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Items: 1 to 20 of 1850

1.

Nicotinamide Phosphoribosyltransferase Inhibitor as a Novel Payload for Antibody-Drug Conjugates.

Karpov AS, Abrams T, Clark S, Raikar A, D'Alessio JA, Dillon MP, Gesner TG, Jones D, Lacaud M, Mallet W, Martyniuk P, Meredith E, Mohseni M, Nieto-Oberhuber CM, Palacios D, Perruccio F, Piizzi G, Zurini M, Bialucha CU.

ACS Med Chem Lett. 2018 Jun 28;9(8):838-842. doi: 10.1021/acsmedchemlett.8b00254. eCollection 2018 Aug 9.

2.

Target-Directed Self-Assembly of Homodimeric Drugs Against β-Tryptase.

Giardina SF, Werner DS, Pingle M, Foreman KW, Bergstrom DE, Arnold LD, Barany F.

ACS Med Chem Lett. 2018 Jul 5;9(8):827-831. doi: 10.1021/acsmedchemlett.8b00204. eCollection 2018 Aug 9.

3.

Investigating the Behavior of Published PAINS Alerts Using a Pharmaceutical Company Data Set.

Vidler LR, Watson IA, Margolis BJ, Cummins DJ, Brunavs M.

ACS Med Chem Lett. 2018 Jul 10;9(8):792-796. doi: 10.1021/acsmedchemlett.8b00097. eCollection 2018 Aug 9.

4.

Selective Irreversible Inhibitors of the Wnt-Deacylating Enzyme NOTUM Developed by Activity-Based Protein Profiling.

Suciu RM, Cognetta AB 3rd, Potter ZE, Cravatt BF.

ACS Med Chem Lett. 2018 May 26;9(6):563-568. doi: 10.1021/acsmedchemlett.8b00191. eCollection 2018 Jun 14.

5.

Homogeneous Assay for Target Engagement Utilizing Bioluminescent Thermal Shift.

Dart ML, Machleidt T, Jost E, Schwinn MK, Robers MB, Shi C, Kirkland TA, Killoran MP, Wilkinson JM, Hartnett JR, Zimmerman K, Wood KV.

ACS Med Chem Lett. 2018 Apr 16;9(6):546-551. doi: 10.1021/acsmedchemlett.8b00081. eCollection 2018 Jun 14.

6.

Expansion of cat-ELCCA for the Discovery of Small Molecule Inhibitors of the Pre-let-7-Lin28 RNA-Protein Interaction.

Lorenz DA, Kaur T, Kerk SA, Gallagher EE, Sandoval J, Garner AL.

ACS Med Chem Lett. 2018 May 16;9(6):517-521. doi: 10.1021/acsmedchemlett.8b00126. eCollection 2018 Jun 14.

7.

Correction to "Design, Synthesis, and Antibacterial Evaluation of Oxazolidinones with Fused Heterocyclic C-Ring Substructure".

Deshmukh MS, Jain N.

ACS Med Chem Lett. 2018 Apr 19;9(5):512. doi: 10.1021/acsmedchemlett.8b00164. eCollection 2018 May 10.

8.

Efficient Syntheses of Cocaine Vaccines and Their in Vivo Evaluation.

Kimishima A, Olson ME, Natori Y, Janda KD.

ACS Med Chem Lett. 2018 Apr 16;9(5):411-416. doi: 10.1021/acsmedchemlett.8b00051. eCollection 2018 May 10.

9.

Correction to "The Discovery of 3,3'-Spiro[azetidine]-2-oxo-indoline Derivatives as Fusion Inhibitors for Treatment of RSV Infection".

Shi W, Jiang Z, He H, Xiao F, Lin F, Sun Y, Hou L, Shen L, Han L, Zeng M, Lai K, Gu Z, Chen X, Zhao T, Guo L, Yang C, Li J, Chen S.

ACS Med Chem Lett. 2018 Mar 30;9(4):397. doi: 10.1021/acsmedchemlett.8b00139. eCollection 2018 Apr 12.

10.

Discovery of Tirasemtiv, the First Direct Fast Skeletal Muscle Troponin Activator.

Collibee SE, Bergnes G, Muci A, Browne WF 4th, Garard M, Hinken AC, Russell AJ, Suehiro I, Hartman J, Kawas R, Lu PP, Lee KH, Marquez D, Tomlinson M, Xu D, Kennedy A, Hwee D, Schaletzky J, Leung K, Malik FI, Morgans DJ Jr, Morgan BP.

ACS Med Chem Lett. 2018 Feb 13;9(4):354-358. doi: 10.1021/acsmedchemlett.7b00546. eCollection 2018 Apr 12.

11.

Discovery of AG-120 (Ivosidenib): A First-in-Class Mutant IDH1 Inhibitor for the Treatment of IDH1 Mutant Cancers.

Popovici-Muller J, Lemieux RM, Artin E, Saunders JO, Salituro FG, Travins J, Cianchetta G, Cai Z, Zhou D, Cui D, Chen P, Straley K, Tobin E, Wang F, David MD, Penard-Lacronique V, Quivoron C, Saada V, de Botton S, Gross S, Dang L, Yang H, Utley L, Chen Y, Kim H, Jin S, Gu Z, Yao G, Luo Z, Lv X, Fang C, Yan L, Olaharski A, Silverman L, Biller S, Su SM, Yen K.

