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Items: 1 to 20 of 1385

1.

Small Molecule Antagonists of the Nuclear Androgen Receptor for the Treatment of Castration-Resistant Prostate Cancer.

Johnson JK, Skoda EM, Zhou J, Parrinello E, Wang D, O'Malley K, Eyer BR, Kazancioglu M, Eisermann K, Johnston PA, Nelson JB, Wang Z, Wipf P.

ACS Med Chem Lett. 2016 May 27;7(8):785-90. doi: 10.1021/acsmedchemlett.6b00186.

2.

Phenotypic Assessment and the Discovery of Topiramate.

Maryanoff BE.

ACS Med Chem Lett. 2016 Jun 13;7(7):662-5. doi: 10.1021/acsmedchemlett.6b00176.

3.

Correction to "Design and Synthesis of a Mitochondria-Targeted Mimic of Glutathione Peroxidase, MitoEbselen-2, as a Radiation Mitigator".

Stoyanovsky DA, Jiang J, Murphy MP, Epperly M, Zhang X, Li S, Greenberger J, Kagan V, Bayır H.

ACS Med Chem Lett. 2016 Jun 1;7(6):653-4. doi: 10.1021/acsmedchemlett.6b00212.

4.

Correction for "Synthesis of Mixed Opioid Affinity Cyclic Endomorphin-2 Analogues with Fluorinated Phenylalanines".

Piekielna J, Perlikowska R, do-Rego JC, do-Rego JL, Cerlesi MC, Calo G, Kluczyk A, Łapiński K, Tömböly C, Janecka A.

ACS Med Chem Lett. 2016 May 9;7(6):652. doi: 10.1021/acsmedchemlett.6b00162.

5.

2,8-Disubstituted-1,6-Naphthyridines and 4,6-Disubstituted-Isoquinolines with Potent, Selective Affinity for CDK8/19.

Mallinger A, Schiemann K, Rink C, Sejberg J, Honey MA, Czodrowski P, Stubbs M, Poeschke O, Busch M, Schneider R, Schwarz D, Musil D, Burke R, Urbahns K, Workman P, Wienke D, Clarke PA, Raynaud FI, Eccles SA, Esdar C, Rohdich F, Blagg J.

ACS Med Chem Lett. 2016 Mar 28;7(6):573-8. doi: 10.1021/acsmedchemlett.6b00022.

6.

Pyrrolidinones as Modulators of Neurogenesis.

Rosse G.

ACS Med Chem Lett. 2016 Jan 4;7(1):15-6. doi: 10.1021/acsmedchemlett.5b00493. No abstract available.

7.

Anti-Staphylococcal Biofilm Effects of Human Cathelicidin Peptides.

Mishra B, Golla RM, Lau K, Lushnikova T, Wang G.

ACS Med Chem Lett. 2015 Dec 4;7(1):117-21. doi: 10.1021/acsmedchemlett.5b00433.

8.

Discovery of MK-8831, A Novel Spiro-Proline Macrocycle as a Pan-Genotypic HCV-NS3/4a Protease Inhibitor.

Neelamkavil SF, Agrawal S, Bara T, Bennett C, Bhat S, Biswas D, Brockunier L, Buist N, Burnette D, Cartwright M, Chackalamannil S, Chase R, Chelliah M, Chen A, Clasby M, Colandrea VJ, Davies IW, Eagen K, Guo Z, Han Y, Howe J, Jayne C, Josien H, Kargman S, Marcantonio K, Miao S, Miller R, Nolting A, Pinto P, Rajagopalan M, Ruck RT, Shah U, Soriano A, Sperbeck D, Velazquez F, Wu J, Xia Y, Venkatraman S.

ACS Med Chem Lett. 2015 Dec 22;7(1):111-6. doi: 10.1021/acsmedchemlett.5b00425.

9.

Potent Small Agonists of Protease Activated Receptor 2.

Yau MK, Suen JY, Xu W, Lim J, Liu L, Adams MN, He Y, Hooper JD, Reid RC, Fairlie DP.

ACS Med Chem Lett. 2015 Nov 30;7(1):105-10. doi: 10.1021/acsmedchemlett.5b00429.

10.

Pyridones as Highly Selective, Noncovalent Inhibitors of T790M Double Mutants of EGFR.

Bryan MC, Burdick DJ, Chan BK, Chen Y, Clausen S, Dotson J, Eigenbrot C, Elliott R, Hanan EJ, Heald R, Jackson P, La H, Lainchbury M, Malek S, Mann SE, Purkey HE, Schaefer G, Schmidt S, Seward E, Sideris S, Wang S, Yen I, Yu C, Heffron TP.

