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Mol Cell. 2005 Nov 23;20(4):493-4.

An essential connection: link between Hsp70's domains at last.

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1
Department of Biochemistry, 433 Babcock Drive, University of Wisconsin, Madison, Madison, Wisconsin 53726, USA.

Abstract

Communication between the ATPase and substrate binding domains of Hsp70 is critical for regulated interaction between this molecular chaperone and its client proteins. In this issue of Molecular Cell, Jiang et al. (2005) report the structure of an intact Hsp70, revealing critical interactions between the two domains.

PMID:
16307911
DOI:
10.1016/j.molcel.2005.11.007
[Indexed for MEDLINE]
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