Format
Sort by
Items per page

Send to

Choose Destination

Search results

Items: 1 to 20 of 180

1.

Synthesis, biological evaluation and molecular modeling of novel azaspiro dihydrotriazines as influenza virus inhibitors targeting the host factor dihydrofolate reductase (DHFR).

Francesconi V, Giovannini L, Santucci M, Cichero E, Costi MP, Naesens L, Giordanetto F, Tonelli M.

Eur J Med Chem. 2018 Jun 2;155:229-243. doi: 10.1016/j.ejmech.2018.05.059. [Epub ahead of print]

PMID:
29886325
2.

5-(Thiophen-2-yl)-1,3,4-thiadiazole derivatives: synthesis, molecular docking and in vitro cytotoxicity evaluation as potential anticancer agents.

Gomha SM, Edrees MM, Muhammad ZA, El-Reedy AA.

Drug Des Devel Ther. 2018 May 30;12:1511-1523. doi: 10.2147/DDDT.S165276. eCollection 2018.

3.

Identification, Characterization and Molecular Modelling Studies of Schistosoma mansoni Dihydrofolate Reductase Inhibitors: From Assay Development to Hit Identification.

Teles ALB, Silva RR, Ko M, Ferreira GM, Pita SDR, Trossini GHG, Carvalho P, Castilho MS.

Curr Top Med Chem. 2018;18(5):406-417. doi: 10.2174/1568026618666180509150134.

PMID:
29741139
4.

Inhibitors of dihydrofolate reductase as antitumor agents: design, synthesis and biological evaluation of a series of novel nonclassical 6-substituted pyrido[3,2-d]pyrimidines with a three- to five-carbon bridge.

Li H, Fang F, Liu Y, Xue L, Wang M, Guo Y, Wang X, Tian C, Liu J, Zhang Z.

Bioorg Med Chem. 2018 May 15;26(9):2674-2685. doi: 10.1016/j.bmc.2018.04.035. Epub 2018 Apr 19.

PMID:
29691154
5.
6.

Design, synthesis, molecular docking and anti-hepatocellular carcinoma evaluation of novel acyclic pyridine thioglycosides.

Elgemeie GH, Fathy NM, Farag AB, Alkhursani SA.

Nucleosides Nucleotides Nucleic Acids. 2018 Mar 4;37(3):186-198. doi: 10.1080/15257770.2018.1450508. Epub 2018 Apr 2.

PMID:
29608403
7.

Molecular docking to Toxoplasma gondii thymidylate synthase-dihydrofolate reductase and efficacy of raltitrexed in infected mice.

de Paula Reis M, de Lima DA, Pauli KB, Andreotti CEL, de Moraes ALS, Gonçalves DD, Navarro IT, Bueno PSA, Seixas FAV, Gasparotto Junior A, Lourenço ELB.

Parasitol Res. 2018 May;117(5):1465-1471. doi: 10.1007/s00436-018-5835-5. Epub 2018 Mar 17.

PMID:
29550996
8.

1,3,5-triazaspiro[5.5]undeca-2,4-dienes as selective Mycobacterium tuberculosis dihydrofolate reductase inhibitors with potent whole cell activity.

Yang X, Wedajo W, Yamada Y, Dahlroth SL, Neo JJ, Dick T, Chui WK.

Eur J Med Chem. 2018 Jan 20;144:262-276. doi: 10.1016/j.ejmech.2017.12.017. Epub 2017 Dec 7.

PMID:
29274493
9.

Design, synthesis and biological evaluation of antimalarial activity of new derivatives of 2,4,6-s-triazine.

Pathak M, Ojha H, Tiwari AK, Sharma D, Saini M, Kakkar R.

Chem Cent J. 2017 Dec 19;11(1):132. doi: 10.1186/s13065-017-0362-5.

10.

Theoretical Investigation of the Enantioselective Complexations between pfDHFR and Cycloguanil Derivatives.

Kulatee S, Toochinda P, Suksangpanomrung A, Lawtrakul L.

Sci Pharm. 2017 Nov 21;85(4). pii: E37. doi: 10.3390/scipharm85040037.

11.

Discovery of new antimalarial agents: Second-generation dual inhibitors against FP-2 and PfDHFR via fragments assembely.

