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Stereospecific gas chromatographic/mass spectrometric assay of the chiral labetalol metabolite 3-amino-1-phenylbutane.
Changchit A, Gal J, Zirrolli JA. Changchit A, et al. Biol Mass Spectrom. 1991 Dec;20(12):751-8. doi: 10.1002/bms.1200201202. Biol Mass Spectrom. 1991. PMID: 1812984
We previously identified 3-amino-1-phenylbutane (APB) as an oxidative N-dealkylated, metabolite of the antihypertensive agent labetalol. ...
We previously identified 3-amino-1-phenylbutane (APB) as an oxidative N-dealkylated, metabolite of the antihyper …
Disposition, metabolism, and pharmacodynamics of labetalol in adult sheep.
Yeleswaram K, Rurak DW, Kwan E, Hall C, Doroudian A, Abbott FS, Axelson JE. Yeleswaram K, et al. Drug Metab Dispos. 1993 Mar-Apr;21(2):284-92. Drug Metab Dispos. 1993. PMID: 8097698
The cumulative urinary excretion of labetalol as unchanged drug, glucuronide and sulfate was found to be 1.61 +/- 0.3, 11.46 +/- 2.83, and 1.47 +/- 0.74% of the dose, respectively. Using GC-mass selective detection, the presence of 3-amino-1-phenylbutane …
The cumulative urinary excretion of labetalol as unchanged drug, glucuronide and sulfate was found to be 1.61 +/- 0.3, 11.46 +/- 2.83, and 1 …
Labetalol is metabolized oxidatively in humans.
Gal J, Zirrolli JA, Lichtenstein PS. Gal J, et al. Res Commun Chem Pathol Pharmacol. 1988 Oct;62(1):3-17. Res Commun Chem Pathol Pharmacol. 1988. PMID: 3205978
In this study, urine samples obtained from three patients on chronic labetalol therapy for hypertension were analyzed initially by thin layer chromatography for the presence of other metabolites. All three urine samples were found to contain 3-amino-1-phen …
In this study, urine samples obtained from three patients on chronic labetalol therapy for hypertension were analyzed initially by thin laye …
Immobilization of Escherichia coli containing ω-transaminase activity in LentiKats®.
Cárdenas-Fernández M, Neto W, López C, Álvaro G, Tufvesson P, Woodley JM. Cárdenas-Fernández M, et al. Biotechnol Prog. 2012 May-Jun;28(3):693-8. doi: 10.1002/btpr.1538. Epub 2012 May 21. Biotechnol Prog. 2012. PMID: 22467646
Whole Escherichia coli cells overexpressing omega-transaminase (omega-TA) and immobilized cells entrapped in LentiKats were used as biocatalysts in the asymmetric synthesis of the aromatic chiral amines 1-phenylethylamine (PEA) and 3-amino-1-phenylbutane …
Whole Escherichia coli cells overexpressing omega-transaminase (omega-TA) and immobilized cells entrapped in LentiKats were used as biocatal …
Studies on the photostability and in vitro phototoxicity of Labetalol.
Andrisano V, Ballardini R, Hrelia P, Cameli N, Tosti A, Gotti R, Cavrini V. Andrisano V, et al. Eur J Pharm Sci. 2001 Feb;12(4):495-504. doi: 10.1016/s0928-0987(00)00218-9. Eur J Pharm Sci. 2001. PMID: 11231117
The main photodegradation products were isolated and characterized by NMR and mass spectrometry; labetalol was found to give 3-amino-1-phenylbutane and salicylamide-4-carboxaldehyde as the main photoproducts. ...
The main photodegradation products were isolated and characterized by NMR and mass spectrometry; labetalol was found to give 3-ami …
Enantiospecific drug analysis via the ortho-phthalaldehyde/homochiral thiol derivatization method.
Desai DM, Gal J. Desai DM, et al. J Chromatogr. 1993 Jan 22;629(2):215-28. doi: 10.1016/0021-9673(93)87035-k. J Chromatogr. 1993. PMID: 8429083
We have therefore examined the applicability of the method to the chiral resolution of several pharmaceutical amines. o-Phthaldialdehyde and four commercially available homochiral thiols were used to study the separation of the enantiomers of amphetamine, p-hydroxyamphetamine, p- …
We have therefore examined the applicability of the method to the chiral resolution of several pharmaceutical amines. o-Phthaldialdehyde and …
Analysis of amphetamine and congeners in illicit samples by liquid chromatography and capillary electrophoresis.
Di Pietra AM, Gotti R, Del Borrello E, Pomponio R, Cavrini V. Di Pietra AM, et al. J Anal Toxicol. 2001 Mar;25(2):99-105. doi: 10.1093/jat/25.2.99. J Anal Toxicol. 2001. PMID: 11300514
Screening methods based on liquid chromatography (HPLC) and capillary electrophoresis (CE) have been developed for the identification and determination of amphetamine, methamphetamine, 3,4-methylenedioxyamphetamine, 3,4-methylenedioxymethamphetamine, and 3,4-methylenedioxyethylam …
Screening methods based on liquid chromatography (HPLC) and capillary electrophoresis (CE) have been developed for the identification and de …
A labetalol metabolite with analytical characteristics resembling amphetamines.
Gilbert RB, Peng PI, Wong D. Gilbert RB, et al. J Anal Toxicol. 1995 Mar-Apr;19(2):84-6. doi: 10.1093/jat/19.2.84. J Anal Toxicol. 1995. PMID: 7769792
A metabolite of labetalol that is responsible for previous reports of false-positive assays for amphetamines by thin-layer chromatography and immunoassay has been identified. The compound, 3-amino-1-phenylbutane (APB), an oxidative metabolite of labeta …
A metabolite of labetalol that is responsible for previous reports of false-positive assays for amphetamines by thin-layer chromatography an …