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Items: 14

1.

The anti-human cytomegalovirus drug tricin inhibits cyclin-dependent kinase 9.

Sadanari H, Fujimoto KJ, Sugihara Y, Ishida T, Takemoto M, Daikoku T, Murayama T.

FEBS Open Bio. 2018 Feb 20;8(4):646-654. doi: 10.1002/2211-5463.12398. eCollection 2018 Apr.

2.

Tetrahydro-3H-pyrazolo[4,3-a]phenanthridine-based CDK inhibitor.

Opoku-Temeng C, Dayal N, Hernandez DE, Naganna N, Sintim HO.

Chem Commun (Camb). 2018 May 1;54(36):4521-4524. doi: 10.1039/c8cc01154k.

PMID:
29629444
3.

An in silico-designed flavone derivative, 6-fluoro-4'-hydroxy-3',5'-dimetoxyflavone, has a greater anti-human cytomegalovirus effect than ganciclovir in infected cells.

Fujimoto KJ, Nema D, Ninomiya M, Koketsu M, Sadanari H, Takemoto M, Daikoku T, Murayama T.

Antiviral Res. 2018 Jun;154:10-16. doi: 10.1016/j.antiviral.2018.03.006. Epub 2018 Mar 17.

PMID:
29559264
4.

Identification of Atuveciclib (BAY 1143572), the First Highly Selective, Clinical PTEFb/CDK9 Inhibitor for the Treatment of Cancer.

Lücking U, Scholz A, Lienau P, Siemeister G, Kosemund D, Bohlmann R, Briem H, Terebesi I, Meyer K, Prelle K, Denner K, Bömer U, Schäfer M, Eis K, Valencia R, Ince S, von Nussbaum F, Mumberg D, Ziegelbauer K, Klebl B, Choidas A, Nussbaumer P, Baumann M, Schultz-Fademrecht C, Rühter G, Eickhoff J, Brands M.

ChemMedChem. 2017 Nov 8;12(21):1776-1793. doi: 10.1002/cmdc.201700447. Epub 2017 Oct 16.

5.

Identification of novel inhibitors against Cyclin Dependent Kinase 9/Cyclin T1 complex as: Anti cancer agent.

Hussain A, Verma CK, Chouhan U.

Saudi J Biol Sci. 2017 Sep;24(6):1229-1242. doi: 10.1016/j.sjbs.2015.10.003. Epub 2015 Oct 22.

6.

Discovery of a highly potent, selective and novel CDK9 inhibitor as an anticancer drug candidate.

Li Y, Guo Q, Zhang C, Huang Z, Wang T, Wang X, Wang X, Xu G, Liu Y, Yang S, Fan Y, Xiang R.

Bioorg Med Chem Lett. 2017 Aug 1;27(15):3231-3237. doi: 10.1016/j.bmcl.2017.06.041. Epub 2017 Jun 15.

PMID:
28651979
7.

Discovery and SAR of novel pyrazolo[1,5-a]pyrimidines as inhibitors of CDK9.

Phillipson LJ, Segal DH, Nero TL, Parker MW, Wan SS, de Silva M, Guthridge MA, Wei AH, Burns CJ.

Bioorg Med Chem. 2015 Oct 1;23(19):6280-96. doi: 10.1016/j.bmc.2015.08.035. Epub 2015 Aug 28.

PMID:
26349627
8.

Reactivation of latent HIV-1 provirus via targeting protein phosphatase-1.

Tyagi M, Iordanskiy S, Ammosova T, Kumari N, Smith K, Breuer D, Ilatovskiy AV, Kont YS, Ivanov A, Üren A, Kovalskyy D, Petukhov M, Kashanchi F, Nekhai S.

Retrovirology. 2015 Jul 16;12:63. doi: 10.1186/s12977-015-0190-4.

9.

Discovery of novel 5-fluoro-N2,N4-diphenylpyrimidine-2,4-diamines as potent inhibitors against CDK2 and CDK9.

Gao J, Fang C, Xiao Z, Huang L, Chen CH, Wang LT, Lee KH.

Medchemcomm. 2015 Mar 1;6(3):444-454.

10.

Discovery of novel indirubin-3'-monoxime derivatives as potent inhibitors against CDK2 and CDK9.

Yan L, Lai F, Chen X, Xiao Z.

Bioorg Med Chem Lett. 2015 Jun 1;25(11):2447-51. doi: 10.1016/j.bmcl.2015.03.066. Epub 2015 Mar 31.

PMID:
25908517
11.

Computer-aided design, synthesis and validation of 2-phenylquinazolinone fragments as CDK9 inhibitors with anti-HIV-1 Tat-mediated transcription activity.

Sancineto L, Iraci N, Massari S, Attanasio V, Corazza G, Barreca ML, Sabatini S, Manfroni G, Avanzi NR, Cecchetti V, Pannecouque C, Marcello A, Tabarrini O.

ChemMedChem. 2013 Dec;8(12):1941-53. doi: 10.1002/cmdc.201300287. Epub 2013 Oct 21.

PMID:
24150998
12.

Computational study and peptide inhibitors design for the CDK9 - cyclin T1 complex.

Randjelović J, Erić S, Savić V.

J Mol Model. 2013 Apr;19(4):1711-25. doi: 10.1007/s00894-012-1735-2. Epub 2013 Jan 8.

PMID:
23296566
13.

Cross-talk among RNA polymerase II kinases modulates C-terminal domain phosphorylation.

Devaiah BN, Singer DS.

J Biol Chem. 2012 Nov 9;287(46):38755-66. doi: 10.1074/jbc.M112.412015. Epub 2012 Oct 1.

14.

Wogonin and related natural flavones are inhibitors of CDK9 that induce apoptosis in cancer cells by transcriptional suppression of Mcl-1.

Polier G, Ding J, Konkimalla BV, Eick D, Ribeiro N, Köhler R, Giaisi M, Efferth T, Desaubry L, Krammer PH, Li-Weber M.

Cell Death Dis. 2011 Jul 21;2:e182. doi: 10.1038/cddis.2011.66.

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