.

Shi L, Zhou J, Wu J, Cao J, Shen Y, Zhou H, Li X.

Bioorg Med Chem. 2016 Apr 15;24(8):1840-52. doi: 10.1016/j.bmc.2016.03.008. Epub 2016 Mar 3.

PMID:
26968648
7.

Design, synthesis, in-vitro antiproliferative activity and kinase profile of new picolinamide based 2-amido and ureido quinoline derivatives.

El-Damasy AK, Seo SH, Cho NC, Kang SB, Pae AN, Kim KS, Keum G.

Eur J Med Chem. 2015 Aug 28;101:754-68. doi: 10.1016/j.ejmech.2015.07.025. Epub 2015 Jul 17.

PMID:
26218653
8.

FGF2 Prevents Sunitinib-Induced Cardiotoxicity in Zebrafish and Cardiomyoblast H9c2 Cells.

Cui G, Chen H, Cui W, Guo X, Fang J, Liu A, Chen Y, Lee SM.

Cardiovasc Toxicol. 2016 Jan;16(1):46-53. doi: 10.1007/s12012-015-9315-1.

PMID:
25701259
9.

Active ERK2 is sufficient to mediate growth arrest and differentiation signaling.

Wu PK, Hong SK, Yoon SH, Park JI.

FEBS J. 2015 Mar;282(6):1017-30. doi: 10.1111/febs.13197. Epub 2015 Feb 3.

11.
12.

Wentilactone B induces G2/M phase arrest and apoptosis via the Ras/Raf/MAPK signaling pathway in human hepatoma SMMC-7721 cells.

Zhang Z, Miao L, Lv C, Sun H, Wei S, Wang B, Huang C, Jiao B.

Cell Death Dis. 2013 Jun 6;4:e657. doi: 10.1038/cddis.2013.182.

13.

In silico binding free energy predictability with π-π interaction energy-augmented scoring function: benzimidazole Raf inhibitors as a case study.

Chung JY, Cho SJ, Cho AE, Hah JM.

Bioorg Med Chem Lett. 2012 May 1;22(9):3278-83. doi: 10.1016/j.bmcl.2012.03.017. Epub 2012 Mar 14.

PMID:
22464457
14.

CNK and HYP form a discrete dimer by their SAM domains to mediate RAF kinase signaling.

Rajakulendran T, Sahmi M, Kurinov I, Tyers M, Therrien M, Sicheri F.

Proc Natl Acad Sci U S A. 2008 Feb 26;105(8):2836-41. doi: 10.1073/pnas.0709705105. Epub 2008 Feb 19.

15.

Interactions between Ras and Raf: key regulatory proteins in cellular transformation.

Marshall M.

Mol Reprod Dev. 1995 Dec;42(4):493-9. Review.

PMID:
8607981

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