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Items: 1 to 20 of 81


Human enterovirus group B viruses rely on vimentin dynamics for efficient processing of viral non-structural proteins.

Turkki P, Laajala M, Flodström-Tullberg M, Marjomäki V.

J Virol. 2019 Oct 16. pii: JVI.01393-19. doi: 10.1128/JVI.01393-19. [Epub ahead of print]


Formalin treatment increases the stability and immunogenicity of coxsackievirus B1 VLP vaccine.

Hankaniemi MM, Stone VM, Andrejeff T, Heinimäki S, Sioofy-Khojine AB, Marjomäki V, Hyöty H, Blazevic V, Flodström-Tullberg M, Hytönen VP, Laitinen OH.

Antiviral Res. 2019 Nov;171:104595. doi: 10.1016/j.antiviral.2019.104595. Epub 2019 Sep 3.


A comparative study of the effect of UV and formalin inactivation on the stability and immunogenicity of a Coxsackievirus B1 vaccine.

Hankaniemi MM, Stone VM, Sioofy-Khojine AB, Heinimäki S, Marjomäki V, Hyöty H, Blazevic V, Laitinen OH, Flodström-Tullberg M, Hytönen VP.

Vaccine. 2019 Sep 20;37(40):5962-5971. doi: 10.1016/j.vaccine.2019.08.037. Epub 2019 Aug 27.


Coxsackievirus B Persistence Modifies the Proteome and the Secretome of Pancreatic Ductal Cells.

Lietzén N, Hirvonen K, Honkimaa A, Buchacher T, Laiho JE, Oikarinen S, Mazur MA, Flodström-Tullberg M, Dufour E, Sioofy-Khojine AB, Hyöty H, Lahesmaa R.

iScience. 2019 Sep 27;19:340-357. doi: 10.1016/j.isci.2019.07.040. Epub 2019 Jul 29.


Genetic and Environmental Interaction in Type 1 Diabetes: a Relationship Between Genetic Risk Alleles and Molecular Traits of Enterovirus Infection?

Blanter M, Sork H, Tuomela S, Flodström-Tullberg M.

Curr Diab Rep. 2019 Aug 10;19(9):82. doi: 10.1007/s11892-019-1192-8. Review.


Short-term CFTR inhibition reduces islet area in C57BL/6 mice.

Khan D, Kelsey R, Maheshwari RR, Stone VM, Hasib A, Manderson Koivula FN, Watson A, Harkin S, Irwin N, Shaw JA, McClenaghan NH, Venglovecz V, Ébert A, Flodström-Tullberg M, White MG, Kelly C.

Sci Rep. 2019 Aug 2;9(1):11244. doi: 10.1038/s41598-019-47745-w.


Large enteroviral vaccination studies to prevent type 1 diabetes should be well founded and rely on scientific evidence. Reply to Skog O, Klingel K, Roivainen M et al [letter].

Dunne JL, Richardson SJ, Atkinson MA, Craig ME, Dahl-Jørgensen K, Flodström-Tullberg M, Hyöty H, Lloyd RE, Morgan NG, Pugliese A.

Diabetologia. 2019 Jun;62(6):1100-1103. doi: 10.1007/s00125-019-4873-6. Epub 2019 Apr 23. No abstract available.


Defective exocytosis and processing of insulin in a cystic fibrosis mouse model.

Edlund A, Barghouth M, Huhn M, Abels M, Esguerra J, Mollet I, Svedin E, Wendt A, Renstrom E, Zhang E, Wierup N, Scholte BJ, Flodström-Tullberg M, Eliasson L.

J Endocrinol. 2019 Feb 1. pii: JOE-18-0570.R1. doi: 10.1530/JOE-18-0570. [Epub ahead of print]


Rationale for enteroviral vaccination and antiviral therapies in human type 1 diabetes.

Dunne JL, Richardson SJ, Atkinson MA, Craig ME, Dahl-Jørgensen K, Flodström-Tullberg M, Hyöty H, Insel RA, Lernmark Å, Lloyd RE, Morgan NG, Pugliese A.

Diabetologia. 2019 May;62(5):744-753. doi: 10.1007/s00125-019-4811-7. Epub 2019 Jan 23.


Severely Impaired Control of Bacterial Infections in a Patient With Cystic Fibrosis Defective in Mucosal-Associated Invariant T Cells.

Pincikova T, Paquin-Proulx D, Moll M, Flodström-Tullberg M, Hjelte L, Sandberg JK.

Chest. 2018 May;153(5):e93-e96. doi: 10.1016/j.chest.2018.01.020.