Chen W, Huang Z, Wang W, Mao F, Guan L, Tang Y, Jiang H, Li J, Huang J, Jiang L, Zhu J.

Bioorg Med Chem. 2017 Dec 15;25(24):6467-6478. doi: 10.1016/j.bmc.2017.10.017. Epub 2017 Oct 16.

PMID:
29111368
12.

In silico analysis of glycinamide ribonucleotide transformylase inhibition by PY873, PY899 and DIA.

Batool S, Nawaz MS, Mushtaq G, Parvaiz F, Kamal MA.

Saudi J Biol Sci. 2017 Sep;24(6):1155-1161. doi: 10.1016/j.sjbs.2014.11.008. Epub 2014 Nov 22.

13.

Linking High-Throughput Screens to Identify MoAs and Novel Inhibitors of Mycobacterium tuberculosis Dihydrofolate Reductase.

Santa Maria JP Jr, Park Y, Yang L, Murgolo N, Altman MD, Zuck P, Adam G, Chamberlin C, Saradjian P, Dandliker P, Boshoff HIM, Barry CE 3rd, Garlisi C, Olsen DB, Young K, Glick M, Nickbarg E, Kutchukian PS.

ACS Chem Biol. 2017 Sep 15;12(9):2448-2456. doi: 10.1021/acschembio.7b00468. Epub 2017 Aug 29.

PMID:
28806050
14.

Benzothiazole analogues: Synthesis, characterization, MO calculations with PM6 and DFT, in silico studies and in vitro antimalarial as DHFR inhibitors and antimicrobial activities.

Thakkar SS, Thakor P, Ray A, Doshi H, Thakkar VR.

Bioorg Med Chem. 2017 Oct 15;25(20):5396-5406. doi: 10.1016/j.bmc.2017.07.057. Epub 2017 Jul 29.

PMID:
28789907
15.

Defining the Structural Basis for Allosteric Product Release from E. coli Dihydrofolate Reductase Using NMR Relaxation Dispersion.

Oyen D, Fenwick RB, Aoto PC, Stanfield RL, Wilson IA, Dyson HJ, Wright PE.

J Am Chem Soc. 2017 Aug 16;139(32):11233-11240. doi: 10.1021/jacs.7b05958. Epub 2017 Aug 3.

PMID:
28737940
16.

1,2,4-Triazole and 1,3,4-oxadiazole analogues: Synthesis, MO studies, in silico molecular docking studies, antimalarial as DHFR inhibitor and antimicrobial activities.

Thakkar SS, Thakor P, Doshi H, Ray A.

Bioorg Med Chem. 2017 Aug 1;25(15):4064-4075. doi: 10.1016/j.bmc.2017.05.054. Epub 2017 May 27.

PMID:
28634040
17.

The role of the Met20 loop in the hydride transfer in Escherichia coli dihydrofolate reductase.

Mhashal AR, Vardi-Kilshtain A, Kohen A, Major DT.

J Biol Chem. 2017 Aug 25;292(34):14229-14239. doi: 10.1074/jbc.M117.777136. Epub 2017 Jun 15.

PMID:
28620051
18.

Pharmacoinformatic Study on the Selective Inhibition of the Protozoan Dihydrofolate Reductase Enzymes.

Sharma VK, Abbat S, Bharatam PV.

Mol Inform. 2017 Nov;36(11). doi: 10.1002/minf.201600156. Epub 2017 Jun 12.

PMID:
28605138
19.

A comparative molecular docking study of curcumin and methotrexate to dihydrofolate reductase.

Hobani Y, Jerah A, Bidwai A.

Bioinformation. 2017 Mar 31;13(3):63-66. doi: 10.6026/97320630013063. eCollection 2017.

20.

An integrated approach towards the discovery of novel non-nucleoside Leishmania major pteridine reductase 1 inhibitors.

Leite FHA, Froes TQ, da Silva SG, de Souza EIM, Vital-Fujii DG, Trossini GHG, Pita SSDR, Castilho MS.

Eur J Med Chem. 2017 May 26;132:322-332. doi: 10.1016/j.ejmech.2017.03.043. Epub 2017 Mar 27.

PMID:
28407565

Supplemental Content

Loading ...
Support Center