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Items: 18


Genetic characterization of Polish ccRCC patients: somatic mutation analysis of PBRM1, BAP1 and KDMC5, genomic SNP array analysis in tumor biopsy and preliminary results of chromosome aberrations analysis in plasma cell free DNA.

Kluzek K, Srebniak MI, Majer W, Ida A, Milecki T, Huminska K, van der Helm RM, Silesian A, Wrzesinski TM, Wojciechowicz J, Beverloo BH, Kwias Z, Bluyssen HAR, Wesoly J.

Oncotarget. 2017 Apr 25;8(17):28558-28574. doi: 10.18632/oncotarget.15331.


[No title available]

Bluyssen HA.

Cytokine Growth Factor Rev. 2016 Dec;32:1. doi: 10.1016/j.cytogfr.2016.10.004. Epub 2016 Oct 29. No abstract available.


Targeted inhibition of STATs and IRFs as a potential treatment strategy in cardiovascular disease.

Szelag M, Piaszyk-Borychowska A, Plens-Galaska M, Wesoly J, Bluyssen HA.

Oncotarget. 2016 Jul 26;7(30):48788-48812. doi: 10.18632/oncotarget.9195. Review.


The unique role of STAT2 in constitutive and IFN-induced transcription and antiviral responses.

Blaszczyk K, Nowicka H, Kostyrko K, Antonczyk A, Wesoly J, Bluyssen HA.

Cytokine Growth Factor Rev. 2016 Jun;29:71-81. doi: 10.1016/j.cytogfr.2016.02.010. Epub 2016 Mar 18.


STAT1 and IRF8 in Vascular Inflammation and Cardiovascular Disease: Diagnostic and Therapeutic Potential.

Chmielewski S, Piaszyk-Borychowska A, Wesoly J, Bluyssen HA.

Int Rev Immunol. 2016 Sep 2;35(5):434-454. Epub 2015 Nov 25.


Advances in peptidic and peptidomimetic-based approaches to inhibit STAT signaling in human diseases.

Szelag M, Wesoly J, Bluyssen HA.

Curr Protein Pept Sci. 2016;17(2):135-46. Review.


Expression of pre-selected TMEMs with predicted ER localization as potential classifiers of ccRCC tumors.

Wrzesiński T, Szelag M, Cieślikowski WA, Ida A, Giles R, Zodro E, Szumska J, Poźniak J, Kwias Z, Bluyssen HA, Wesoly J.

BMC Cancer. 2015 Jul 14;15:518. doi: 10.1186/s12885-015-1530-4.


Identification of STAT1 and STAT3 specific inhibitors using comparative virtual screening and docking validation.

Szelag M, Czerwoniec A, Wesoly J, Bluyssen HA.

PLoS One. 2015 Feb 24;10(2):e0116688. doi: 10.1371/journal.pone.0116688. eCollection 2015.


STAT2/IRF9 directs a prolonged ISGF3-like transcriptional response and antiviral activity in the absence of STAT1.

Blaszczyk K, Olejnik A, Nowicka H, Ozgyin L, Chen YL, Chmielewski S, Kostyrko K, Wesoly J, Balint BL, Lee CK, Bluyssen HA.

Biochem J. 2015 Mar 15;466(3):511-24. doi: 10.1042/BJ20140644.


The epigenetic landscape of clear-cell renal cell carcinoma.

Kluzek K, Bluyssen HA, Wesoly J.

J Kidney Cancer VHL. 2015 May 28;2(3):90-104. doi: 10.15586/jkcvhl.2015.33. eCollection 2015.


STAT1-dependent signal integration between IFNγ and TLR4 in vascular cells reflect pro-atherogenic responses in human atherosclerosis.

Chmielewski S, Olejnik A, Sikorski K, Pelisek J, Błaszczyk K, Aoqui C, Nowicka H, Zernecke A, Heemann U, Wesoly J, Baumann M, Bluyssen HA.

PLoS One. 2014 Dec 5;9(12):e113318. doi: 10.1371/journal.pone.0113318. eCollection 2014.


Data mining of atherosclerotic plaque transcriptomes predicts STAT1-dependent inflammatory signal integration in vascular disease.

Sikorski K, Wesoly J, Bluyssen HA.

Int J Mol Sci. 2014 Aug 18;15(8):14313-31. doi: 10.3390/ijms150814313.


Comparative screening and validation as a novel tool to identify STAT-specific inhibitors.

Szeląg M, Czerwoniec A, Wesoly J, Bluyssen HA.

Eur J Pharmacol. 2014 Oct 5;740:417-20. doi: 10.1016/j.ejphar.2014.05.047. Epub 2014 Jun 2.


Molecular properties and medical applications of peptide nucleic acids.

Malcher J, Wesoły J, Bluyssen HA.

Mini Rev Med Chem. 2014 May;14(5):401-10. Review.


In silico simulations of STAT1 and STAT3 inhibitors predict SH2 domain cross-binding specificity.

Szelag M, Sikorski K, Czerwoniec A, Szatkowska K, Wesoly J, Bluyssen HA.

Eur J Pharmacol. 2013 Nov 15;720(1-3):38-48. doi: 10.1016/j.ejphar.2013.10.055. Epub 2013 Nov 6.


Genomics and epigenomics of clear cell renal cell carcinoma: recent developments and potential applications.

Rydzanicz M, Wrzesiński T, Bluyssen HA, Wesoły J.

Cancer Lett. 2013 Dec 1;341(2):111-26. doi: 10.1016/j.canlet.2013.08.006. Epub 2013 Aug 7. Review.


STAT1-mediated signal integration between IFNγ and LPS leads to increased EC and SMC activation and monocyte adhesion.

Sikorski K, Chmielewski S, Przybyl L, Heemann U, Wesoly J, Baumann M, Bluyssen HA.

Am J Physiol Cell Physiol. 2011 Jun;300(6):C1337-44. doi: 10.1152/ajpcell.00276.2010. Epub 2011 Feb 23.


IFN gamma-dependent SOCS3 expression inhibits IL-6-induced STAT3 phosphorylation and differentially affects IL-6 mediated transcriptional responses in endothelial cells.

Bluyssen HA, Rastmanesh MM, Tilburgs C, Jie K, Wesseling S, Goumans MJ, Boer P, Joles JA, Braam B.

Am J Physiol Cell Physiol. 2010 Aug;299(2):C354-62. doi: 10.1152/ajpcell.00513.2009. Epub 2010 May 19.

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