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Items: 20

1.

Pharmacophore based design of some multi-targeted compounds targeted against pathways of diabetic complications.

Chadha N, Silakari O.

J Mol Graph Model. 2017 Sep;76:412-418. doi: 10.1016/j.jmgm.2017.07.020. Epub 2017 Jul 21.

PMID:
28802212
2.

Fumigaclavine C exhibits anti-inflammatory effects by suppressing high mobility group box protein 1 relocation and release.

Yu W, Pan Z, Zhu Y, An F, Lu Y.

Eur J Pharmacol. 2017 Oct 5;812:234-242. doi: 10.1016/j.ejphar.2017.06.008. Epub 2017 Jun 10.

PMID:
28610842
3.

Indolyl-naphthyl-maleimides as potent and selective inhibitors of protein kinase C-α/β.

van Eis MJ, Evenou J, Schuler W, Zenke G, Vangrevelinghe E, Wagner J, von Matt P.

Bioorg Med Chem Lett. 2017 Feb 15;27(4):781-786. doi: 10.1016/j.bmcl.2017.01.038. Epub 2017 Jan 16.

PMID:
28131714
5.

Regulations of Reversal of Senescence by PKC Isozymes in Response to 12-O-Tetradecanoylphorbol-13-Acetate via Nuclear Translocation of pErk1/2.

Lee YY, Ryu MS, Kim HS, Suganuma M, Song KY, Lim IK.

Mol Cells. 2016 Mar;39(3):266-79. doi: 10.14348/molcells.2016.2362. Epub 2016 Feb 24.

6.

Delineation of Platelet Activation Pathway of Scutellarein Revealed Its Intracellular Target as Protein Kinase C.

Tian X, Chang L, Ma G, Wang T, Lv M, Wang Z, Chen L, Wang Y, Gao X, Zhu Y.

Biol Pharm Bull. 2016;39(2):181-91. doi: 10.1248/bpb.b15-00511. Epub 2015 Nov 18.

7.

Intramolecular C2 Domain-Mediated Autoinhibition of Protein Kinase C βII.

Antal CE, Callender JA, Kornev AP, Taylor SS, Newton AC.

Cell Rep. 2015 Aug 25;12(8):1252-60. doi: 10.1016/j.celrep.2015.07.039. Epub 2015 Aug 13.

8.

Molecular dynamics approach to probe PKCβII-ligand interactions and influence of crystal water molecules on these interactions.

Grewal BK, Bhat J, Sobhia ME.

Expert Opin Ther Targets. 2015 Jan;19(1):13-23. doi: 10.1517/14728222.2014.975795. Epub 2014 Nov 1.

PMID:
25363346
9.

Discovery and optimization of 1,3,5-trisubstituted pyrazolines as potent and highly selective allosteric inhibitors of protein kinase C-ζ.

Abdel-Halim M, Diesel B, Kiemer AK, Abadi AH, Hartmann RW, Engel M.

J Med Chem. 2014 Aug 14;57(15):6513-30. doi: 10.1021/jm500521n. Epub 2014 Jul 24.

PMID:
25058929
10.

Structural basis of conformational variance in phosphorylated and non-phosphorylated states of PKCβII.

Grewal BK, Krishnan RV, Sobhia ME.

Proteins. 2014 Jul;82(7):1332-47.

PMID:
25050443
11.

HDAC inhibition through valproic acid modulates the methylation profiles in human embryonic kidney cells.

Ganai SA, Kalladi SM, Mahadevan V.

J Biomol Struct Dyn. 2015;33(6):1185-97. doi: 10.1080/07391102.2014.938247. Epub 2014 Jul 11.

PMID:
25012937
12.

Computational investigation of pkcβ inhibitors for the treatment of diabetic retinopathy.

Gogula SV, Divakar Ch, Satyanarayana Ch, Kumar YP, Lavanaya VS.

Bioinformation. 2013 Dec 27;9(20):1040-3. doi: 10.6026/97320630091040. eCollection 2013.

13.

AChE and RACK1 promote the anti-inflammatory properties of fluoxetine.

Waiskopf N, Ofek K, Gilboa-Geffen A, Bekenstein U, Bahat A, Bennett ER, Podoly E, Livnah O, Hartmann G, Soreq H.

J Mol Neurosci. 2014 Jul;53(3):306-15. doi: 10.1007/s12031-013-0174-6. Epub 2013 Nov 21.

PMID:
24258317
14.
15.

Heterozygous mis-sense mutations in Prkcb as a critical determinant of anti-polysaccharide antibody formation.

Teh CE, Horikawa K, Arnold CN, Beutler B, Kucharska EM, Vinuesa CG, Bertram EM, Goodnow CC, Enders A.

Genes Immun. 2013 Jun;14(4):223-33. doi: 10.1038/gene.2013.11. Epub 2013 Apr 4.

16.
17.

Protein kinase C βII in diabetic complications: survey of structural, biological and computational studies.

Sobhia ME, Grewal BK, Bhat J, Rohit S, Punia V.

Expert Opin Ther Targets. 2012 Mar;16(3):325-44. doi: 10.1517/14728222.2012.667804. Review.

PMID:
22404224
18.

C2 domains of protein kinase C isoforms alpha, beta, and gamma: activation parameters and calcium stoichiometries of the membrane-bound state.

Kohout SC, Corbalán-García S, Torrecillas A, Goméz-Fernandéz JC, Falke JJ.

Biochemistry. 2002 Sep 24;41(38):11411-24.

19.

The Protein-tyrosine-phosphatase SHP2 is phosphorylated on serine residues 576 and 591 by protein kinase C isoforms alpha, beta 1, beta 2, and eta.

Strack V, Krützfeldt J, Kellerer M, Ullrich A, Lammers R, Häring HU.

Biochemistry. 2002 Jan 15;41(2):603-8.

PMID:
11781100
20.

C2 domains from different Ca2+ signaling pathways display functional and mechanistic diversity.

Nalefski EA, Wisner MA, Chen JZ, Sprang SR, Fukuda M, Mikoshiba K, Falke JJ.

Biochemistry. 2001 Mar 13;40(10):3089-100.

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