ACS Med Chem Lett. 2015 Dec 17;7(1):100-4. doi: 10.1021/acsmedchemlett.5b00428.

11.

Tetrahydroisoquinoline Phenols: Selective Estrogen Receptor Downregulator Antagonists with Oral Bioavailability in Rat.

Scott JS, Bailey A, Davies RD, Degorce SL, MacFaul PA, Gingell H, Moss T, Norman RA, Pink JH, Rabow AA, Roberts B, Smith PD.

ACS Med Chem Lett. 2015 Dec 19;7(1):94-9. doi: 10.1021/acsmedchemlett.5b00413.

12.

Probabilistic Approach to Generating MPOs and Its Application as a Scoring Function for CNS Drugs.

Gunaydin H.

ACS Med Chem Lett. 2015 Dec 2;7(1):89-93. doi: 10.1021/acsmedchemlett.5b00390.

13.

Optimizing Ligand Efficiency of Selective Androgen Receptor Modulators (SARMs).

Handlon AL, Schaller LT, Leesnitzer LM, Merrihew RV, Poole C, Ulrich JC, Wilson JW, Cadilla R, Turnbull P.

ACS Med Chem Lett. 2015 Nov 19;7(1):83-8. doi: 10.1021/acsmedchemlett.5b00377.

14.

Synthesis and Evaluation of Oxyguanidine Analogues of the Cysteine Protease Inhibitor WRR-483 against Cruzain.

Jones BD, Tochowicz A, Tang Y, Cameron MD, McCall LI, Hirata K, Siqueira-Neto JL, Reed SL, McKerrow JH, Roush WR.

ACS Med Chem Lett. 2015 Dec 15;7(1):77-82. doi: 10.1021/acsmedchemlett.5b00336.

15.

Potent, Selective, and Orally Bioavailable Inhibitors of VPS34 Provide Chemical Tools to Modulate Autophagy in Vivo.

Honda A, Harrington E, Cornella-Taracido I, Furet P, Knapp MS, Glick M, Triantafellow E, Dowdle WE, Wiedershain D, Maniara W, Moore C, Finan PM, Hamann LG, Firestone B, Murphy LO, Keaney EP.

ACS Med Chem Lett. 2015 Nov 13;7(1):72-6. doi: 10.1021/acsmedchemlett.5b00335.

16.

Development of Noviomimetics as C-Terminal Hsp90 Inhibitors.

Anyika M, McMullen M, Forsberg LK, Dobrowsky RT, Blagg BS.

ACS Med Chem Lett. 2015 Dec 9;7(1):67-71. doi: 10.1021/acsmedchemlett.5b00331.

17.

A New Highly Reactive and Low Lipophilicity Fluorine-18 Labeled Tetrazine Derivative for Pretargeted PET Imaging.

Keinänen O, Li XG, Chenna NK, Lumen D, Ott J, Molthoff CF, Sarparanta M, Helariutta K, Vuorinen T, Windhorst AD, Airaksinen AJ.

ACS Med Chem Lett. 2015 Dec 10;7(1):62-6. doi: 10.1021/acsmedchemlett.5b00330.

18.

Monoamine Oxidase Inhibitory Activity of Novel Pyrazoline Analogues: Curcumin Based Design and Synthesis.

Badavath VN, Baysal İ, Ucar G, Sinha BN, Jayaprakash V.

ACS Med Chem Lett. 2015 Dec 1;7(1):56-61. doi: 10.1021/acsmedchemlett.5b00326.

19.

Discovery of a Potent and Orally Efficacious TGR5 Receptor Agonist.

Agarwal S, Patil A, Aware U, Deshmukh P, Darji B, Sasane S, Sairam KV, Priyadarsiny P, Giri P, Patel H, Giri S, Jain M, Desai RC.

ACS Med Chem Lett. 2015 Nov 20;7(1):51-5. doi: 10.1021/acsmedchemlett.5b00323.

20.

iPSC Neuronal Assay Identifies Amaryllidaceae Pharmacophore with Multiple Effects against Herpesvirus Infections.

McNulty J, D'Aiuto L, Zhi Y, McClain L, Zepeda-Velázquez C, Ler S, Jenkins HA, Yee MB, Piazza P, Yolken RH, Kinchington PR, Nimgaonkar VL.

ACS Med Chem Lett. 2015 Nov 19;7(1):46-50. doi: 10.1021/acsmedchemlett.5b00318.

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