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Items: 1 to 20 of 61


Interacting-heads motif has been conserved as a mechanism of myosin II inhibition since before the origin of animals.

Lee KH, Sulbarán G, Yang S, Mun JY, Alamo L, Pinto A, Sato O, Ikebe M, Liu X, Korn ED, Sarsoza F, Bernstein SI, Padrón R, Craig R.

Proc Natl Acad Sci U S A. 2018 Feb 27;115(9):E1991-E2000. doi: 10.1073/pnas.1715247115. Epub 2018 Feb 14.


Lessons from a tarantula: new insights into muscle thick filament and myosin interacting-heads motif structure and function.

Alamo L, Koubassova N, Pinto A, Gillilan R, Tsaturyan A, Padrón R.

Biophys Rev. 2017 Oct;9(5):461-480. doi: 10.1007/s12551-017-0295-1. Epub 2017 Sep 4. Review.


Lessons from a tarantula: new insights into myosin interacting-heads motif evolution and its implications on disease.

Alamo L, Pinto A, Sulbarán G, Mavárez J, Padrón R.

Biophys Rev. 2018 Oct;10(5):1465-1477. doi: 10.1007/s12551-017-0292-4. Epub 2017 Sep 4. Review.


Effects of myosin variants on interacting-heads motif explain distinct hypertrophic and dilated cardiomyopathy phenotypes.

Alamo L, Ware JS, Pinto A, Gillilan RE, Seidman JG, Seidman CE, Padrón R.

Elife. 2017 Jun 13;6. pii: e24634. doi: 10.7554/eLife.24634.


Conserved Intramolecular Interactions Maintain Myosin Interacting-Heads Motifs Explaining Tarantula Muscle Super-Relaxed State Structural Basis.

Alamo L, Qi D, Wriggers W, Pinto A, Zhu J, Bilbao A, Gillilan RE, Hu S, Padrón R.

J Mol Biol. 2016 Mar 27;428(6):1142-1164. doi: 10.1016/j.jmb.2016.01.027. Epub 2016 Feb 2.


An invertebrate smooth muscle with striated muscle myosin filaments.

Sulbarán G, Alamo L, Pinto A, Márquez G, Méndez F, Padrón R, Craig R.

Proc Natl Acad Sci U S A. 2015 Oct 20;112(42):E5660-8. doi: 10.1073/pnas.1513439112. Epub 2015 Oct 6.


Tarantula myosin free head regulatory light chain phosphorylation stiffens N-terminal extension, releasing it and blocking its docking back.

Alamo L, Li XE, Espinoza-Fonseca LM, Pinto A, Thomas DD, Lehman W, Padrón R.

Mol Biosyst. 2015 Aug;11(8):2180-9. doi: 10.1039/c5mb00163c.


Sequential myosin phosphorylation activates tarantula thick filament via a disorder-order transition.

Espinoza-Fonseca LM, Alamo L, Pinto A, Thomas DD, Padrón R.

Mol Biosyst. 2015 Aug;11(8):2167-79. doi: 10.1039/c5mb00162e.


A method for 3D-reconstruction of a muscle thick filament using the tilt series images of a single filament electron tomogram.

Márquez G, Pinto A, Alamo L, Baumann B, Ye F, Winkler H, Taylor K, Padrón R.

J Struct Biol. 2014 May;186(2):265-72. doi: 10.1016/j.jsb.2014.04.003. Epub 2014 Apr 12.


Different head environments in tarantula thick filaments support a cooperative activation process.

Sulbarán G, Biasutto A, Alamo L, Riggs C, Pinto A, Méndez F, Craig R, Padrón R.

Biophys J. 2013 Nov 5;105(9):2114-22. doi: 10.1016/j.bpj.2013.09.001.


The myosin interacting-heads motif is present in the relaxed thick filament of the striated muscle of scorpion.

Pinto A, Sánchez F, Alamo L, Padrón R.

J Struct Biol. 2012 Dec;180(3):469-78. doi: 10.1016/j.jsb.2012.08.010. Epub 2012 Sep 7.


A molecular model of phosphorylation-based activation and potentiation of tarantula muscle thick filaments.

Brito R, Alamo L, Lundberg U, Guerrero JR, Pinto A, Sulbarán G, Gawinowicz MA, Craig R, Padrón R.

J Mol Biol. 2011 Nov 18;414(1):44-61. doi: 10.1016/j.jmb.2011.09.017. Epub 2011 Sep 17. Erratum in: J Mol Biol. 2014 Jan 9;426(1):272.


Direct visualization of myosin-binding protein C bridging myosin and actin filaments in intact muscle.

Luther PK, Winkler H, Taylor K, Zoghbi ME, Craig R, Padrón R, Squire JM, Liu J.

Proc Natl Acad Sci U S A. 2011 Jul 12;108(28):11423-8. doi: 10.1073/pnas.1103216108. Epub 2011 Jun 24.


Matching structural densities from different biophysical origins with gain and bias.

Wriggers W, Alamo L, Padrón R.

J Struct Biol. 2011 Mar;173(3):445-50. doi: 10.1016/j.jsb.2010.09.012. Epub 2010 Sep 18.


Three-dimensional reconstruction of tarantula myosin filaments suggests how phosphorylation may regulate myosin activity.

Alamo L, Wriggers W, Pinto A, Bártoli F, Salazar L, Zhao FQ, Craig R, Padrón R.

J Mol Biol. 2008 Dec 26;384(4):780-97. doi: 10.1016/j.jmb.2008.10.013. Epub 2008 Oct 14.


Understanding the organisation and role of myosin binding protein C in normal striated muscle by comparison with MyBP-C knockout cardiac muscle.

Luther PK, Bennett PM, Knupp C, Craig R, Padrón R, Harris SP, Patel J, Moss RL.

J Mol Biol. 2008 Dec 5;384(1):60-72. doi: 10.1016/j.jmb.2008.09.013. Epub 2008 Sep 16.


Blebbistatin stabilizes the helical order of myosin filaments by promoting the switch 2 closed state.

Zhao FQ, Padrón R, Craig R.

Biophys J. 2008 Oct;95(7):3322-9. doi: 10.1529/biophysj.108.137067. Epub 2008 Jul 3.


Atomic model of a myosin filament in the relaxed state.

Woodhead JL, Zhao FQ, Craig R, Egelman EH, Alamo L, Padrón R.

Nature. 2005 Aug 25;436(7054):1195-9.


Helical order in tarantula thick filaments requires the "closed" conformation of the myosin head.

Zoghbi ME, Woodhead JL, Craig R, Padrón R.

J Mol Biol. 2004 Sep 24;342(4):1223-36.


[Familial hypertrophic cardiomyopathy: genes, mutations and animal models. A review].

Ramírez CD, Padrón R.

Invest Clin. 2004 Mar;45(1):69-99. Review. Spanish.


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