New Coxsackievirus 2Apro and 3Cpro protease antibodies for virus detection and discovery of pathogenic mechanisms.

Laitinen OH, Svedin E, Kapell S, Hankaniemi MM, Larsson PG, Domsgen E, Stone VM, Määttä JAE, Hyöty H, Hytönen VP, Flodström-Tullberg M.

J Virol Methods. 2018 May;255:29-37. doi: 10.1016/j.jviromet.2018.02.001. Epub 2018 Feb 6.


A novel rat CVB1-VP1 monoclonal antibody 3A6 detects a broad range of enteroviruses.

Saarinen NVV, Laiho JE, Richardson SJ, Zeissler M, Stone VM, Marjomäki V, Kantoluoto T, Horwitz MS, Sioofy-Khojine A, Honkimaa A, Hankaniemi MM, Flodström-Tullberg M, Hyöty H, Hytönen VP, Laitinen OH.

Sci Rep. 2018 Jan 8;8(1):33. doi: 10.1038/s41598-017-18495-4.


A Coxsackievirus B vaccine protects against virus-induced diabetes in an experimental mouse model of type 1 diabetes.

Stone VM, Hankaniemi MM, Svedin E, Sioofy-Khojine A, Oikarinen S, Hyöty H, Laitinen OH, Hytönen VP, Flodström-Tullberg M.

Diabetologia. 2018 Feb;61(2):476-481. doi: 10.1007/s00125-017-4492-z. Epub 2017 Nov 18.


A Link Between a Common Mutation in CFTR and Impaired Innate and Adaptive Viral Defense.

Svedin E, Utorova R, Hühn MH, Larsson PG, Stone VM, Garimella M, Lind K, Hägglöf T, Pincikova T, Laitinen OH, McInerney GM, Scholte B, Hjelte L, Karlsson MCI, Flodström-Tullberg M.

J Infect Dis. 2017 Dec 5;216(10):1308-1317. doi: 10.1093/infdis/jix474.


Composition and functionality of the intrahepatic innate lymphoid cell-compartment in human nonfibrotic and fibrotic livers.

Forkel M, Berglin L, Kekäläinen E, Carlsson A, Svedin E, Michaëlsson J, Nagasawa M, Erjefält JS, Mori M, Flodström-Tullberg M, Bergquist A, Ljunggren HG, Westgren M, Lindforss U, Friberg D, Jorns C, Ellis E, Björkström NK, Mjösberg J.

Eur J Immunol. 2017 Aug;47(8):1280-1294. doi: 10.1002/eji.201646890. Epub 2017 Jul 11.


Optimized production and purification of Coxsackievirus B1 vaccine and its preclinical evaluation in a mouse model.

Hankaniemi MM, Laitinen OH, Stone VM, Sioofy-Khojine A, Määttä JAE, Larsson PG, Marjomäki V, Hyöty H, Flodström-Tullberg M, Hytönen VP.

Vaccine. 2017 Jun 27;35(30):3718-3725. doi: 10.1016/j.vaccine.2017.05.057. Epub 2017 Jun 1.


Vitamin D treatment modulates immune activation in cystic fibrosis.

Pincikova T, Paquin-Proulx D, Sandberg JK, Flodström-Tullberg M, Hjelte L.

Clin Exp Immunol. 2017 Sep;189(3):359-371. doi: 10.1111/cei.12984. Epub 2017 May 24.


CFTR is involved in the regulation of glucagon secretion in human and rodent alpha cells.

Edlund A, Pedersen MG, Lindqvist A, Wierup N, Flodström-Tullberg M, Eliasson L.

Sci Rep. 2017 Mar 7;7(1):90. doi: 10.1038/s41598-017-00098-8.


An IFIH1 gene polymorphism associated with risk for autoimmunity regulates canonical antiviral defence pathways in Coxsackievirus infected human pancreatic islets.

Domsgen E, Lind K, Kong L, Hühn MH, Rasool O, van Kuppeveld F, Korsgren O, Lahesmaa R, Flodström-Tullberg M.

Sci Rep. 2016 Dec 21;6:39378. doi: 10.1038/srep39378.


Clinical impact of vitamin D treatment in cystic fibrosis: a pilot randomized, controlled trial.

Pincikova T, Paquin-Proulx D, Sandberg JK, Flodström-Tullberg M, Hjelte L.

Eur J Clin Nutr. 2017 Feb;71(2):203-205. doi: 10.1038/ejcn.2016.259. Epub 2016 Dec 14.


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