ACS Med Chem Lett. 2018 Jan 19;9(4):300-305. doi: 10.1021/acsmedchemlett.7b00421. eCollection 2018 Apr 12.

12.

Indolylmaleimide Derivative IM-17 Shows Cardioprotective Effects in Ischemia-Reperfusion Injury.

Dodo K, Shimizu T, Sasamori J, Aihara K, Terayama N, Nakao S, Iuchi K, Takahashi M, Sodeoka M.

ACS Med Chem Lett. 2018 Jan 29;9(3):182-187. doi: 10.1021/acsmedchemlett.7b00454. eCollection 2018 Mar 8.

13.

Late-Stage Microsomal Oxidation Reduces Drug-Drug Interaction and Identifies Phosphodiesterase 2A Inhibitor PF-06815189.

Stepan AF, Tran TP, Helal CJ, Brown MS, Chang C, O'Connor RE, De Vivo M, Doran SD, Fisher EL, Jenkinson S, Karanian D, Kormos BL, Sharma R, Walker GS, Wright AS, Yang EX, Brodney MA, Wager TT, Verhoest PR, Obach RS.

ACS Med Chem Lett. 2018 Jan 4;9(2):68-72. doi: 10.1021/acsmedchemlett.7b00343. eCollection 2018 Feb 8.

14.

Structure-Activity Relationship Studies with Tetrahydroquinoline Analogs as EPAC Inhibitors.

Sonawane YA, Zhu Y, Garrison JC, Ezell EL, Zahid M, Cheng X, Natarajan A.

ACS Med Chem Lett. 2017 Oct 2;8(11):1183-1187. doi: 10.1021/acsmedchemlett.7b00358. eCollection 2017 Nov 9.

15.

Discovery of Spiro Oxazolidinediones as Selective, Orally Bioavailable Inhibitors of p300/CBP Histone Acetyltransferases.

Michaelides MR, Kluge A, Patane M, Van Drie JH, Wang C, Hansen TM, Risi RM, Mantei R, Hertel C, Karukurichi K, Nesterov A, McElligott D, de Vries P, Langston JW, Cole PA, Marmorstein R, Liu H, Lasko L, Bromberg KD, Lai A, Kesicki EA.

ACS Med Chem Lett. 2017 Dec 13;9(1):28-33. doi: 10.1021/acsmedchemlett.7b00395. eCollection 2018 Jan 11.

16.

Correction to "Apratoxin S10, a Dual Inhibitor of Angiogenesis and Cancer Cell Growth To Treat Highly Vascularized Tumors".

Cai W, Chen QY, Dang LH, Luesch H.

ACS Med Chem Lett. 2017 Dec 7;8(12):1342. doi: 10.1021/acsmedchemlett.7b00498. eCollection 2017 Dec 14.

17.

Correction to "Structure-Based Design of ASK1 Inhibitors as Potential Agents for Heart Failure".

Lanier M, Pickens J, Bigi SV, Bradshaw-Pierce EL, Chambers A, Cheruvallath ZS, Cole D, Dougan DR, Ermolieff J, Gibson T, Halkowycz P, Hirokawa A, Ivetac A, McBride C, Miura J, Nunez E, Sabat M, Tyhonas J, Wang H, Wang X, Swann S.

ACS Med Chem Lett. 2017 Nov 8;8(12):1341. doi: 10.1021/acsmedchemlett.7b00457. eCollection 2017 Dec 14.

18.

Long-Lasting and Fast-Acting in Vivo Efficacious Antiplasmodial Azepanylcarbazole Amino Alcohol.

Abla N, Bashyam S, Charman SA, Greco B, Hewitt P, Jiménez-Díaz MB, Katneni K, Kubas H, Picard D, Sambandan Y, Sanz L, Smith D, Wang T, Willis P, Wittlin S, Spangenberg T.

ACS Med Chem Lett. 2017 Nov 28;8(12):1304-1308. doi: 10.1021/acsmedchemlett.7b00391. eCollection 2017 Dec 14.

19.

Antitubercular Nitroimidazoles Revisited: Synthesis and Activity of the Authentic 3-Nitro Isomer of Pretomanid.

Thompson AM, Bonnet M, Lee HH, Franzblau SG, Wan B, Wong GS, Cooper CB, Denny WA.

ACS Med Chem Lett. 2017 Nov 13;8(12):1275-1280. doi: 10.1021/acsmedchemlett.7b00356. eCollection 2017 Dec 14.

20.

Novel Polyamine-Naphthalene Diimide Conjugates Targeting Histone Deacetylases and DNA for Cancer Phenotype Reprogramming.

Pasini A, Marchetti C, Sissi C, Cortesi M, Giordano E, Minarini A, Milelli A.

ACS Med Chem Lett. 2017 Oct 24;8(12):1218-1223. doi: 10.1021/acsmedchemlett.7b00289. eCollection 2017 Dec 14.

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