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Year Number of Results
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228 results

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Quoted phrases not found in phrase index: "1,3-dimethyl propanedioate", "dimethyl propanedioate"
Page 1
Succinate Dehydrogenase Supports Metabolic Repurposing of Mitochondria to Drive Inflammatory Macrophages.
Mills EL, Kelly B, Logan A, Costa ASH, Varma M, Bryant CE, Tourlomousis P, Däbritz JHM, Gottlieb E, Latorre I, Corr SC, McManus G, Ryan D, Jacobs HT, Szibor M, Xavier RJ, Braun T, Frezza C, Murphy MP, O'Neill LA. Mills EL, et al. Cell. 2016 Oct 6;167(2):457-470.e13. doi: 10.1016/j.cell.2016.08.064. Epub 2016 Sep 22. Cell. 2016. PMID: 27667687 Free PMC article.
RNA sequencing reveals that this combination induces a pro-inflammatory gene expression profile, while an inhibitor of succinate oxidation, dimethyl malonate (DMM), promotes an anti-inflammatory outcome. Blocking ROS production with rotenone by uncoupling mitochondr …
RNA sequencing reveals that this combination induces a pro-inflammatory gene expression profile, while an inhibitor of succinate oxidation, …
Bmal1 integrates mitochondrial metabolism and macrophage activation.
Alexander RK, Liou YH, Knudsen NH, Starost KA, Xu C, Hyde AL, Liu S, Jacobi D, Liao NS, Lee CH. Alexander RK, et al. Elife. 2020 May 12;9:e54090. doi: 10.7554/eLife.54090. Elife. 2020. PMID: 32396064 Free PMC article.
Consequently, M-BKO increases melanoma tumor burden, whereas administering the SDH inhibitor dimethyl malonate suppresses tumor growth. Therefore, Bmal1 functions as a metabolic checkpoint that integrates macrophage mitochondrial metabolism, redox homeostasis and ef …
Consequently, M-BKO increases melanoma tumor burden, whereas administering the SDH inhibitor dimethyl malonate suppresses tumo …
Metabolic reprogramming in inflammatory microglia indicates a potential way of targeting inflammation in Alzheimer's disease.
Sangineto M, Ciarnelli M, Cassano T, Radesco A, Moola A, Bukke VN, Romano A, Villani R, Kanwal H, Capitanio N, Duda L, Avolio C, Serviddio G. Sangineto M, et al. Redox Biol. 2023 Oct;66:102846. doi: 10.1016/j.redox.2023.102846. Epub 2023 Aug 9. Redox Biol. 2023. PMID: 37586250 Free PMC article.
We showed that by inhibiting succinate dehydrogenase (SDH) with dimethyl malonate (DMM), it is possible to modulate the LPS-induced metabolic rewiring, facilitating an anti-inflammatory phenotype. ...
We showed that by inhibiting succinate dehydrogenase (SDH) with dimethyl malonate (DMM), it is possible to modulate the LPS-in …
Synthesis of Ester-Substituted Indolizines from 2-Propargyloxypyridines and 1,3-Dicarbonyls.
Anderson CE, Bos HI, Dreher DM, Hartgerink CT, Scholtens CJ, Staples RJ. Anderson CE, et al. J Org Chem. 2022 Aug 5;87(15):10241-10249. doi: 10.1021/acs.joc.2c01219. Epub 2022 Jul 18. J Org Chem. 2022. PMID: 35849640
Two new complementary Au(I)-catalyzed methods for the preparation of ester-substituted indolizines from easily accessible 2-propargyloxypyridines and either acetoacetates or dimethyl malonate are reported. These reactions tolerate a wide range of functionality, allo …
Two new complementary Au(I)-catalyzed methods for the preparation of ester-substituted indolizines from easily accessible 2-propargyloxypyri …
Synthesis of 2-(3-(3,5-bis(trifluoromethyl)phenyl)thioureido)-3-((dimethylamino)methyl)camphor organocatalysts.
Grošelj U, Ričko S, Svete J, Stanovnik B. Grošelj U, et al. Chirality. 2012 May;24(5):412-9. doi: 10.1002/chir.22035. Epub 2012 Apr 19. Chirality. 2012. PMID: 22514057
Novel organocatalysts 7-9, 19/19' have been evaluated in a model reaction of Michael addition of dimethyl malonate to trans-beta-nitrostyrene with low to moderate enantioselectivities (20%-60% ee). ...
Novel organocatalysts 7-9, 19/19' have been evaluated in a model reaction of Michael addition of dimethyl malonate to trans-be …
Four Routes to 3-(3-Methoxy-1,3-dioxopropyl)pyrrole, a Core Motif of Rings C and E in Photosynthetic Tetrapyrroles.
Chau Nguyen K, Nguyen Tran AT, Wang P, Zhang S, Wu Z, Taniguchi M, Lindsey JS. Chau Nguyen K, et al. Molecules. 2023 Jan 30;28(3):1323. doi: 10.3390/molecules28031323. Molecules. 2023. PMID: 36770988 Free PMC article.
Routes 1-3 entail a Pd-mediated coupling process of a 3-iodopyrrole with potassium methyl malonate, whereas route 4 relies on electrophilic substitution of TIPS-pyrrole with methyl malonyl chloride. ...
Routes 1-3 entail a Pd-mediated coupling process of a 3-iodopyrrole with potassium methyl malonate, whereas route 4 relies on …
Dimethyl malonate preserves renal and mitochondrial functions following ischemia-reperfusion via inhibition of succinate dehydrogenase.
Carlström M, Rannier Ribeiro Antonino Carvalho L, Guimaraes D, Boeder A, Schiffer TA. Carlström M, et al. Redox Biol. 2024 Feb;69:102984. doi: 10.1016/j.redox.2023.102984. Epub 2023 Dec 5. Redox Biol. 2024. PMID: 38061207 Free PMC article.
AIM: To investigate the therapeutic potential of succinate dehydrogenase inhibition, by using dimethyl malonate (DMM), on kidney and mitochondria functions in a mouse model of AKI. ...
AIM: To investigate the therapeutic potential of succinate dehydrogenase inhibition, by using dimethyl malonate (DMM), on kidn …
Asymmetric Total Synthesis of (+)-Alstonlarsine A.
Yao JJ, Ding R, Chen X, Zhai H. Yao JJ, et al. J Am Chem Soc. 2022 Aug 10;144(31):14396-14402. doi: 10.1021/jacs.2c06518. Epub 2022 Jul 27. J Am Chem Soc. 2022. PMID: 35894835
The prominent features of the current synthesis include the following: (i) a Pd/self-adaptable ligand complex-catalyzed asymmetric allylic alkylation of 2-methyl-2-cyclopentenyl carbonate with 2-indolylsubstituted dimethyl malonate to establish the key stereocenter …
The prominent features of the current synthesis include the following: (i) a Pd/self-adaptable ligand complex-catalyzed asymmetric allylic a …
228 results